Involvement of Mitochondria in Parkinson’s Disease

Choong, Chi Jing; Mochizuki, Hideki

doi:https://doi.org/10.3390/ijms242317027

Involvement of Mitochondria in Parkinson’s Disease

Choong, Chi Jing; Mochizuki, Hideki

International Journal of Molecular Sciences, 2023, 24(23), 17027

Number of Access:408（2025-07-22 00:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93388

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Title	Involvement of Mitochondria in Parkinson’s Disease
Creator	NRID 1000050796076 1000050796076 researchmap permalink choongcj choongcj CreatorName Choong, Chi Jing
Creator	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 CreatorName Mochizuki, Hideki
Subject	extracellular mitochondria
	mitochondria
	mitochondria transplantation
	Parkin
	Parkinson’s disease
	PINK1
Description	Choong C.J., Mochizuki H.. Involvement of Mitochondria in Parkinson’s Disease. International Journal of Molecular Sciences 24, 17027 (2023); https://doi.org/10.3390/ijms242317027.
Abstract	Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been implicated in the pathogenesis of PD. Initiating from the observation that mitochondrial toxins cause PD-like symptoms and mitochondrial DNA mutations are associated with increased risk of PD, many mutated genes linked to familial forms of PD, including PRKN, PINK1, DJ-1 and SNCA, have also been found to affect the mitochondrial features. Recent research has uncovered a much more complex involvement of mitochondria in PD. Disruption of mitochondrial quality control coupled with abnormal secretion of mitochondrial contents to dispose damaged organelles may play a role in the pathogenesis of PD. Furthermore, due to its bacterial ancestry, circulating mitochondrial DNAs can function as damage-associated molecular patterns eliciting inflammatory response. In this review, we summarize and discuss the connection between mitochondrial dysfunction and PD, highlighting the molecular triggers of the disease process, the intra- and extracellular roles of mitochondria in PD as well as the therapeutic potential of mitochondrial transplantation.
Publisher	Multidisciplinary Digital Publishing Institute (MDPI)
Source Title	International Journal of Molecular Sciences
Volume (Issue)	24(23)
Page	17027
Date of Issued	2023-12-01
Language	English
Handle URL	https://hdl.handle.net/11094/93388
PISSN	16616596
eISSN	14220067
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.3390/ijms242317027
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	International Journal of Molecular Sciences. 2023, 24(23), p. 17027
DC.title	Involvement of Mitochondria in Parkinson’s Disease
DC.creator	Choong, Chi Jing
DC.creator	Mochizuki, Hideki
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-12-01
DC.identifier	https://doi.org/10.3390/ijms242317027
DC.subject	extracellular mitochondria
	mitochondria
	mitochondria transplantation
	Parkin
	Parkinson’s disease
	PINK1
DC.description	Choong C.J., Mochizuki H.. Involvement of Mitochondria in Parkinson’s Disease. International Journal of Molecular Sciences 24, 17027 (2023); https://doi.org/10.3390/ijms242317027.
DCTERMS.abstract	Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been implicated in the pathogenesis of PD. Initiating from the observation that mitochondrial toxins cause PD-like symptoms and mitochondrial DNA mutations are associated with increased risk of PD, many mutated genes linked to familial forms of PD, including PRKN, PINK1, DJ-1 and SNCA, have also been found to affect the mitochondrial features. Recent research has uncovered a much more complex involvement of mitochondria in PD. Disruption of mitochondrial quality control coupled with abnormal secretion of mitochondrial contents to dispose damaged organelles may play a role in the pathogenesis of PD. Furthermore, due to its bacterial ancestry, circulating mitochondrial DNAs can function as damage-associated molecular patterns eliciting inflammatory response. In this review, we summarize and discuss the connection between mitochondrial dysfunction and PD, highlighting the molecular triggers of the disease process, the intra- and extracellular roles of mitochondria in PD as well as the therapeutic potential of mitochondrial transplantation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93388
citation_title	Involvement of Mitochondria in Parkinson’s Disease
citation_author	Choong, Chi Jing
citation_author	Mochizuki, Hideki
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	English
citation_date	2023-12-01
citation_journal_title	International Journal of Molecular Sciences
citation_volume	24
citation_issue	23
citation_firstpage	17027
citation_doi	https://doi.org/10.3390/ijms242317027
citation_public_url	https://hdl.handle.net/11094/93388

Involvement of Mitochondria in Parkinson’s Disease

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