Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity

Abe, Kengo; Tsumaki, Noriyuki

Inflammation and Regeneration, 2023, 43(1), 56

Number of Access:209（2025-09-01 13:10 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93294

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Title
Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity
Creator
NRID
1000010983546 1000010983546
CreatorName
Abe, Kengo
NRID
1000050303938 1000050303938
ORCID
0000-0002-0520-3654 0000-0002-0520-3654
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Scopus Author ID
7004069586 7004069586
CreatorName
Tsumaki, Noriyuki
Subject
Allogeneic transplantation
Articular cartilage
Chondrocytes
Immune response
Induced pluripotent stem cells
Description
Abe K., Tsumaki N.. Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity. Inflammation and Regeneration 43, 56 (2023); https://doi.org/10.1186/s41232-023-00307-0.
Abstract
Background: Because of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged. Main body: Regenerative treatment is expected for the treatment of articular cartilage damage, and allogeneic chondrocytes or cartilage have an advantage over autologous chondrocytes, which are limited in number. However, the presence or absence of an immune response has not been analyzed and remains controversial. Allogeneic-induced pluripotent stem cell (iPSC)–derived cartilage, a new resource for cartilage regeneration, reportedly survived and integrated with native cartilage after transplantation into chondral defects in knee joints without immune rejection in a recent primate model. Here, we review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including iPSC-derived cartilage. Short conclusion: Allogeneic iPSC-derived cartilage transplantation, a new therapeutic option, could be a good indication for chondral defects, and the development of translational medical technology for articular cartilage damage is expected.
Publisher
BioMed Central Ltd
Source Title
Inflammation and Regeneration
Volume (Issue)
43(1)
Page
56
Date of Issued
2023-11-14
Language
English
Handle URL
https://hdl.handle.net/11094/93294
eISSN
18808190
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1186/s41232-023-00307-0
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article