Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics

Otani, Tomohiro; Miyata, Kota; Miki, Atsuya et al.

Medical Engineering and Physics, 2024, 123, 104086

Number of Access:439（2025-08-28 20:55 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93456

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Title
Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics
Creator
NRID
1000040778990 1000040778990
ORCID
0000-0002-6431-2703 0000-0002-6431-2703
researchmap permalink
bigvalley bigvalley
Scopus Author ID
55625962900 55625962900
CreatorName
Otani, Tomohiro
CreatorName
Miyata, Kota
NRID
1000030437404 1000030437404
CreatorName
Miki, Atsuya
NRID
1000070240546 1000070240546
researchmap permalink
shigeo41010 shigeo41010
Scopus Author ID
7401983636 7401983636
CreatorName
Wada, Shigeo
Subject
Central retinal vessel
Glaucoma
Optic nerves head
Optical coherence tomography
Smoothed finite element method
Description
Otani T., Miyata K., Miki A., et al. Computational study on the effects of central retinal blood vessels with asymmetric geometries on optic nerve head biomechanics. Medical Engineering and Physics 123, 104086 (2024); https://doi.org/10.1016/j.medengphy.2023.104086.
Abstract
Optic nerve head (ONH) biomechanics are associated with glaucoma progression and have received considerable attention. Central retinal vessels (CRVs) oriented asymmetrically in the ONH are the single blood supply source to the retina and are believed to act as mechanically stable elements in the ONH in response to intraocular pressure (IOP). However, these mechanical effects are considered negligible in ONH biomechanical studies and received less attention. This study investigated the effects of CRVs on ONH biomechanics taking into consideration three-dimensional asymmetric CRV geometries. A CRV geometry was constructed based on CRV centerlines extracted from optical coherence tomography ONH images in eight healthy subjects and superimposed in the idealized ONH geometry established in previous studies. Mechanical analyses of the ONH in response to the IOP were conducted in the cases with and without CRVs for comparison. Obtained results demonstrated that the CRVs induced anisotropic ONH deformation, particularly in the lamina cribrosa and the associated upper neural tissues (prelamina) with wide ranges of spatial strain distributions. These results indicated that the CRVs result in anisotropic deformation with local strain concentration, rather than function to mechanically support in response to the IOP as in the conventional thinking in ophthalmology.
Publisher
Elsevier Ltd
Source Title
Medical Engineering and Physics
Volume (Issue)
123
Page
104086
Date of Issued
2024-01-01
Language
English
Handle URL
https://hdl.handle.net/11094/93456
PISSN
13504533
eISSN
18734030
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1016/j.medengphy.2023.104086
Access Rights
open access
CopyRight
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article