Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

Kubota, Hiroshi; Fukushima, Yoko; Kawasaki, Ryo; Endo, Takao; Hatsukawa, Yoshikazu; Ineyama, Hiromi; Hirata, Katsuya; Hirano, Shinya; Wada, Kazuko; Nishida, Kohji

doi:https://doi.org/10.1136/bjo-2023-324225

Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

Kubota, Hiroshi; Fukushima, Yoko; Kawasaki, Ryo et al.

British Journal of Ophthalmology, 2024, 108(9), bjo-2023-324225

Number of Access:841（2025-08-15 10:58 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94896

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Title	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
Creator	CreatorName Kubota, Hiroshi
	NRID 1000070647031 1000070647031 ORCID 0000-0001-7909-7332 0000-0001-7909-7332 researchmap permalink Fukushima_0812 Fukushima_0812 Scopus Author ID 8316367400 8316367400 CreatorName Fukushima, Yoko
	NRID 1000070301067 1000070301067 ORCID 0000-0002-7492-6303 0000-0002-7492-6303 researchmap permalink ryok ryok Scopus Author ID 35229910100 35229910100 CreatorName Kawasaki, Ryo
	CreatorName Endo, Takao
	CreatorName Hatsukawa, Yoshikazu
	CreatorName Ineyama, Hiromi
	NRID 1000030724306 1000030724306 CreatorName Hirata, Katsuya
	CreatorName Hirano, Shinya
	CreatorName Wada, Kazuko
	NRID 1000040244610 1000040244610 ORCID 0000-0001-9069-3610 0000-0001-9069-3610 researchmap permalink read0131487 read0131487 Scopus Author ID 57211973404 57211973404 CreatorName Nishida, Kohji
Description	Kubota H., Fukushima Y., Kawasaki R., et al. Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort. British Journal of Ophthalmology , bjo-2023-324225 (2024); https://doi.org/10.1136/bjo-2023-324225.
Abstract	Background/aims : We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods : This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital in Japan. We extracted data on birth weight (BW), birth length, gestational age (GA) and minute-by-minute SpO2 during the first 20 days from the medical records. We defined four SpO2 variables using sequential measurements. Multivariate logistic regression was used to develop a model that combined birth data and SpO2 data to predict treatment-requiring ROP (TR-ROP). The model’s performance was evaluated using the area under the receiver operating characteristic curve (AUC). Results : Among 350 infants, 83 (23.7%) required ROP treatment. The SpO2 variables in infants with TR-ROP differed significantly from those with non-TR-ROP. The average SpO2 and high SpO2 showed strong associations with GA (r=0.73 and r=0.70, respectively). The model incorporating birth data and the four SpO2 variables demonstrated good discriminative ability (AUC=0.83), but it did not outperform the model incorporating BW and GA (AUC=0.82). Conclusion Data obtained by continuous SpO2 monitoring demonstrated valuable associations with severe ROP, as well as with GA. Differences in the distribution of average SpO2 and high SpO2 between infants with TR-ROP and non-TR-ROP could be used to establish efficient cut-off values for risk determination.
Publisher	BMJ Publishing Group
Source Title	British Journal of Ophthalmology
Volume (Issue)	108(9)
Page	bjo-2023-324225
Date of Issued	2024-03-06
Language	English
Handle URL	https://hdl.handle.net/11094/94896
PISSN	00071161
eISSN	14682079
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1136/bjo-2023-324225
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	British Journal of Ophthalmology. 2024, 108(9), p. bjo-2023-324225
DC.title	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
DC.creator	Kubota, Hiroshi
	Fukushima, Yoko
	Kawasaki, Ryo
	Endo, Takao
	Hatsukawa, Yoshikazu
	Ineyama, Hiromi
	Hirata, Katsuya
	Hirano, Shinya
	Wada, Kazuko
	Nishida, Kohji
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-03-06
DC.identifier	https://doi.org/10.1136/bjo-2023-324225
DC.description	Kubota H., Fukushima Y., Kawasaki R., et al. Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort. British Journal of Ophthalmology , bjo-2023-324225 (2024); https://doi.org/10.1136/bjo-2023-324225.
DCTERMS.abstract	Background/aims : We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods : This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital in Japan. We extracted data on birth weight (BW), birth length, gestational age (GA) and minute-by-minute SpO2 during the first 20 days from the medical records. We defined four SpO2 variables using sequential measurements. Multivariate logistic regression was used to develop a model that combined birth data and SpO2 data to predict treatment-requiring ROP (TR-ROP). The model’s performance was evaluated using the area under the receiver operating characteristic curve (AUC). Results : Among 350 infants, 83 (23.7%) required ROP treatment. The SpO2 variables in infants with TR-ROP differed significantly from those with non-TR-ROP. The average SpO2 and high SpO2 showed strong associations with GA (r=0.73 and r=0.70, respectively). The model incorporating birth data and the four SpO2 variables demonstrated good discriminative ability (AUC=0.83), but it did not outperform the model incorporating BW and GA (AUC=0.82). Conclusion Data obtained by continuous SpO2 monitoring demonstrated valuable associations with severe ROP, as well as with GA. Differences in the distribution of average SpO2 and high SpO2 between infants with TR-ROP and non-TR-ROP could be used to establish efficient cut-off values for risk determination.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	94896
citation_title	Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort
citation_author	Kubota, Hiroshi
	Fukushima, Yoko
	Kawasaki, Ryo
	Endo, Takao
	Hatsukawa, Yoshikazu
	Ineyama, Hiromi
	Hirata, Katsuya
	Hirano, Shinya
	Wada, Kazuko
	Nishida, Kohji
citation_publisher	BMJ Publishing Group
citation_language	English
citation_date	2024-03-06
citation_journal_title	British Journal of Ophthalmology
citation_volume	108
citation_issue	9
citation_firstpage	bjo-2023-324225
citation_doi	https://doi.org/10.1136/bjo-2023-324225
citation_public_url	https://hdl.handle.net/11094/94896

Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort

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