Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice

Yasuda, Shumpei P.; Miyasaka, Yuki; Hou, Xuehan et al.

Biomedicines, 2022, 10(9), 2221

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Identifier to cite or link to this item: https://hdl.handle.net/11094/93410

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Title
Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice
Creator
NRID
1000050534012 1000050534012
CreatorName
Yasuda, Shumpei P.
CreatorName
Miyasaka, Yuki
CreatorName
Hou, Xuehan
CreatorName
Obara, Yo
CreatorName
Shitara, Hiroshi
NRID
1000010615636 1000010615636
CreatorName
Seki, Yuta
NRID
1000040291158 1000040291158
CreatorName
Matsuoka, Kunie
CreatorName
Takahashi, Ai
NRID
1000040964896 1000040964896
researchmap permalink
eri_wakai eri_wakai
CreatorName
Wakai, Eri
NRID
1000070314317 1000070314317
researchmap permalink
hiroshi_hibino hiroshi_hibino
Scopus Author ID
7007020846 7007020846
CreatorName
Hibino, Hiroshi
NRID
1000020356257 1000020356257
CreatorName
Takada, Toyoyuki
NRID
1000090171058 1000090171058
CreatorName
Shiroishi, Toshihiko
NRID
1000040133615 1000040133615
CreatorName
Kominami, Ryo
NRID
1000020280787 1000020280787
CreatorName
Kikkawa, Yoshiaki
Subject
age-related hearing loss
ahl loci
C57BL/6J strain
congenic strain
consomic strain
MSM/Ms strain
Description
Yasuda S.P., Miyasaka Y., Hou X., et al. Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice. Biomedicines 10, 2221 (2022); https://doi.org/10.3390/biomedicines10092221.
Abstract
An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to age-related hearing loss, and their auditory abilities are sustained for long durations. The age-related hearing loss 3 (ahl3) locus contributes to age-related hearing in MSM/Ms strain. We generated ahl3 congenic strains by transferring a genomic region on chromosome 17 from MSM/Ms mice into C57BL/6J mice. Although C57BL/6J mice develop age-related hearing loss because of the ahl allele of the cadherin 23 gene, the development of middle- to high-frequency hearing loss was significantly delayed in an ahl3 congenic strain. Moreover, the novel age-related hearing loss 10 (ahl10) locus associated with age-related hearing resistance in MSM/Ms strain was mapped to chromosome 12. Although the resistance effects in ahl10 congenic strain were slightly weaker than those in ahl3 congenic strain, slow progression of age-related hearing loss was confirmed in ahl10 congenic strain despite harboring the ahl allele of cadherin 23. These results suggest that causative genes and polymorphisms of the ahl3 and ahl10 loci are important targets for the prevention and treatment of age-related hearing loss.
Publisher
MDPI
Source Title
Biomedicines
Volume (Issue)
10(9)
Page
2221
Date of Issued
2022-09-07
Language
English
Handle URL
https://hdl.handle.net/11094/93410
eISSN
22279059
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3390/biomedicines10092221
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Version of Record
Category
学術雑誌論文 Journal Article