Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway

Morimatsu, Maho; Yamashita, Erika; Seno, Shigeto et al.

Inflammation and Regeneration, 2020, 40(1), 15

Number of Access:1,701（2025-09-29 10:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93169

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Title
Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
Creator
CreatorName
Morimatsu, Maho
NRID
1000010880106 1000010880106
ORCID
0000-0002-3973-9529 0000-0002-3973-9529
researchmap permalink
erika-ys erika-ys
CreatorName
Yamashita, Erika
NRID
1000030432462 1000030432462
ORCID
0000-0003-3861-6444 0000-0003-3861-6444
researchmap permalink
ssenoo ssenoo
Scopus Author ID
57214748425 57214748425
CreatorName
Seno, Shigeto
NRID
1000080631184 1000080631184
researchmap permalink
kik kik
Scopus Author ID
36497716100 36497716100
CreatorName
Sudo, Takao
NRID
1000060710069 1000060710069
researchmap permalink
jkikuta jkikuta
Scopus Author ID
36637603800 36637603800
CreatorName
Kikuta, Junichi
NRID
1000090707655 1000090707655
CreatorName
Mizuno, Hiroki
NRID
1000000346131 1000000346131
ORCID
0000-0002-4552-783X 0000-0002-4552-783X
researchmap permalink
read0092307 read0092307
Scopus Author ID
6506703054 6506703054
CreatorName
Okuzaki, Daisuke
NRID
1000010636830 1000010636830
researchmap permalink
daisukem daisukem
Scopus Author ID
35315737900 35315737900
CreatorName
Motooka, Daisuke
NRID
1000010324758 1000010324758
researchmap permalink
read0076684 read0076684
Scopus Author ID
35074093500 35074093500
CreatorName
Ishii, Masaru
Subject
Bone marrow
Cancer therapy
Cell migration
Cell motility
Chemoresistance
In vivo imaging
Leukemia
Microscopic imaging
Serum response factor (SRF)
Description
Morimatsu M., Yamashita E., Seno S., et al. Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway. Inflammation and Regeneration 40, 15 (2020); https://doi.org/10.1186/s41232-020-00127-6.
Abstract
Background: Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear. Methods: Using intravital bone imaging, we characterized the behavior of murine acute myeloid leukemia (AML) cells (C1498) in the bone marrow before and after chemotherapy with cytarabine. Results: Proliferative C1498 cells exhibited high motility in the bone marrow. Cytarabine treatment impaired the motility of residual C1498 cells. However, C1498 cells regained their migration potential after relapse. RNA sequencing revealed that cytarabine treatment promoted MRTF-SRF pathway activation. MRTF inhibition using CCG-203971 augmented the anti-tumor effects of chemotherapy in our AML mouse model, as well as suppressed the migration of chemoresistant C1498 cells. Conclusions: These results provide novel insight into the role of cell migration arrest on the development of chemoresistance in AML, as well as provide a strong rationale for the modulation of cellular motility as a therapeutic target for refractory AML.
Publisher
BioMed Central
Source Title
Inflammation and Regeneration
Volume (Issue)
40(1)
Page
15
Date of Issued
2020-12-01
Language
English
Handle URL
https://hdl.handle.net/11094/93169
eISSN
18808190
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1186/s41232-020-00127-6
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article