journal article

Journal Article

Text

Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2024, 112(1), p. e35365

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

John Wiley and Sons Inc

English

Text

2024-01-01

https://doi.org/10.1002/jbm.b.35365

This is the peer reviewed version of the following article: Abe G.L., Sasaki J.I., Tsuboi R., et al. Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35365 (2024), which has been published in final form at https://doi.org/10.1002/jbm.b.35365. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Guided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow-degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL) was used to prepare a slow-degrading bilayer membrane. The biodegradability of PLCL was evaluated by subcutaneous implantation in a rat model. The barrier function of the PLCL membrane was investigated in a rat calvaria defect model and compared with commercially available membranes composed of type I collagen (Col) and poly(lactic-co-glycolic acid) (PLGA). An alveolar bone defect model in beagle dogs was used to simulate GBR protocols to evaluate the bone regeneration ability of the experimental PLCL membrane. The PLCL membrane showed slow biodegradation, resulting in an efficient and prolonged barrier function compared with commercial materials. In turn, this barrier function enabled the space-making ability of PLCL membrane and facilitated bone regeneration. In the alveolar bone defect model, significantly greater regeneration was achieved by treatment with PLCL membrane compared with Col and PLGA membranes. Additionally, a continuous alveolar ridge contour was observed in PLCL-treated bone defects. In conclusion, the PLCL bilayer membrane is a promising biomaterial for use in GBR given its slow degradation and prolonged barrier function.

© 2023 Wiley Periodicals LLC.

93453

Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function

John Wiley and Sons Inc

English

2024-01-01

Journal of Biomedical Materials Research - Part B Applied Biomaterials

112

1

e35365

https://doi.org/10.1002/jbm.b.35365

https://hdl.handle.net/11094/93453