Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone

Wang, Jun; Ishimoto, Takuya; Matsuzaka, Tadaaki; Matsugaki, Aira; Ozasa, Ryosuke; Matsumoto, Takuya; Hayashi, Mikako; Kim, Hyoung Seop; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.bone.2024.117024

Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone

Wang, Jun; Ishimoto, Takuya; Matsuzaka, Tadaaki et al.

Bone, 2024, 181, 117024

Number of Access:535（2025-07-18 09:52 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94601

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Title	Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone
Creator	CreatorName Wang, Jun
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 CreatorName Ishimoto, Takuya
	CreatorName Matsuzaka, Tadaaki
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 CreatorName Matsugaki, Aira
	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 CreatorName Ozasa, Ryosuke
	NRID 1000040324793 1000040324793 CreatorName Matsumoto, Takuya
	NRID 1000040271027 1000040271027 researchmap permalink read0185244 read0185244 Scopus Author ID 26021225700 26021225700 CreatorName Hayashi, Mikako
	CreatorName Kim, Hyoung Seop
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 CreatorName Nakano, Takayoshi
Subject	Apatite orientation
	Bone quality
	Bone strength
	Functional adaptation
	In vivo loading
Description	Wang J., Ishimoto T., Matsuzaka T., et al. Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone. Bone 181, 117024 (2024); https://doi.org/10.1016/j.bone.2024.117024.
Abstract	Functional adaptation refers to the active modification of bone structure according to the mechanical loads applied daily to maintain its mechanical integrity and adapt to the environment. Functional adaptation relates to bone mass, bone mineral density (BMD), and bone morphology (e.g., trabecular bone architecture). In this study, we discovered for the first time that another form of bone functional adaptation of a cortical bone involves a change in bone quality determined by the preferential orientation of apatite nano-crystallite, a key component of the bone. An in vivo rat ulnar axial loading model was adopted, to which a 3–15 N compressive load was applied, resulting in approximately 440–3200 μɛ of compression in the bone surface. In the loaded ulnae, the degree of preferential apatite c-axis orientation along the ulnar long axis increased in a dose-dependent manner up to 13 N, whereas the increase in BMD was not dose-dependent. The Young's modulus along the same direction was enhanced as a function of the degree of apatite orientation. This finding indicates that bone has a mechanism that modifies the directionality (anisotropy) of its microstructure, strengthening itself specifically in the loaded direction. BMD, a scalar quantity, does not allow for load-direction-specific strengthening. Functional adaptation through changes in apatite orientation is an excellent strategy for bones to efficiently change their strength in response to external loading, which is mostly anisotropic.
Publisher	Elsevier Inc.
Source Title	Bone
Volume (Issue)	181
Page	117024
Date of Issued	2024-04-01
Language	English
Handle URL	https://hdl.handle.net/11094/94601
PISSN	87563282
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bone.2024.117024
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Bone. 2024, 181, p. 117024
DC.title	Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone
DC.creator	Wang, Jun
	Ishimoto, Takuya
	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Ozasa, Ryosuke
	Matsumoto, Takuya
	Hayashi, Mikako
	Kim, Hyoung Seop
	Nakano, Takayoshi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-01
DC.identifier	https://doi.org/10.1016/j.bone.2024.117024
DC.subject	Apatite orientation
	Bone quality
	Bone strength
	Functional adaptation
	In vivo loading
DC.description	Wang J., Ishimoto T., Matsuzaka T., et al. Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone. Bone 181, 117024 (2024); https://doi.org/10.1016/j.bone.2024.117024.
DCTERMS.abstract	Functional adaptation refers to the active modification of bone structure according to the mechanical loads applied daily to maintain its mechanical integrity and adapt to the environment. Functional adaptation relates to bone mass, bone mineral density (BMD), and bone morphology (e.g., trabecular bone architecture). In this study, we discovered for the first time that another form of bone functional adaptation of a cortical bone involves a change in bone quality determined by the preferential orientation of apatite nano-crystallite, a key component of the bone. An in vivo rat ulnar axial loading model was adopted, to which a 3–15 N compressive load was applied, resulting in approximately 440–3200 μɛ of compression in the bone surface. In the loaded ulnae, the degree of preferential apatite c-axis orientation along the ulnar long axis increased in a dose-dependent manner up to 13 N, whereas the increase in BMD was not dose-dependent. The Young's modulus along the same direction was enhanced as a function of the degree of apatite orientation. This finding indicates that bone has a mechanism that modifies the directionality (anisotropy) of its microstructure, strengthening itself specifically in the loaded direction. BMD, a scalar quantity, does not allow for load-direction-specific strengthening. Functional adaptation through changes in apatite orientation is an excellent strategy for bones to efficiently change their strength in response to external loading, which is mostly anisotropic.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94601
citation_title	Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone
citation_author	Wang, Jun
	Ishimoto, Takuya
	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Ozasa, Ryosuke
	Matsumoto, Takuya
	Hayashi, Mikako
	Kim, Hyoung Seop
	Nakano, Takayoshi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2024-04-01
citation_journal_title	Bone
citation_volume	181
citation_firstpage	117024
citation_doi	https://doi.org/10.1016/j.bone.2024.117024
citation_public_url	https://hdl.handle.net/11094/94601

Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone

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