Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

Nishigaki, Akari; Maruyama, Mihoko; Tanaka, Shun Ichi; Yoshikawa, Hiroshi Y; Imanishi, Masayuki; Yoshimura, Masashi; Mori, Yusuke; Takano, Kazufumi

doi:https://doi.org/10.3390/cryst11091069

Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

Nishigaki, Akari; Maruyama, Mihoko; Tanaka, Shun Ichi et al.

Crystals, 2021, 11(9), 1069

Number of Access:1,676（2025-08-14 06:28 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93289

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Title	Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel
Creator	CreatorName Nishigaki, Akari
	NRID 1000020623903 1000020623903 ORCID 0000-0002-3453-8007 0000-0002-3453-8007 researchmap permalink marumarumi marumarumi Scopus Author ID 35307485800 35307485800 CreatorName Maruyama, Mihoko
	NRID 1000070591387 1000070591387 CreatorName Tanaka, Shun Ichi
	NRID 1000050551173 1000050551173 researchmap permalink read0108058 read0108058 Scopus Author ID 55708129100 55708129100 ORCID 0000-0003-0624-6039 0000-0003-0624-6039 CreatorName Yoshikawa, Hiroshi Y
	NRID 1000000795487 1000000795487 researchmap permalink Na-flux Na-flux Scopus Author ID 55361211900 55361211900 ORCID 0000-0001-9395-1750 0000-0001-9395-1750 CreatorName Imanishi, Masayuki
	NRID 1000060314382 1000060314382 researchmap permalink read0191199 read0191199 Scopus Author ID 7403136552 7403136552 ORCID 0000-0002-0770-1251 0000-0002-0770-1251 CreatorName Yoshimura, Masashi
	NRID 1000090252618 1000090252618 ORCID 0000-0003-2952-7458 0000-0003-2952-7458 researchmap permalink mori_yusuke mori_yusuke Scopus Author ID 7404197134 7404197134 CreatorName Mori, Yusuke
	NRID 1000040346185 1000040346185 CreatorName Takano, Kazufumi
Subject	Diffusion
	Hydrogel
	Metastable phase
	Pharmaceutical compound
Description	Nishigaki A., Maruyama M., Tanaka S.I., et al. Growth of acetaminophen polymorphic crystals and solution-mediated phase transition from trihydrate to form II in agarose gel. Crystals 11, 1069 (2021); https://doi.org/10.3390/cryst11091069.
Abstract	The growth of acetaminophen polymorphic crystals and the solution-mediated phase transition from trihydrate to form II in agarose gel were investigated. The form II crystals grown in gels, presumably because of the agarose content, dissolved less rapidly at high temperatures and were more stable than in water. The trihydrate crystals in the gel were also expected to be stabilized by containing agarose, but in fact the fine morphology resulted in reduced stability. The solution-mediated phase transition from trihydrate to form II via form II seeding took longer in the gel because the gel slowed down the dissolution of the trihydrate by hindering the dispersion of the form II seeds and delayed the growth of form II by reducing the diffusion rate of the molecules dissolved from the trihydrate. Delays in solution-mediated phase transition and changes in stability for crystals grown in gels indicate the effectiveness of gels in controlling polymorphisms in pharmaceutical compounds.
Publisher	MDPI
Source Title	Crystals
Volume (Issue)	11(9)
Page	1069
Date of Issued	2021-09-05
Language	English
Handle URL	https://hdl.handle.net/11094/93289
eISSN	20734352
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/cryst11091069
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Crystals. 2021, 11(9), p. 1069
DC.title	Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel
DC.creator	Nishigaki, Akari
	Maruyama, Mihoko
	Tanaka, Shun Ichi
	Yoshikawa, Hiroshi Y
	Imanishi, Masayuki
	Yoshimura, Masashi
	Mori, Yusuke
	Takano, Kazufumi
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-09-05
DC.identifier	https://doi.org/10.3390/cryst11091069
DC.subject	Diffusion
	Hydrogel
	Metastable phase
	Pharmaceutical compound
DC.description	Nishigaki A., Maruyama M., Tanaka S.I., et al. Growth of acetaminophen polymorphic crystals and solution-mediated phase transition from trihydrate to form II in agarose gel. Crystals 11, 1069 (2021); https://doi.org/10.3390/cryst11091069.
DCTERMS.abstract	The growth of acetaminophen polymorphic crystals and the solution-mediated phase transition from trihydrate to form II in agarose gel were investigated. The form II crystals grown in gels, presumably because of the agarose content, dissolved less rapidly at high temperatures and were more stable than in water. The trihydrate crystals in the gel were also expected to be stabilized by containing agarose, but in fact the fine morphology resulted in reduced stability. The solution-mediated phase transition from trihydrate to form II via form II seeding took longer in the gel because the gel slowed down the dissolution of the trihydrate by hindering the dispersion of the form II seeds and delayed the growth of form II by reducing the diffusion rate of the molecules dissolved from the trihydrate. Delays in solution-mediated phase transition and changes in stability for crystals grown in gels indicate the effectiveness of gels in controlling polymorphisms in pharmaceutical compounds.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93289
citation_title	Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel
citation_author	Nishigaki, Akari
	Maruyama, Mihoko
	Tanaka, Shun Ichi
	Yoshikawa, Hiroshi Y
	Imanishi, Masayuki
	Yoshimura, Masashi
	Mori, Yusuke
	Takano, Kazufumi
citation_publisher	MDPI
citation_language	English
citation_date	2021-09-05
citation_journal_title	Crystals
citation_volume	11
citation_issue	9
citation_firstpage	1069
citation_doi	https://doi.org/10.3390/cryst11091069
citation_public_url	https://hdl.handle.net/11094/93289

Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

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