Analysis of Pharmacokinetics in the Cochlea of the Inner Ear

Sawamura, Seishiro; Ogata, Genki; Asai Kai et al.

Frontiers in Pharmacology, 2021, 12, 633505

Number of Access:1,559（2025-07-26 17:21 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93412

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Title
Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
Creator
NRID
1000010781974 1000010781974
Scopus Author ID
57190878168 57190878168
CreatorName
Sawamura, Seishiro
NRID
1000080452829 1000080452829
CreatorName
Ogata, Genki
CreatorName
Asai Kai
CreatorName
Razvina, Olga
NRID
1000030790571 1000030790571
ORCID
0000-0003-0011-8925 0000-0003-0011-8925
researchmap permalink
otatakeru otatakeru
Scopus Author ID
26642091900 26642091900
CreatorName
Ota, Takeru
CreatorName
Zhang, Qi
CreatorName
Madhurantakam, Sasya
CreatorName
Akiyama, Koei
NRID
1000040721981 1000040721981
ORCID
0000-0002-8112-0746 0000-0002-8112-0746
researchmap permalink
daisukeino daisukeino
CreatorName
Ino, Daisuke
NRID
1000050286556 1000050286556
CreatorName
Kanzaki, Sho
NRID
1000090865057 1000090865057
CreatorName
Saiki, Takuro
NRID
1000060770211 1000060770211
CreatorName
Matsumoto, Yoshifumi
NRID
1000030598131 1000030598131
CreatorName
Moriyama, Masato
NRID
1000010270828 1000010270828
CreatorName
Saijo, Yasuo
NRID
1000030294060 1000030294060
CreatorName
Horii, Arata
NRID
1000000322066 1000000322066
CreatorName
Einaga, Yasuaki
NRID
1000070314317 1000070314317
researchmap permalink
hiroshi_hibino hiroshi_hibino
Scopus Author ID
7007020846 7007020846
CreatorName
Hibino, Hiroshi
Subject
cochlea
ototoxic drug
pharmacokinetics
real-time measurement
sensorineural hearing loss
therapeutic reagent
Description
Sawamura S., Ogata G., Asai K., et al. Analysis of Pharmacokinetics in the Cochlea of the Inner Ear. Frontiers in Pharmacology 12, 633505 (2021); https://doi.org/10.3389/fphar.2021.633505.
Abstract
Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of drugs, stems primarily from a dysfunction of the cochlea in the inner ear. Few therapeutic strategies against sensorineural hearing loss are available. To develop effective treatments for this disease, it is crucial to precisely determine the behavior of ototoxic and therapeutic agents in the microenvironment of the cochlea in live animals. Since the 1980s, a number of studies have addressed this issue by different methodologies. However, there is much less information on pharmacokinetics in the cochlea than that in other organs; the delay in ontological pharmacology is likely due to technical difficulties with accessing the cochlea, a tiny organ that is encased with a bony wall and has a fine and complicated internal structure. In this review, we not only summarize the observations and insights obtained in classic and recent studies on pharmacokinetics in the cochlea but also describe relevant analytical techniques, with their strengths, limitations, and prospects.
Publisher
Frontiers Media S.A.
Source Title
Frontiers in Pharmacology
Volume (Issue)
12
Page
633505
Date of Issued
2021-05-03
Language
English
Handle URL
https://hdl.handle.net/11094/93412
eISSN
16639812
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.3389/fphar.2021.633505
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Version of Record
Category
学術雑誌論文 Journal Article