An easy-to-implement, non-invasive head restraint method for monkey fMRI

Tanaka, Reiji; Watanabe, Kei; Suzuki, Takafumi; Nakamura, Kae; Yasuda, Masaharu; Ban, Hiroshi; Okada, Ken-ichi; Kitazawa, Shigeru

doi:https://doi.org/10.1016/j.neuroimage.2023.120479

An easy-to-implement, non-invasive head restraint method for monkey fMRI

Tanaka, Reiji; Watanabe, Kei; Suzuki, Takafumi et al.

NeuroImage, 2024, 285, 120479

Number of Access:990（2025-08-16 05:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93522

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Title	An easy-to-implement, non-invasive head restraint method for monkey fMRI
Creator	CreatorName Tanaka, Reiji
	NRID 1000000772740 1000000772740 ORCID 0000-0002-3790-1078 0000-0002-3790-1078 researchmap permalink geo geo Scopus Author ID 56044938400 56044938400 CreatorName Watanabe, Kei
	CreatorName Suzuki, Takafumi
	NRID 1000040454607 1000040454607 CreatorName Nakamura, Kae
	NRID 1000090744110 1000090744110 CreatorName Yasuda, Masaharu
	NRID 1000000467391 1000000467391 CreatorName Ban, Hiroshi
	NRID 1000080790956 1000080790956 CreatorName Okada, Ken-ichi
	NRID 1000000251231 1000000251231 researchmap permalink shigerukitazawa shigerukitazawa Scopus Author ID 36865431600 36865431600 CreatorName Kitazawa, Shigeru
Subject	fMRI
	Monkey
	non-invasive
Description	Tanaka R., Watanabe K., Suzuki T., et al. An easy-to-implement, non-invasive head restraint method for monkey fMRI. NeuroImage 285, 120479 (2024); https://doi.org/10.1016/j.neuroimage.2023.120479.
Abstract	Functional magnetic resonance imaging (fMRI) in behaving monkeys has a strong potential to bridge the gap between human neuroimaging and primate neurophysiology. In monkey fMRI, to restrain head movements, researchers usually surgically implant a plastic head-post on the skull. Although time-proven to be effective, this technique could create burdens for animals, including a risk of infection and discomfort. Furthermore, the presence of extraneous objects on the skull, such as bone screws and dental cement, adversely affects signals near the cortical surface. These side effects are undesirable in terms of both the practical aspect of efficient data collection and the spirit of “refinement” from the 3R's. Here, we demonstrate that a completely non-invasive fMRI scan in awake monkeys is possible by using a plastic head mask made to fit the skull of individual animals. In all of the three monkeys tested, longitudinal, quantitative assessment of head movements showed that the plastic mask has effectively suppressed head movements, and we were able to obtain reliable retinotopic BOLD signals in a standard retinotopic mapping task. The present, easy-to-make plastic mask has a strong potential to simplify fMRI experiments in awake monkeys, while giving data that is as good as or even better quality than that obtained with the conventional head-post method.
Publisher	Academic Press Inc.
Source Title	NeuroImage
Volume (Issue)	285
Page	120479
Date of Issued	2024-01-01
Language	English
Handle URL	https://hdl.handle.net/11094/93522
PISSN	10538119
eISSN	10959572
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.neuroimage.2023.120479
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	NeuroImage. 2024, 285, p. 120479
DC.title	An easy-to-implement, non-invasive head restraint method for monkey fMRI
DC.creator	Tanaka, Reiji
	Watanabe, Kei
	Suzuki, Takafumi
	Nakamura, Kae
	Yasuda, Masaharu
	Ban, Hiroshi
	Okada, Ken-ichi
	Kitazawa, Shigeru
DC.publisher	Academic Press Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-01
DC.identifier	https://doi.org/10.1016/j.neuroimage.2023.120479
DC.subject	fMRI
	Monkey
	non-invasive
DC.description	Tanaka R., Watanabe K., Suzuki T., et al. An easy-to-implement, non-invasive head restraint method for monkey fMRI. NeuroImage 285, 120479 (2024); https://doi.org/10.1016/j.neuroimage.2023.120479.
DCTERMS.abstract	Functional magnetic resonance imaging (fMRI) in behaving monkeys has a strong potential to bridge the gap between human neuroimaging and primate neurophysiology. In monkey fMRI, to restrain head movements, researchers usually surgically implant a plastic head-post on the skull. Although time-proven to be effective, this technique could create burdens for animals, including a risk of infection and discomfort. Furthermore, the presence of extraneous objects on the skull, such as bone screws and dental cement, adversely affects signals near the cortical surface. These side effects are undesirable in terms of both the practical aspect of efficient data collection and the spirit of “refinement” from the 3R's. Here, we demonstrate that a completely non-invasive fMRI scan in awake monkeys is possible by using a plastic head mask made to fit the skull of individual animals. In all of the three monkeys tested, longitudinal, quantitative assessment of head movements showed that the plastic mask has effectively suppressed head movements, and we were able to obtain reliable retinotopic BOLD signals in a standard retinotopic mapping task. The present, easy-to-make plastic mask has a strong potential to simplify fMRI experiments in awake monkeys, while giving data that is as good as or even better quality than that obtained with the conventional head-post method.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	93522
citation_title	An easy-to-implement, non-invasive head restraint method for monkey fMRI
citation_author	Tanaka, Reiji
	Watanabe, Kei
	Suzuki, Takafumi
	Nakamura, Kae
	Yasuda, Masaharu
	Ban, Hiroshi
	Okada, Ken-ichi
	Kitazawa, Shigeru
citation_publisher	Academic Press Inc.
citation_language	English
citation_date	2024-01-01
citation_journal_title	NeuroImage
citation_volume	285
citation_firstpage	120479
citation_doi	https://doi.org/10.1016/j.neuroimage.2023.120479
citation_public_url	https://hdl.handle.net/11094/93522

An easy-to-implement, non-invasive head restraint method for monkey fMRI

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