Characterisation of the static offset in the travelling wave in the cochlear basal turn

Ota, Takeru; Nin, Fumiaki; Choi, Samuel; Muramatsu, Shogo; Sawamura, Seishiro; Ogata, Genki; Sato, Mitsuo P.; Doi, Katsumi; Doi, Kentaro; Tsuji, Tetsuro; Kawano, Satoyuki; Reichenbach, Tobias; Hibino, Hiroshi

doi:https://doi.org/10.1007/s00424-020-02373-6

Characterisation of the static offset in the travelling wave in the cochlear basal turn

Ota, Takeru; Nin, Fumiaki; Choi, Samuel et al.

Pflugers Archiv European Journal of Physiology, 2020, 472(5), 625-635

Number of Access:1,277（2025-08-14 15:05 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93415

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Title	Characterisation of the static offset in the travelling wave in the cochlear basal turn
Creator	NRID 1000030790571 1000030790571 ORCID 0000-0003-0011-8925 0000-0003-0011-8925 researchmap permalink otatakeru otatakeru Scopus Author ID 26642091900 26642091900 CreatorName Ota, Takeru
	NRID 1000080644905 1000080644905 CreatorName Nin, Fumiaki
	NRID 1000060568418 1000060568418 CreatorName Choi, Samuel
	NRID 1000030295472 1000030295472 CreatorName Muramatsu, Shogo
	NRID 1000010781974 1000010781974 Scopus Author ID 57190878168 57190878168 CreatorName Sawamura, Seishiro
	NRID 1000080452829 1000080452829 CreatorName Ogata, Genki
	CreatorName Sato, Mitsuo P.
	NRID 1000040243224 1000040243224 CreatorName Doi, Katsumi
	CreatorName Doi, Kentaro
	NRID 1000000708670 1000000708670 CreatorName Tsuji, Tetsuro
	NRID 1000000250837 1000000250837 researchmap permalink read0180299 read0180299 Scopus Author ID 56192450900 56192450900 CreatorName Kawano, Satoyuki
	CreatorName Reichenbach, Tobias
	NRID 1000070314317 1000070314317 researchmap permalink hiroshi_hibino hiroshi_hibino Scopus Author ID 7007020846 7007020846 CreatorName Hibino, Hiroshi
Subject	Offset
	Outer hair cells
	Somatic motility
	Travelling wave
	Vibration
Description	The version of record of this article, first published in Pflugers Archiv European Journal of Physiology, is available online at Publisher’s website: https://doi.org/10.1007/s00424-020-02373-6.
Abstract	In mammals, audition is triggered by travelling waves that are evoked by acoustic stimuli in the cochlear partition, a structure containing sensory hair cells and a basilar membrane. When the cochlea is stimulated by a pure tone of low frequency, a static offset occurs in the vibration in the apical turn. In the high-frequency region at the cochlear base, multi-tone stimuli induce a quadratic distortion product in the vibrations that suggests the presence of an offset. However, vibrations below 100 Hz, including a static offset, have not been directly measured there. We therefore constructed an interferometer for detecting motion at low frequencies including 0 Hz. We applied the interferometer to record vibrations from the cochlear base of guinea pigs in response to pure tones. When the animals were exposed to sound at an intensity of 70 dB or higher, we recorded a static offset of the sinusoidally vibrating cochlear partition by more than 1 nm towards the scala vestibuli. The offset’s magnitude grew monotonically as the stimuli intensified. When stimulus frequency was varied, the response peaked around the best frequency, the frequency that maximised the vibration amplitude at threshold sound pressure. These characteristics are consistent with those found in the low-frequency region and are therefore likely common across the cochlea. The offset diminished markedly when the somatic motility of mechanosensitive outer hair cells, the force-generating machinery that amplifies the sinusoidal vibrations, was pharmacologically blocked. Therefore, the partition offset appears to be linked to the electromotile contraction of outer hair cells.
Publisher	Springer
Source Title	Pflugers Archiv European Journal of Physiology
Volume (Issue)	472(5)
Page	625-635
Date of Issued	2020-05-01
Language	English
Handle URL	https://hdl.handle.net/11094/93415
PISSN	00316768
eISSN	14322013
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00424-020-02373-6
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Pflugers Archiv European Journal of Physiology. 2020, 472(5), p. 625-635
DC.title	Characterisation of the static offset in the travelling wave in the cochlear basal turn
DC.creator	Ota, Takeru
	Nin, Fumiaki
	Choi, Samuel
	Muramatsu, Shogo
	Sawamura, Seishiro
	Ogata, Genki
	Sato, Mitsuo P.
	Doi, Katsumi
	Doi, Kentaro
	Tsuji, Tetsuro
	Kawano, Satoyuki
	Reichenbach, Tobias
	Hibino, Hiroshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-05-01
DC.identifier	https://doi.org/10.1007/s00424-020-02373-6
DC.subject	Offset
	Outer hair cells
	Somatic motility
	Travelling wave
	Vibration
DC.description	The version of record of this article, first published in Pflugers Archiv European Journal of Physiology, is available online at Publisher’s website: https://doi.org/10.1007/s00424-020-02373-6.
DCTERMS.abstract	In mammals, audition is triggered by travelling waves that are evoked by acoustic stimuli in the cochlear partition, a structure containing sensory hair cells and a basilar membrane. When the cochlea is stimulated by a pure tone of low frequency, a static offset occurs in the vibration in the apical turn. In the high-frequency region at the cochlear base, multi-tone stimuli induce a quadratic distortion product in the vibrations that suggests the presence of an offset. However, vibrations below 100 Hz, including a static offset, have not been directly measured there. We therefore constructed an interferometer for detecting motion at low frequencies including 0 Hz. We applied the interferometer to record vibrations from the cochlear base of guinea pigs in response to pure tones. When the animals were exposed to sound at an intensity of 70 dB or higher, we recorded a static offset of the sinusoidally vibrating cochlear partition by more than 1 nm towards the scala vestibuli. The offset’s magnitude grew monotonically as the stimuli intensified. When stimulus frequency was varied, the response peaked around the best frequency, the frequency that maximised the vibration amplitude at threshold sound pressure. These characteristics are consistent with those found in the low-frequency region and are therefore likely common across the cochlea. The offset diminished markedly when the somatic motility of mechanosensitive outer hair cells, the force-generating machinery that amplifies the sinusoidal vibrations, was pharmacologically blocked. Therefore, the partition offset appears to be linked to the electromotile contraction of outer hair cells.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93415
citation_title	Characterisation of the static offset in the travelling wave in the cochlear basal turn
citation_author	Ota, Takeru
	Nin, Fumiaki
	Choi, Samuel
	Muramatsu, Shogo
	Sawamura, Seishiro
	Ogata, Genki
	Sato, Mitsuo P.
	Doi, Katsumi
	Doi, Kentaro
	Tsuji, Tetsuro
	Kawano, Satoyuki
	Reichenbach, Tobias
	Hibino, Hiroshi
citation_publisher	Springer
citation_language	English
citation_date	2020-05-01
citation_journal_title	Pflugers Archiv European Journal of Physiology
citation_volume	472
citation_issue	5
citation_firstpage	625
citation_lastpage	635
citation_doi	https://doi.org/10.1007/s00424-020-02373-6
citation_public_url	https://hdl.handle.net/11094/93415

Characterisation of the static offset in the travelling wave in the cochlear basal turn

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