Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients

Ikenaka, Kensuke; Kajiyama, Yuta; Aguirre, César; Choong, Chi Jing; Taniguchi, Seira; Doi, Junko; Wang, Nan; Ajiki, Takahiro; Ogawa, Kotaro; Kakuda, Keita; Kimura, Yasuyoshi; Mochizuki, Hideki

doi:https://doi.org/10.1002/prp2.1174

Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients

Ikenaka, Kensuke; Kajiyama, Yuta; Aguirre, César et al.

Pharmacology Research and Perspectives, 2024, 12(1), e1174

Number of Access:2,031（2025-07-22 00:30 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94596

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Title	Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Creator	NRID 1000070774058 1000070774058 researchmap permalink kensukeikenaka kensukeikenaka Scopus Author ID 8588484300 8588484300 CreatorName Ikenaka, Kensuke
	NRID 1000080792390 1000080792390 ORCID 0000-0001-7170-0758 0000-0001-7170-0758 researchmap permalink ykajiyama ykajiyama CreatorName Kajiyama, Yuta
	NRID 1000020865597 1000020865597 researchmap permalink cesarderkatter cesarderkatter CreatorName Aguirre, César
	NRID 1000050796076 1000050796076 researchmap permalink choongcj choongcj CreatorName Choong, Chi Jing
	NRID 1000000894370 1000000894370 ORCID 0000-0002-5297-7716 0000-0002-5297-7716 researchmap permalink seirataniguchi seirataniguchi Scopus Author ID 57336847600 57336847600 CreatorName Taniguchi, Seira
	NRID 1000050343728 1000050343728 researchmap permalink read0070576 read0070576 CreatorName Doi, Junko
	CreatorName Wang, Nan
	CreatorName Ajiki, Takahiro
	NRID 1000080870500 1000080870500 researchmap permalink jihdiegisojosugudc jihdiegisojosugudc Scopus Author ID 57200553653 57200553653 CreatorName Ogawa, Kotaro
	NRID 1000020815500 1000020815500 researchmap permalink keitakakuda keitakakuda Scopus Author ID 57192154985 57192154985 CreatorName Kakuda, Keita
	NRID 1000050727451 1000050727451 ORCID 0000-0001-9147-8058 0000-0001-9147-8058 researchmap permalink y-kimura_neurol y-kimura_neurol Scopus Author ID 56673363900 56673363900 CreatorName Kimura, Yasuyoshi
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 CreatorName Mochizuki, Hideki
Subject	biomarker
	COMT inhibitor
	Levodopa-Carbidopa Intestinal Gel Infusion
	Opicapone
	Parkinson's disease
	vitamin B6
Description	Ikenaka K., Kajiyama Y., Aguirre C., et al. Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients. Pharmacology Research and Perspectives 12, e1174 (2024); https://doi.org/10.1002/prp2.1174.
Abstract	The study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa–Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD, n = 72 and controls, n = 31). The vitamin B6 level was compared with the total levodopa dose, clinical parameters, and blood homocysteine, albumin, and hemoglobin levels in PD patients. Correlations between vitamin B6 levels and AST and ALT levels, as well as the ratio ALT/AST, were analyzed. Changes in the AST and ALT levels and ALT/AST were analyzed in the patients treated with LCIG before and after the therapy (n = 24) and in the patients treated with LCIG + Opicapone before and after Opicapone treatment (n = 12). We found vitamin B6 levels were significantly lower in PD patients. Total levodopa dose and albumin levels were independently associated with vitamin B6 levels. Decreased vitamin B6 levels appeared as lower AST and ALT levels and ALT/AS. Treatment with LCIG decreased the AST and ALT levels and ALT/AST. Adjunctive therapy with Opicapone to LCIG ameliorated the decreased ALT and ALT/AST. We conclude that the ALT and ALT/AST can be useful parameters for monitoring vitamin B6 levels and Opicapone can ameliorate the dysregulated vitamin B6 in PD patients.
Publisher	John Wiley and Sons Inc
Source Title	Pharmacology Research and Perspectives
Volume (Issue)	12(1)
Page	e1174
Date of Issued	2024-02-01
Language	English
Handle URL	https://hdl.handle.net/11094/94596
eISSN	20521707
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/prp2.1174
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Pharmacology Research and Perspectives. 2024, 12(1), p. e1174
DC.title	Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
DC.creator	Ikenaka, Kensuke
	Kajiyama, Yuta
	Aguirre, César
	Choong, Chi Jing
	Taniguchi, Seira
	Doi, Junko
	Wang, Nan
	Ajiki, Takahiro
	Ogawa, Kotaro
	Kakuda, Keita
	Kimura, Yasuyoshi
	Mochizuki, Hideki
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-01
DC.identifier	https://doi.org/10.1002/prp2.1174
DC.subject	biomarker
	COMT inhibitor
	Levodopa-Carbidopa Intestinal Gel Infusion
	Opicapone
	Parkinson's disease
	vitamin B6
DC.description	Ikenaka K., Kajiyama Y., Aguirre C., et al. Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients. Pharmacology Research and Perspectives 12, e1174 (2024); https://doi.org/10.1002/prp2.1174.
DCTERMS.abstract	The study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa–Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD, n = 72 and controls, n = 31). The vitamin B6 level was compared with the total levodopa dose, clinical parameters, and blood homocysteine, albumin, and hemoglobin levels in PD patients. Correlations between vitamin B6 levels and AST and ALT levels, as well as the ratio ALT/AST, were analyzed. Changes in the AST and ALT levels and ALT/AST were analyzed in the patients treated with LCIG before and after the therapy (n = 24) and in the patients treated with LCIG + Opicapone before and after Opicapone treatment (n = 12). We found vitamin B6 levels were significantly lower in PD patients. Total levodopa dose and albumin levels were independently associated with vitamin B6 levels. Decreased vitamin B6 levels appeared as lower AST and ALT levels and ALT/AS. Treatment with LCIG decreased the AST and ALT levels and ALT/AST. Adjunctive therapy with Opicapone to LCIG ameliorated the decreased ALT and ALT/AST. We conclude that the ALT and ALT/AST can be useful parameters for monitoring vitamin B6 levels and Opicapone can ameliorate the dysregulated vitamin B6 in PD patients.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	94596
citation_title	Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
citation_author	Ikenaka, Kensuke
	Kajiyama, Yuta
	Aguirre, César
	Choong, Chi Jing
	Taniguchi, Seira
	Doi, Junko
	Wang, Nan
	Ajiki, Takahiro
	Ogawa, Kotaro
	Kakuda, Keita
	Kimura, Yasuyoshi
	Mochizuki, Hideki
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-02-01
citation_journal_title	Pharmacology Research and Perspectives
citation_volume	12
citation_issue	1
citation_firstpage	e1174
citation_doi	https://doi.org/10.1002/prp2.1174
citation_public_url	https://hdl.handle.net/11094/94596

Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients

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