CAD-CAM resin composites: Effective components for further development

Yamaguchi, Satoshi; Li, Hefei; Sakai, Takahiko; Lee, Chunwoo; Kitagawa, Haruaki; Imazato, Satoshi

doi:https://doi.org/10.1016/j.dental.2024.01.002

CAD-CAM resin composites: Effective components for further development

Yamaguchi, Satoshi; Li, Hefei; Sakai, Takahiko et al.

Dental Materials, 2024, 7(Suppl), 11

Number of Access:512（2025-10-22 17:52 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94595

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Title	CAD-CAM resin composites: Effective components for further development
Creator	NRID 1000030397773 1000030397773 ORCID 0000-0002-4661-8821 0000-0002-4661-8821 researchmap permalink YamaguchiS_30397773 YamaguchiS_30397773 Scopus Author ID 7403873463 7403873463 CreatorName Yamaguchi, Satoshi
	CreatorName Li, Hefei
	CreatorName Sakai, Takahiko
	CreatorName Lee, Chunwoo
	NRID 1000050736246 1000050736246 ORCID 0000-0002-5270-4865 0000-0002-5270-4865 researchmap permalink kitagawa_h kitagawa_h Scopus Author ID 55267186700 55267186700 CreatorName Kitagawa, Haruaki
	NRID 1000080243244 1000080243244 ORCID 0000-0003-3655-4809 0000-0003-3655-4809 researchmap permalink read0014210 read0014210 Scopus Author ID 55994423600 55994423600 CreatorName Imazato, Satoshi
Description	Yamaguchi Satoshi, Li Hefei, Sakai Takahiko, et al. CAD-CAM resin composites: Effective components for further development. Dental Materials 7, 11 (); https://doi.org/10.1016/j.dental.2024.01.002.
Abstract	Objective: This paper summarizes the effective components of computer-aided design and computer-aided manufacturing (CAD-CAM) resin composites that contribute to achieving greater mechanical properties and further development.Methods: In silico multi-scale analysis, in silico nonlinear dynamic finite element analysis (FEA), and artificial intelligence (AI) were used to explore the effective components of CAD-CAM resin composites. The effects of the filler diameter and silane coupling ratio on the mechanical properties of CAD-CAM resin composites have been clarified through multi-scale analysis. The effects of the filler contents, and filler and monomer compositions have been investigated by AI algorithms. The fracture behavior of CAD-CAM composite crown was analyzed using in silico non-linear dynamic FEA. The longevity of CAD-CAM composite crown was assessed through step-stress accelerating life testing (SSALT). Results: As the filler diameter decreases, there is an increase in elastic moduli and compressive strengths at the macroscale. At the nanoscale, a decrease in the filler diameter results in a decrease in the maximum value of the maximum principal strain. When the silane coupling ratio decreases, there is a decrease in the elastic modulus and compressive strength. According to the exhaustive search and feature importance analysis based on the AI algorithm, the combination ofcertain components was narrowed down to achieve a flexural strength of 269.5 MPa. The in silico non-linear FEA successfully detected the sign of the initial crack of the CAD-CAM composite molar crown. The SSALT revealed that CAD-CAM resin composite molar crowns containing nanofillers with a high fraction of resin matrix demonstrated great longevity. Significance: This paper summarized the effective components of CAD-CAM resin composites for their further development. The integration of in vitro and in silico approaches will expedite the advancement of CAD-CAM resin composites, offering benefits such as time efficiency and reduction of material waste for researchers and manufacturers.
Publisher	Elsevier BV
Source Title	Dental Materials
Volume (Issue)	7(Suppl)
Page	11
Date of Issued	2024-01-15
Language	English
Handle URL	https://hdl.handle.net/11094/94595
PISSN	01095641
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.dental.2024.01.002
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Dental Materials. 2024, 7(Suppl), p. 11
DC.title	CAD-CAM resin composites: Effective components for further development
DC.creator	Yamaguchi, Satoshi
	Li, Hefei
	Sakai, Takahiko
	Lee, Chunwoo
	Kitagawa, Haruaki
	Imazato, Satoshi
DC.publisher	Elsevier BV
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-15
DC.identifier	https://doi.org/10.1016/j.dental.2024.01.002
DC.description	Yamaguchi Satoshi, Li Hefei, Sakai Takahiko, et al. CAD-CAM resin composites: Effective components for further development. Dental Materials 7, 11 (); https://doi.org/10.1016/j.dental.2024.01.002.
DCTERMS.abstract	Objective: This paper summarizes the effective components of computer-aided design and computer-aided manufacturing (CAD-CAM) resin composites that contribute to achieving greater mechanical properties and further development.Methods: In silico multi-scale analysis, in silico nonlinear dynamic finite element analysis (FEA), and artificial intelligence (AI) were used to explore the effective components of CAD-CAM resin composites. The effects of the filler diameter and silane coupling ratio on the mechanical properties of CAD-CAM resin composites have been clarified through multi-scale analysis. The effects of the filler contents, and filler and monomer compositions have been investigated by AI algorithms. The fracture behavior of CAD-CAM composite crown was analyzed using in silico non-linear dynamic FEA. The longevity of CAD-CAM composite crown was assessed through step-stress accelerating life testing (SSALT). Results: As the filler diameter decreases, there is an increase in elastic moduli and compressive strengths at the macroscale. At the nanoscale, a decrease in the filler diameter results in a decrease in the maximum value of the maximum principal strain. When the silane coupling ratio decreases, there is a decrease in the elastic modulus and compressive strength. According to the exhaustive search and feature importance analysis based on the AI algorithm, the combination ofcertain components was narrowed down to achieve a flexural strength of 269.5 MPa. The in silico non-linear FEA successfully detected the sign of the initial crack of the CAD-CAM composite molar crown. The SSALT revealed that CAD-CAM resin composite molar crowns containing nanofillers with a high fraction of resin matrix demonstrated great longevity. Significance: This paper summarized the effective components of CAD-CAM resin composites for their further development. The integration of in vitro and in silico approaches will expedite the advancement of CAD-CAM resin composites, offering benefits such as time efficiency and reduction of material waste for researchers and manufacturers.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94595
citation_title	CAD-CAM resin composites: Effective components for further development
citation_author	Yamaguchi, Satoshi
	Li, Hefei
	Sakai, Takahiko
	Lee, Chunwoo
	Kitagawa, Haruaki
	Imazato, Satoshi
citation_publisher	Elsevier BV
citation_language	English
citation_date	2024-01-15
citation_journal_title	Dental Materials
citation_volume	7
citation_issue	Suppl
citation_firstpage	11
citation_doi	https://doi.org/10.1016/j.dental.2024.01.002
citation_public_url	https://hdl.handle.net/11094/94595

CAD-CAM resin composites: Effective components for further development

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