(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Yokoyama, Rei; Ago, Yukio; Igarashi, Hisato; Higuchi, Momoko; Tanuma, Masato; Shimazaki, Yuto; Kawai, Takafumi; Seiriki, Kaoru; Hayashida, Misuzu; Yamaguchi, Shun; Tanaka, Hirokazu; Nakazawa, Takanobu; Okamura, Yasushi; Hashimoto, Kenji; Kasai, Atsushi; Hashimoto, Hitoshi

doi:https://doi.org/10.1038/s41380-024-02419-6

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Yokoyama, Rei; Ago, Yukio; Igarashi, Hisato et al.

Molecular Psychiatry, 2024, 29, 1406-1416

Number of Access:57（2025-05-02 13:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94697

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Title	(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice
Creator	CreatorName Yokoyama, Rei
	NRID 1000050403027 1000050403027 CreatorName Ago, Yukio
	CreatorName Igarashi, Hisato
	CreatorName Higuchi, Momoko
	CreatorName Tanuma, Masato
	CreatorName Shimazaki, Yuto
	NRID 1000070614915 1000070614915 researchmap permalink t_kawa t_kawa Scopus Author ID 55465095900 55465095900 CreatorName Kawai, Takafumi
	NRID 1000090802918 1000090802918 researchmap permalink kaoru-seiriki kaoru-seiriki Scopus Author ID 55318807200 55318807200 CreatorName Seiriki, Kaoru
	CreatorName Hayashida, Misuzu
	NRID 1000070304087 1000070304087 CreatorName Yamaguchi, Shun
	NRID 1000000332320 1000000332320 CreatorName Tanaka, Hirokazu
	NRID 1000000447335 1000000447335 CreatorName Nakazawa, Takanobu
	NRID 1000080201987 1000080201987 researchmap permalink yasushiokamura yasushiokamura Scopus Author ID 55322083200 55322083200 ORCID 0000-0001-5386-7968 0000-0001-5386-7968 CreatorName Okamura, Yasushi
	NRID 1000010189483 1000010189483 CreatorName Hashimoto, Kenji
	NRID 1000040454649 1000040454649 ORCID 0000-0002-1612-3078 0000-0002-1612-3078 researchmap permalink read0136710 read0136710 Scopus Author ID 36543827900 36543827900 CreatorName Kasai, Atsushi
	NRID 1000030240849 1000030240849 researchmap permalink hitoshi-hashimoto hitoshi-hashimoto Scopus Author ID 35352982100 35352982100 ORCID 0000-0001-6548-4016 0000-0001-6548-4016 CreatorName Hashimoto, Hitoshi
Description	Yokoyama R., Ago Y., Igarashi H., et al. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular Psychiatry , (2024); https://doi.org/10.1038/s41380-024-02419-6.
Abstract	Chronic social isolation increases the risk of mental health problems, including cognitive impairments and depression. While subanesthetic ketamine is considered effective for cognitive impairments in patients with depression, the neural mechanisms underlying its effects are not well understood. Here we identified unique activation of the anterior insular cortex (aIC) as a characteristic feature in brain-wide regions of mice reared in social isolation and treated with (R)-ketamine, a ketamine enantiomer. Using fiber photometry recording on freely moving mice, we found that social isolation attenuates aIC neuronal activation upon social contact and that (R)-ketamine, but not (S)-ketamine, is able to counteracts this reduction. (R)-ketamine facilitated social cognition in social isolation-reared mice during the social memory test. aIC inactivation offset the effect of (R)-ketamine on social memory. Our results suggest that (R)-ketamine has promising potential as an effective intervention for social cognitive deficits by restoring aIC function.
Publisher	Springer Nature
Source Title	Molecular Psychiatry
Volume (Issue)	29
Page	1406-1416
Date of Issued	2024-02-23
Language	English
Handle URL	https://hdl.handle.net/11094/94697
PISSN	13594184
eISSN	14765578
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41380-024-02419-6
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Molecular Psychiatry. 2024, 29, p. 1406-1416
DC.title	(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice
DC.creator	Yokoyama, Rei
	Ago, Yukio
	Igarashi, Hisato
	Higuchi, Momoko
	Tanuma, Masato
	Shimazaki, Yuto
	Kawai, Takafumi
	Seiriki, Kaoru
	Hayashida, Misuzu
	Yamaguchi, Shun
	Tanaka, Hirokazu
	Nakazawa, Takanobu
	Okamura, Yasushi
	Hashimoto, Kenji
	Kasai, Atsushi
	Hashimoto, Hitoshi
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-23
DC.identifier	https://doi.org/10.1038/s41380-024-02419-6
DC.description	Yokoyama R., Ago Y., Igarashi H., et al. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. Molecular Psychiatry , (2024); https://doi.org/10.1038/s41380-024-02419-6.
DCTERMS.abstract	Chronic social isolation increases the risk of mental health problems, including cognitive impairments and depression. While subanesthetic ketamine is considered effective for cognitive impairments in patients with depression, the neural mechanisms underlying its effects are not well understood. Here we identified unique activation of the anterior insular cortex (aIC) as a characteristic feature in brain-wide regions of mice reared in social isolation and treated with (R)-ketamine, a ketamine enantiomer. Using fiber photometry recording on freely moving mice, we found that social isolation attenuates aIC neuronal activation upon social contact and that (R)-ketamine, but not (S)-ketamine, is able to counteracts this reduction. (R)-ketamine facilitated social cognition in social isolation-reared mice during the social memory test. aIC inactivation offset the effect of (R)-ketamine on social memory. Our results suggest that (R)-ketamine has promising potential as an effective intervention for social cognitive deficits by restoring aIC function.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94697
citation_title	(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice
citation_author	Yokoyama, Rei
	Ago, Yukio
	Igarashi, Hisato
	Higuchi, Momoko
	Tanuma, Masato
	Shimazaki, Yuto
	Kawai, Takafumi
	Seiriki, Kaoru
	Hayashida, Misuzu
	Yamaguchi, Shun
	Tanaka, Hirokazu
	Nakazawa, Takanobu
	Okamura, Yasushi
	Hashimoto, Kenji
	Kasai, Atsushi
	Hashimoto, Hitoshi
citation_publisher	Springer Nature
citation_language	English
citation_date	2024-02-23
citation_journal_title	Molecular Psychiatry
citation_volume	29
citation_firstpage	1406
citation_lastpage	1416
citation_doi	https://doi.org/10.1038/s41380-024-02419-6
citation_public_url	https://hdl.handle.net/11094/94697

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

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