In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope

Choi, Samuel; Nin, Fumiaki; Ota, Takeru et al.

Biomedical Optics Express, 2019, 10(7), 3317-3342

Number of Access:789（2025-08-13 22:16 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93417

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Title
In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope
Creator
NRID
1000060568418 1000060568418
CreatorName
Choi, Samuel
NRID
1000080644905 1000080644905
CreatorName
Nin, Fumiaki
NRID
1000030790571 1000030790571
ORCID
0000-0003-0011-8925 0000-0003-0011-8925
researchmap permalink
otatakeru otatakeru
Scopus Author ID
26642091900 26642091900
CreatorName
Ota, Takeru
CreatorName
Sato, Kouhei
NRID
1000030295472 1000030295472
CreatorName
Muramatsu, Shogo
NRID
1000070314317 1000070314317
researchmap permalink
hiroshi_hibino hiroshi_hibino
Scopus Author ID
7007020846 7007020846
CreatorName
Hibino, Hiroshi
Description
Choi S., Nin F., Ota T., et al. In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope. Biomedical Optics Express 10, 3317 (2019); https://doi.org/10.1364/BOE.10.003317.
Abstract
This study combined a previously developed optical system with two additional key elements: a supercontinuum light source characterized by high output power and an analytical technique that effectively extracts interference signals required for improving the detection limit of vibration amplitude. Our system visualized 3D tomographic images and nanometer scale vibrations in the cochlear sensory epithelium of a live guinea pig. The transverse- and axial-depth resolution was 3.6 and 2.7 µm, respectively. After exposure to acoustic stimuli of 21-25 kHz at a sound pressure level of 70-85 dB, spatial amplitude and phase distributions were quantified on a targeted surface, whose area was 522 × 522 µm2.
Publisher
OPTICA Publishing Group
Source Title
Biomedical Optics Express
Volume (Issue)
10(7)
Page
3317-3342
Date of Issued
2019-07-01
Language
English
Handle URL
https://hdl.handle.net/11094/93417
eISSN
21567085
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1364/BOE.10.003317
Access Rights
open access
CopyRight
© 2019 Optica Publishing Group. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article