Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

Fujii, Kohei; Fujishima, Yuya; Kita, Shunbun; Kawada, Keitaro; Fukuoka, Keita; Sakaue, Taka Aki; Okita, Tomonori; Kawada-Horitani, Emi; Nagao, Hirofumi; Fukuda, Shiro; Maeda, Norikazu; Nishizawa, Hitoshi; Shimomura, Iichiro

doi:https://doi.org/10.1038/s41598-024-51935-6

Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

Fujii, Kohei; Fujishima, Yuya; Kita, Shunbun et al.

Scientific Reports, 2024, 14(1), 3620

Number of Access:1,399（2025-07-18 09:51 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94892

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Title	Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
Creator	CreatorName Fujii, Kohei
	NRID 1000010779789 1000010779789 researchmap permalink Yuya_Fujishima Yuya_Fujishima Scopus Author ID 54410318600 54410318600 CreatorName Fujishima, Yuya
	NRID 1000010746572 1000010746572 CreatorName Kita, Shunbun
	CreatorName Kawada, Keitaro
	CreatorName Fukuoka, Keita
	CreatorName Sakaue, Taka Aki
	CreatorName Okita, Tomonori
	CreatorName Kawada-Horitani, Emi
	NRID 1000070983146 1000070983146 researchmap permalink Hirofumi_Nagao Hirofumi_Nagao ORCID 0009-0001-1261-4160 0009-0001-1261-4160 CreatorName Nagao, Hirofumi
	NRID 1000000896467 1000000896467 researchmap permalink sfukuda-ou sfukuda-ou Scopus Author ID 55766129200 55766129200 CreatorName Fukuda, Shiro
	NRID 1000030506308 1000030506308 researchmap permalink Adiponectin Adiponectin Scopus Author ID 7401561691 7401561691 CreatorName Maeda, Norikazu
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
Description	Fujii K., Fujishima Y., Kita S., et al. Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin. Scientific Reports 14, 3620 (2024); https://doi.org/10.1038/s41598-024-51935-6.
Abstract	Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14(1)
Page	3620
Date of Issued	2024-02-13
Language	English
Handle URL	https://hdl.handle.net/11094/94892
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-51935-6
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14(1), p. 3620
DC.title	Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
DC.creator	Fujii, Kohei
	Fujishima, Yuya
	Kita, Shunbun
	Kawada, Keitaro
	Fukuoka, Keita
	Sakaue, Taka Aki
	Okita, Tomonori
	Kawada-Horitani, Emi
	Nagao, Hirofumi
	Fukuda, Shiro
	Maeda, Norikazu
	Nishizawa, Hitoshi
	Shimomura, Iichiro
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-02-13
DC.identifier	https://doi.org/10.1038/s41598-024-51935-6
DC.description	Fujii K., Fujishima Y., Kita S., et al. Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin. Scientific Reports 14, 3620 (2024); https://doi.org/10.1038/s41598-024-51935-6.
DCTERMS.abstract	Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94892
citation_title	Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
citation_author	Fujii, Kohei
	Fujishima, Yuya
	Kita, Shunbun
	Kawada, Keitaro
	Fukuoka, Keita
	Sakaue, Taka Aki
	Okita, Tomonori
	Kawada-Horitani, Emi
	Nagao, Hirofumi
	Fukuda, Shiro
	Maeda, Norikazu
	Nishizawa, Hitoshi
	Shimomura, Iichiro
citation_publisher	Nature Research
citation_language	English
citation_date	2024-02-13
citation_journal_title	Scientific Reports
citation_volume	14
citation_issue	1
citation_firstpage	3620
citation_doi	https://doi.org/10.1038/s41598-024-51935-6
citation_public_url	https://hdl.handle.net/11094/94892

Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

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