Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Suyama, Ritsuko; Cetraro, Nicolas; Yew, Joanne Y. et al.

Communications Biology, 2023, 6(1), 1287

Number of Access:386（2025-09-05 08:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93535

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Title
Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways
Creator
NRID
1000030574652 1000030574652
researchmap permalink
rsuyama rsuyama
ORCID
0000-0001-6154-208X 0000-0001-6154-208X
CreatorName
Suyama, Ritsuko
CreatorName
Cetraro, Nicolas
CreatorName
Yew, Joanne Y.
NRID
1000040579786 1000040579786
ORCID
0000-0001-8675-8469 0000-0001-8675-8469
researchmap permalink
toshie_kai toshie_kai
Scopus Author ID
7102037941 7102037941
CreatorName
Kai, Toshie
Description
Suyama R., Cetraro N., Yew J.Y., et al. Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways. Communications Biology 6, 1287 (2023); https://doi.org/10.1038/S42003-023-05660-X.
Abstract
Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and enhancing fertility under poor nutrition conditions. However, detailed molecular mechanisms by which microbes control germline maturation, leading to reproduction, remain largely unknown. In this study, we show that environmental microbes exert a beneficial effect on Drosophila oogenesis by promoting germline stem cell (GSC) proliferation and subsequent egg maturation via acceleration of ovarian cell division and suppression of apoptosis. Moreover, insulin-related signaling is not required; rather, the ecdysone pathway is necessary for microbe-induced increase of GSCs and promotion of egg maturation, while juvenile hormone contributes only to increasing GSC numbers, suggesting that hormonal pathways are activated at different stages of oogenesis. Our findings reveal that environmental microbes can enhance host reproductivity by modulating host hormone release and promoting oogenesis.
Publisher
Nature Research
Source Title
Communications Biology
Volume (Issue)
6(1)
Page
1287
Date of Issued
2023-12-20
Language
English
Handle URL
https://hdl.handle.net/11094/93535
eISSN
23993642
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/S42003-023-05660-X
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article