Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer

Hamada, Masakazu; Inaba, Hiroaki; Nishiyama, Kyoko et al.

International Journal of Molecular Sciences, 2023, 24(20), 15456

Number of Access:63（2025-05-16 15:27 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93321

Link to primary information 

File Format Terms of use Size Views Date.Available Description information
IntJMolSci_24_20_15456 pdf None 3.66 MB 86 2023.12.19  
Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title
Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer
Creator
NRID
1000080506361 1000080506361
researchmap permalink
6361 6361
Scopus Author ID
36616148000 36616148000
CreatorName
Hamada, Masakazu
NRID
1000070359850 1000070359850
CreatorName
Inaba, Hiroaki
NRID
1000070846542 1000070846542
researchmap permalink
02205 02205
CreatorName
Nishiyama, Kyoko
NRID
1000040801048 1000040801048
CreatorName
Yoshida, Sho
NRID
1000000136277 1000000136277
CreatorName
Yura, Yoshiaki
NRID
1000030359848 1000030359848
CreatorName
Matsumoto-Nakano, Michiyo
NRID
1000030345285 1000030345285
researchmap permalink
read0212957 read0212957
Scopus Author ID
6603144046 6603144046
CreatorName
Uzawa, Narikazu
Subject
head and neck squamous cell carcinoma
intratumor microbiome
Leptotrichia
oral bacteria
RNA sequencing
TCGA
TCMA
Description
Hamada M., Inaba H., Nishiyama K., et al. Potential Role of the Intratumoral Microbiota in Prognosis of Head and Neck Cancer. International Journal of Molecular Sciences 24, 15456 (2023); https://doi.org/10.3390/ijms242015456.
Abstract
The tumor microbiome, a relatively new research field, affects tumor progression through several mechanisms. The Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and The Cancer Genome Atlas and examined microbiome profiling in head and neck squamous cell carcinoma (HNSCC), the role of the intratumoral microbiota in the prognosis of HNSCC patients, and differentially expressed genes in tumor cells in relation to specific bacterial infections. We investigated 18 microbes at the genus level that differed between solid normal tissue (n = 22) and primary tumors (n = 154). The tissue microbiome profiles of Actinomyces, Fusobacterium, and Rothia at the genus level differed between the solid normal tissue and primary tumors of HNSCC patients. When the prognosis of groups with rates over and under the median for each microbe at the genus level was examined, rates for Leptotrichia which were over the median correlated with significantly higher overall survival rates. We then extracted 35 differentially expressed genes between the over- and under-the-median-for-Leptotrichia groups based on the criteria of >1.5 fold and p < 0.05 in the Mann–Whitney U-test. A pathway analysis showed that these Leptotrichia-related genes were associated with the pathways of Alzheimer disease, neurodegeneration-multiple diseases, prion disease, MAPK signaling, and PI3K-Akt signaling, while protein–protein interaction analysis revealed that these genes formed a dense network. In conclusion, probiotics and specific antimicrobial therapy targeting Leptotrichia may have an impact on the prognosis of HNSCC.
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Source Title
International Journal of Molecular Sciences
Volume (Issue)
24(20)
Page
15456
Date of Issued
2023-10-22
Language
English
Handle URL
https://hdl.handle.net/11094/93321
PISSN
16616596
eISSN
14220067
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/ijms242015456
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article