Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population

Tomofuji, Yoshihiko; Kishikawa, Toshihiro; Sonehara, Kyuto; Maeda, Yuichi; Ogawa, Kotaro; Kawabata, Shuhei; Oguro-Igashira, Eri; Okuno, Tatsusada; Nii, Takuro; Kinoshita, Makoto; Takagaki, Masatoshi; Yamamoto, Kenichi; Arase, Noriko; Yagita-Sakamaki, Mayu; Hosokawa, Akiko; Motooka, Daisuke; Matsumoto, Yuki; Matsuoka, Hidetoshi; Yoshimura, Maiko; Ohshima, Shiro; Nakamura, Shota; Fujimoto, Manabu; Inohara, Hidenori; Kishima, Haruhiko; Mochizuki, Hideki; Takeda, Kiyoshi; Kumanogoh, Atsushi; Okada, Yukinori

doi:https://doi.org/10.1016/j.celrep.2023.113324

Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population

Tomofuji, Yoshihiko; Kishikawa, Toshihiro; Sonehara, Kyuto et al.

Cell Reports, 2023, 42(11), 113324

Number of Access:4,552（2025-07-18 20:01 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93234

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Title	Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population
Creator	CreatorName Tomofuji, Yoshihiko
	NRID 1000020756944 1000020756944 researchmap permalink tk0513 tk0513 CreatorName Kishikawa, Toshihiro
	NRID 1000060975358 1000060975358 CreatorName Sonehara, Kyuto
	NRID 1000010815658 1000010815658 CreatorName Maeda, Yuichi
	NRID 1000080870500 1000080870500 researchmap permalink jihdiegisojosugudc jihdiegisojosugudc Scopus Author ID 57200553653 57200553653 CreatorName Ogawa, Kotaro
	NRID 1000020764062 1000020764062 researchmap permalink shuheiK shuheiK CreatorName Kawabata, Shuhei
	CreatorName Oguro-Igashira, Eri
	NRID 1000000464248 1000000464248 researchmap permalink neuroimmunology neuroimmunology Scopus Author ID 9736132000 9736132000 CreatorName Okuno, Tatsusada
	CreatorName Nii, Takuro
	NRID 1000010573222 1000010573222 researchmap permalink 101101101101101 101101101101101 Scopus Author ID 55363330100 55363330100 CreatorName Kinoshita, Makoto
	NRID 1000070724433 1000070724433 researchmap permalink osakansmt osakansmt Scopus Author ID 46261664000 46261664000 CreatorName Takagaki, Masatoshi
	NRID 1000090875585 1000090875585 ORCID 0000-0001-9594-7050 0000-0001-9594-7050 researchmap permalink KenichiYamamotoPed KenichiYamamotoPed Scopus Author ID 57204724143 57204724143 CreatorName Yamamoto, Kenichi
	NRID 1000030360481 1000030360481 ORCID 0000-0003-3966-3437 0000-0003-3966-3437 researchmap permalink norikoa norikoa Scopus Author ID 6701920120 6701920120 CreatorName Arase, Noriko
	CreatorName Yagita-Sakamaki, Mayu
	CreatorName Hosokawa, Akiko
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	NRID 1000030749114 1000030749114 researchmap permalink ymatsumoto43 ymatsumoto43 CreatorName Matsumoto, Yuki
	CreatorName Matsuoka, Hidetoshi
	CreatorName Yoshimura, Maiko
	NRID 1000050362728 1000050362728 CreatorName Ohshima, Shiro
	NRID 1000090432434 1000090432434 ORCID 0000-0003-2058-5942 0000-0003-2058-5942 researchmap permalink nkmrshota nkmrshota Scopus Author ID 35315778200 35315778200 CreatorName Nakamura, Shota
	NRID 1000090272591 1000090272591 ORCID 0000-0002-3062-4872 0000-0002-3062-4872 researchmap permalink read0122743 read0122743 Scopus Author ID 7401866712 7401866712 CreatorName Fujimoto, Manabu
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 CreatorName Inohara, Hidenori
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 CreatorName Mochizuki, Hideki
	NRID 1000020309446 1000020309446 ORCID 0000-0002-1778-6332 0000-0002-1778-6332 researchmap permalink read0118278 read0118278 Scopus Author ID 7404335442 7404335442 CreatorName Takeda, Kiyoshi
	NRID 1000010294125 1000010294125 researchmap permalink read0051725 read0051725 Scopus Author ID 6602726311 6602726311 ORCID 0000-0003-4749-7117 0000-0003-4749-7117 CreatorName Kumanogoh, Atsushi
	NRID 1000070727411 1000070727411 ORCID 0000-0002-0311-8472 0000-0002-0311-8472 researchmap permalink yokada yokada Scopus Author ID 35976475900 35976475900 CreatorName Okada, Yukinori
Subject	gut microbiome
	human genome
	plasma metabolites
	GWAS
	ABO blood types
Description	Tomofuji Yoshihiko, Kishikawa Toshihiro, Sonehara Kyuto, et al. Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population. Cell Reports 42, 113324 (2023); https://doi.org/10.1016/j.celrep.2023.113324.
Abstract	Interaction between the gut microbiome and host plays a key role in human health. Here, we perform a metagenome shotgun-sequencing-based analysis of Japanese participants to reveal associations between the gut microbiome, host genetics, and plasma metabolome. A genome-wide association study (GWAS) for microbial species (n = 524) identifies associations between the PDE1C gene locus and Bacteroides intestinalis and between TGIF2 and TGIF2-RAB5IF gene loci and Bacteroides acidifiaciens. In a microbial gene ortholog GWAS, agaE and agaS, which are related to the metabolism of carbohydrates forming the blood group A antigen, are associated with blood group A in a manner depending on the secretor status determined by the East Asian-specific FUT2 variant. A microbiome-metabolome association analysis (n = 261) identifies associations between bile acids and microbial features such as bile acid metabolism gene orthologs including bai and 7β-hydroxysteroid dehydrogenase. Our publicly available data will be a useful resource for understanding gut microbiome-host interactions in an underrepresented population.
Publisher	Elsevier BV
Source Title	Cell Reports
Volume (Issue)	42(11)
Page	113324
Date of Issued	2023-11-28
Language	English
Handle URL	https://hdl.handle.net/11094/93234
PISSN	22111247
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.celrep.2023.113324
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Cell Reports. 2023, 42(11), p. 113324
DC.title	Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population
DC.creator	Tomofuji, Yoshihiko
	Kishikawa, Toshihiro
	Sonehara, Kyuto
	Maeda, Yuichi
	Ogawa, Kotaro
	Kawabata, Shuhei
	Oguro-Igashira, Eri
	Okuno, Tatsusada
	Nii, Takuro
	Kinoshita, Makoto
	Takagaki, Masatoshi
	Yamamoto, Kenichi
	Arase, Noriko
	Yagita-Sakamaki, Mayu
	Hosokawa, Akiko
	Motooka, Daisuke
	Matsumoto, Yuki
	Matsuoka, Hidetoshi
	Yoshimura, Maiko
	Ohshima, Shiro
	Nakamura, Shota
	Fujimoto, Manabu
	Inohara, Hidenori
	Kishima, Haruhiko
	Mochizuki, Hideki
	Takeda, Kiyoshi
	Kumanogoh, Atsushi
	Okada, Yukinori
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-11-28
DC.identifier	https://doi.org/10.1016/j.celrep.2023.113324
DC.subject	gut microbiome
	human genome
	plasma metabolites
	GWAS
	ABO blood types
DC.description	Tomofuji Yoshihiko, Kishikawa Toshihiro, Sonehara Kyuto, et al. Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population. Cell Reports 42, 113324 (2023); https://doi.org/10.1016/j.celrep.2023.113324.
DCTERMS.abstract	Interaction between the gut microbiome and host plays a key role in human health. Here, we perform a metagenome shotgun-sequencing-based analysis of Japanese participants to reveal associations between the gut microbiome, host genetics, and plasma metabolome. A genome-wide association study (GWAS) for microbial species (n = 524) identifies associations between the PDE1C gene locus and Bacteroides intestinalis and between TGIF2 and TGIF2-RAB5IF gene loci and Bacteroides acidifiaciens. In a microbial gene ortholog GWAS, agaE and agaS, which are related to the metabolism of carbohydrates forming the blood group A antigen, are associated with blood group A in a manner depending on the secretor status determined by the East Asian-specific FUT2 variant. A microbiome-metabolome association analysis (n = 261) identifies associations between bile acids and microbial features such as bile acid metabolism gene orthologs including bai and 7β-hydroxysteroid dehydrogenase. Our publicly available data will be a useful resource for understanding gut microbiome-host interactions in an underrepresented population.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	93234
citation_title	Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population
citation_author	Tomofuji, Yoshihiko
	Kishikawa, Toshihiro
	Sonehara, Kyuto
	Maeda, Yuichi
	Ogawa, Kotaro
	Kawabata, Shuhei
	Oguro-Igashira, Eri
	Okuno, Tatsusada
	Nii, Takuro
	Kinoshita, Makoto
	Takagaki, Masatoshi
	Yamamoto, Kenichi
	Arase, Noriko
	Yagita-Sakamaki, Mayu
	Hosokawa, Akiko
	Motooka, Daisuke
	Matsumoto, Yuki
	Matsuoka, Hidetoshi
	Yoshimura, Maiko
	Ohshima, Shiro
	Nakamura, Shota
	Fujimoto, Manabu
	Inohara, Hidenori
	Kishima, Haruhiko
	Mochizuki, Hideki
	Takeda, Kiyoshi
	Kumanogoh, Atsushi
	Okada, Yukinori
citation_publisher	Elsevier BV
citation_language	English
citation_date	2023-11-28
citation_journal_title	Cell Reports
citation_volume	42
citation_issue	11
citation_firstpage	113324
citation_doi	https://doi.org/10.1016/j.celrep.2023.113324
citation_public_url	https://hdl.handle.net/11094/93234

Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population

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