Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan

Hayano, Eri; Gon, Yasufumi; Kimura, Yasuyoshi; Zha, Ling; Morishima, Toshitaka; Ohno, Yuko; Mochizuki, Hideki; Sobue, Tomotaka; Miyashiro, Isao

doi:https://doi.org/10.1016/j.parkreldis.2023.105966

Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan

Hayano, Eri; Gon, Yasufumi; Kimura, Yasuyoshi et al.

Parkinsonism and Related Disorders, 2024, 119, 105966

Number of Access:1,404（2025-12-11 21:31 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/93536

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Title	Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan
Creator	CreatorName Hayano, Eri
	NRID 1000070751311 1000070751311 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 ORCID 0000-0002-3907-1741 0000-0002-3907-1741 CreatorName Gon, Yasufumi
	NRID 1000050727451 1000050727451 ORCID 0000-0001-9147-8058 0000-0001-9147-8058 researchmap permalink y-kimura_neurol y-kimura_neurol Scopus Author ID 56673363900 56673363900 CreatorName Kimura, Yasuyoshi
	researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 NRID 1000040895398 1000040895398 ORCID 0000-0003-4668-4199 0000-0003-4668-4199 CreatorName Zha, Ling
	NRID 1000010728893 1000010728893 CreatorName Morishima, Toshitaka
	NRID 1000060183026 1000060183026 researchmap permalink read0185105 read0185105 CreatorName Ohno, Yuko
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 CreatorName Mochizuki, Hideki
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 CreatorName Sobue, Tomotaka
	NRID 1000080501824 1000080501824 CreatorName Miyashiro, Isao
Description	Hayano E., Gon Y., Kimura Y., et al. Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan. Parkinsonism and Related Disorders 119, 105966 (2024); https://doi.org/10.1016/j.parkreldis.2023.105966.
Abstract	Background: The risk of Parkinson's disease (PD)-related death in patients with cancer largely unexplored. Methods: We analyzed data from the Neoplasms ANd other causes of DEath (NANDE) study, which investigates the causes of death in patients with cancer in Japan. Standardized mortality ratios (SMRs) were calculated to compare the risk of PD-related deaths in patients with cancer to that of the general population. Poisson regression models were employed to estimate the relative risk of PD-related death in the subgroups. Results: The cohort included 548,485 patients with cancer, yielding 2,047,398 person-years at risk from 1995 to 2013. During the study period, 242,250 patients died and 145 deaths were attributable to PD. The SMR for PD-related death was 2.34 (95% confidence interval [CI]: 1.99–2.75). Patients who were diagnosed with cancer before 70 years of age had a high SMR (>5) for PD-related deaths. The SMR of patients with mouth-to-stomach cancers (lip, oral cavity, pharynx, esophagus, and stomach cancers) was 3.72 (95% CI: 2.84–4.86), while that of those with other cancers was 1.93 (95% CI: 1.57–2.37). The multivariate Poisson regression model revealed that patients with mouth-to-stomach cancers were more likely to die of PD than those without (relative risk 2.07, 95 % CI; 1.46–2.93). Conclusions: Patients with cancer are at a high risk of PD-related death; particularly, mouth-to-stomach cancers and potentially obstructing medication for PD are attributable to a high mortality risk. Careful management, including adequate PD treatment, would benefit cancer survivors with PD and reduce the risk of PD-related death.
Publisher	Elsevier Ltd
Source Title	Parkinsonism and Related Disorders
Volume (Issue)	119
Page	105966
Date of Issued	2024-02-01
Language	English
Handle URL	https://hdl.handle.net/11094/93536
PISSN	13538020
eISSN	18735126
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.parkreldis.2023.105966
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Parkinsonism and Related Disorders. 2024, 119, p. 105966
DC.title	Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan
DC.creator	Hayano, Eri
	Gon, Yasufumi
	Kimura, Yasuyoshi
	Zha, Ling
	Morishima, Toshitaka
	Ohno, Yuko
	Mochizuki, Hideki
	Sobue, Tomotaka
	Miyashiro, Isao
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-01
DC.identifier	https://doi.org/10.1016/j.parkreldis.2023.105966
DC.description	Hayano E., Gon Y., Kimura Y., et al. Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan. Parkinsonism and Related Disorders 119, 105966 (2024); https://doi.org/10.1016/j.parkreldis.2023.105966.
DCTERMS.abstract	Background: The risk of Parkinson's disease (PD)-related death in patients with cancer largely unexplored. Methods: We analyzed data from the Neoplasms ANd other causes of DEath (NANDE) study, which investigates the causes of death in patients with cancer in Japan. Standardized mortality ratios (SMRs) were calculated to compare the risk of PD-related deaths in patients with cancer to that of the general population. Poisson regression models were employed to estimate the relative risk of PD-related death in the subgroups. Results: The cohort included 548,485 patients with cancer, yielding 2,047,398 person-years at risk from 1995 to 2013. During the study period, 242,250 patients died and 145 deaths were attributable to PD. The SMR for PD-related death was 2.34 (95% confidence interval [CI]: 1.99–2.75). Patients who were diagnosed with cancer before 70 years of age had a high SMR (>5) for PD-related deaths. The SMR of patients with mouth-to-stomach cancers (lip, oral cavity, pharynx, esophagus, and stomach cancers) was 3.72 (95% CI: 2.84–4.86), while that of those with other cancers was 1.93 (95% CI: 1.57–2.37). The multivariate Poisson regression model revealed that patients with mouth-to-stomach cancers were more likely to die of PD than those without (relative risk 2.07, 95 % CI; 1.46–2.93). Conclusions: Patients with cancer are at a high risk of PD-related death; particularly, mouth-to-stomach cancers and potentially obstructing medication for PD are attributable to a high mortality risk. Careful management, including adequate PD treatment, would benefit cancer survivors with PD and reduce the risk of PD-related death.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	93536
citation_title	Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan
citation_author	Hayano, Eri
	Gon, Yasufumi
	Kimura, Yasuyoshi
	Zha, Ling
	Morishima, Toshitaka
	Ohno, Yuko
	Mochizuki, Hideki
	Sobue, Tomotaka
	Miyashiro, Isao
citation_publisher	Elsevier Ltd
citation_language	English
citation_date	2024-02-01
citation_journal_title	Parkinsonism and Related Disorders
citation_volume	119
citation_firstpage	105966
citation_doi	https://doi.org/10.1016/j.parkreldis.2023.105966
citation_public_url	https://hdl.handle.net/11094/93536

Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan

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