Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease

Maruyama, Mihoko; Tanaka, Yutaro; Momma, Koichi; Furukawa, Yoshihiro; Yoshikawa, Hiroshi Y.; Tajiri, Rie; Nakamura, Masanori; Taguchi, Kazumi; Hamamoto, Shuzo; Ando, Ryosuke; Tsukamoto, Katsuo; Takano, Kazufumi; Imanishi, Masayuki; Usami, Shigeyoshi; Kohri, Kenjiro; Okada, Atsushi; Yasui, Takahiro; Yoshimura, Masashi; Mori, Yusuke

doi:https://doi.org/10.1021/acs.cgd.3c00108

Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease

Maruyama, Mihoko; Tanaka, Yutaro; Momma, Koichi et al.

Crystal Growth and Design, 2023, 23(6), 4285-4293

Number of Access:3,067（2025-08-01 09:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94004

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Title	Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease
Creator	NRID 1000020623903 1000020623903 ORCID 0000-0002-3453-8007 0000-0002-3453-8007 researchmap permalink marumarumi marumarumi Scopus Author ID 35307485800 35307485800 CreatorName Maruyama, Mihoko
	NRID 1000070813434 1000070813434 researchmap permalink yutaro-tanaka yutaro-tanaka CreatorName Tanaka, Yutaro
	NRID 1000030552781 1000030552781 CreatorName Momma, Koichi
	NRID 1000000544107 1000000544107 CreatorName Furukawa, Yoshihiro
	NRID 1000050551173 1000050551173 ORCID 0000-0003-0624-6039 0000-0003-0624-6039 researchmap permalink read0108058 read0108058 Scopus Author ID 55708129100 55708129100 CreatorName Yoshikawa, Hiroshi Y.
	CreatorName Tajiri, Rie
	CreatorName Nakamura, Masanori
	NRID 1000000595184 1000000595184 CreatorName Taguchi, Kazumi
	NRID 1000080551267 1000080551267 CreatorName Hamamoto, Shuzo
	NRID 1000030381867 1000030381867 CreatorName Ando, Ryosuke
	NRID 1000060125614 1000060125614 CreatorName Tsukamoto, Katsuo
	NRID 1000040346185 1000040346185 CreatorName Takano, Kazufumi
	NRID 1000000795487 1000000795487 researchmap permalink Na-flux Na-flux Scopus Author ID 55361211900 55361211900 ORCID 0000-0001-9395-1750 0000-0001-9395-1750 CreatorName Imanishi, Masayuki
	NRID 1000030897947 1000030897947 researchmap permalink s_usami s_usami Scopus Author ID 56770778200 56770778200 ORCID 0000-0002-9710-1718 0000-0002-9710-1718 CreatorName Usami, Shigeyoshi
	NRID 1000030122047 1000030122047 CreatorName Kohri, Kenjiro
	NRID 1000070444966 1000070444966 CreatorName Okada, Atsushi
	NRID 1000040326153 1000040326153 CreatorName Yasui, Takahiro
	NRID 1000060314382 1000060314382 researchmap permalink read0191199 read0191199 Scopus Author ID 7403136552 7403136552 ORCID 0000-0002-0770-1251 0000-0002-0770-1251 CreatorName Yoshimura, Masashi
	NRID 1000090252618 1000090252618 ORCID 0000-0003-2952-7458 0000-0003-2952-7458 researchmap permalink mori_yusuke mori_yusuke Scopus Author ID 7404197134 7404197134 CreatorName Mori, Yusuke
Description	Maruyama M., Tanaka Y., Momma K., et al. Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease. Crystal Growth and Design 23, 4285 (2023); https://doi.org/10.1021/acs.cgd.3c00108.
Abstract	In this study, we investigated calcium oxalate (CaOx) kidney stones and showed direct evidence of the solution-mediated phase transition of calcium oxalate dihydrate (COD; the metastable phase) to calcium oxalate monohydrate (COM; the stable phase). We examined the crystal phases, crystal textures, and protein distributions within thin sections of calcium oxalate kidney stones. Observation with a polarized-light microscope showed that the outline of the mosaic texture, in which COM crystals are assembled in a mosaic pattern, roughly coincides with COD’s crystallographically stable face angles. Microfocus X-ray CT measurement captured the intermediate process of the phase transition, starting inside the COD single crystal and gradually transforming to COM crystals. In addition, the distribution of osteopontin and prothrombin fragment-1, common proteins contained in urine and visualized by multicolor fluorescence immunostaining, showed no apparent striations inside the COM single crystals with the mosaic texture, although the striation is apparent inside the COD single crystals. This is probably because the phase transition of mosaic-like COM occurred in a semiclosed system inside the COD single crystal, so the effect of periodic (day-night, seasonal, etc.) urinary protein concentration changes was small. On the other hand, striations were visible in concentrically laminated COM. This indicated that concentrically laminated COM formed in response to the changes in urinary protein concentrations. From the above, we conclude that the COD single crystals and the concentrically laminated COM seen in CaOx stones are primary structures, and the mosaic COM is a secondary structure that is a pseudomorph formed by the solution-mediated phase transition from COD single crystals.
Publisher	American Chemical Society
Source Title	Crystal Growth and Design
Volume (Issue)	23(6)
Page	4285-4293
Date of Issued	2023-06-07
Language	English
Handle URL	https://hdl.handle.net/11094/94004
PISSN	15287483
eISSN	15287505
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1021/acs.cgd.3c00108
Access Rights	open access
CopyRight	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.3c00108.
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Crystal Growth and Design. 2023, 23(6), p. 4285-4293
DC.title	Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease
DC.creator	Maruyama, Mihoko
	Tanaka, Yutaro
	Momma, Koichi
	Furukawa, Yoshihiro
	Yoshikawa, Hiroshi Y.
	Tajiri, Rie
	Nakamura, Masanori
	Taguchi, Kazumi
	Hamamoto, Shuzo
	Ando, Ryosuke
	Tsukamoto, Katsuo
	Takano, Kazufumi
	Imanishi, Masayuki
	Usami, Shigeyoshi
	Kohri, Kenjiro
	Okada, Atsushi
	Yasui, Takahiro
	Yoshimura, Masashi
	Mori, Yusuke
DC.publisher	American Chemical Society
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-06-07
DC.identifier	https://doi.org/10.1021/acs.cgd.3c00108
DC.description	Maruyama M., Tanaka Y., Momma K., et al. Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease. Crystal Growth and Design 23, 4285 (2023); https://doi.org/10.1021/acs.cgd.3c00108.
DCTERMS.abstract	In this study, we investigated calcium oxalate (CaOx) kidney stones and showed direct evidence of the solution-mediated phase transition of calcium oxalate dihydrate (COD; the metastable phase) to calcium oxalate monohydrate (COM; the stable phase). We examined the crystal phases, crystal textures, and protein distributions within thin sections of calcium oxalate kidney stones. Observation with a polarized-light microscope showed that the outline of the mosaic texture, in which COM crystals are assembled in a mosaic pattern, roughly coincides with COD’s crystallographically stable face angles. Microfocus X-ray CT measurement captured the intermediate process of the phase transition, starting inside the COD single crystal and gradually transforming to COM crystals. In addition, the distribution of osteopontin and prothrombin fragment-1, common proteins contained in urine and visualized by multicolor fluorescence immunostaining, showed no apparent striations inside the COM single crystals with the mosaic texture, although the striation is apparent inside the COD single crystals. This is probably because the phase transition of mosaic-like COM occurred in a semiclosed system inside the COD single crystal, so the effect of periodic (day-night, seasonal, etc.) urinary protein concentration changes was small. On the other hand, striations were visible in concentrically laminated COM. This indicated that concentrically laminated COM formed in response to the changes in urinary protein concentrations. From the above, we conclude that the COD single crystals and the concentrically laminated COM seen in CaOx stones are primary structures, and the mosaic COM is a secondary structure that is a pseudomorph formed by the solution-mediated phase transition from COD single crystals.
DC.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.3c00108.
DC.format	94004
citation_title	Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease
citation_author	Maruyama, Mihoko
	Tanaka, Yutaro
	Momma, Koichi
	Furukawa, Yoshihiro
	Yoshikawa, Hiroshi Y.
	Tajiri, Rie
	Nakamura, Masanori
	Taguchi, Kazumi
	Hamamoto, Shuzo
	Ando, Ryosuke
	Tsukamoto, Katsuo
	Takano, Kazufumi
	Imanishi, Masayuki
	Usami, Shigeyoshi
	Kohri, Kenjiro
	Okada, Atsushi
	Yasui, Takahiro
	Yoshimura, Masashi
	Mori, Yusuke
citation_publisher	American Chemical Society
citation_language	English
citation_date	2023-06-07
citation_journal_title	Crystal Growth and Design
citation_volume	23
citation_issue	6
citation_firstpage	4285
citation_lastpage	4293
citation_doi	https://doi.org/10.1021/acs.cgd.3c00108
citation_public_url	https://hdl.handle.net/11094/94004

Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease

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