Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

Fukushima, Kentaro; Kudo, Hayami; Oka, Kentaro; Hayashi, Atsushi; Onizuka, Makoto; Kusakabe, Shinsuke; Hino, Akihisa; Takahashi, Motomichi; Takeda, Kiyoshi; Mori, Masaki; Ando, Kiyoshi; Hosen, Naoki

doi:https://doi.org/10.1038/s41409-024-02250-1

Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

Fukushima, Kentaro; Kudo, Hayami; Oka, Kentaro et al.

Bone Marrow Transplantation, 2024, 59, 795-802

Number of Access:1,629（2025-09-10 00:10 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95019

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Title	Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation
Creator	NRID 1000070546879 1000070546879 researchmap permalink 0668795111 0668795111 Scopus Author ID 55295454200 55295454200 CreatorName Fukushima, Kentaro
	CreatorName Kudo, Hayami
	CreatorName Oka, Kentaro
	CreatorName Hayashi, Atsushi
	NRID 1000080366012 1000080366012 CreatorName Onizuka, Makoto
	NRID 1000050747186 1000050747186 researchmap permalink kskbsnsk kskbsnsk Scopus Author ID 54585439300 54585439300 CreatorName Kusakabe, Shinsuke
	CreatorName Hino, Akihisa
	CreatorName Takahashi, Motomichi
	NRID 1000020309446 1000020309446 ORCID 0000-0002-1778-6332 0000-0002-1778-6332 researchmap permalink read0118278 read0118278 Scopus Author ID 7404335442 7404335442 CreatorName Takeda, Kiyoshi
	NRID 1000070190999 1000070190999 CreatorName Mori, Masaki
	NRID 1000070176014 1000070176014 CreatorName Ando, Kiyoshi
	NRID 1000010456923 1000010456923 researchmap permalink hnaoki hnaoki Scopus Author ID 55928728700 55928728700 ORCID 0000-0001-9570-0947 0000-0001-9570-0947 CreatorName Hosen, Naoki
Description	Fukushima K., Kudo H., Oka K., et al. Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation. Bone Marrow Transplantation , (2024); https://doi.org/10.1038/s41409-024-02250-1.
Abstract	In patients undergoing haematopoietic stem-cell transplantation (HSCT), the intestinal microbiota plays an important role in prognosis, transplant outcome, and complications such as graft-versus-host disease (GVHD). Our prior research revealed that patients undergoing HSCT substantially differed from healthy controls. In this retrospective study, we showed that administering Clostridium butyricum MIYAIRI 588 (CBM588) as a live biotherapeutic agent is associated with maintaining intestinal microbiota in the early post-HSCT period. Alpha diversity, which reflects species richness, declined considerably in patients who did not receive CBM588, whereas it remained consistent in those who received CBM588. In addition, β-diversity analysis revealed that CBM588 did not alter the gut microbiota structure at 7–21 days post-HSCT. Patients who developed GVHD showed structural changes in their microbiota from the pre-transplant period, which was noticeable on day 14 before developing GVHD. Enterococcus was significantly prevalent in patients with GVHD after HSCT, and the population of Bacteroides was maintained from the pre-HSCT period through to the post-HSCT period. Patients who received CBM588 exhibited a contrasting trend, with lower relative abundances of both genera Enterococcus and Bacteroides. These results suggest that preoperative treatment with CBM588 could potentially be beneficial in maintaining intestinal microbiota balance.
Publisher	Springer Nature
Source Title	Bone Marrow Transplantation
Volume (Issue)	59
Page	795-802
Date of Issued	2024-03-02
Language	English
Handle URL	https://hdl.handle.net/11094/95019
PISSN	02683369
eISSN	14765365
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41409-024-02250-1
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Bone Marrow Transplantation. 2024, 59, p. 795-802
DC.title	Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation
DC.creator	Fukushima, Kentaro
	Kudo, Hayami
	Oka, Kentaro
	Hayashi, Atsushi
	Onizuka, Makoto
	Kusakabe, Shinsuke
	Hino, Akihisa
	Takahashi, Motomichi
	Takeda, Kiyoshi
	Mori, Masaki
	Ando, Kiyoshi
	Hosen, Naoki
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-03-02
DC.identifier	https://doi.org/10.1038/s41409-024-02250-1
DC.description	Fukushima K., Kudo H., Oka K., et al. Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation. Bone Marrow Transplantation , (2024); https://doi.org/10.1038/s41409-024-02250-1.
DCTERMS.abstract	In patients undergoing haematopoietic stem-cell transplantation (HSCT), the intestinal microbiota plays an important role in prognosis, transplant outcome, and complications such as graft-versus-host disease (GVHD). Our prior research revealed that patients undergoing HSCT substantially differed from healthy controls. In this retrospective study, we showed that administering Clostridium butyricum MIYAIRI 588 (CBM588) as a live biotherapeutic agent is associated with maintaining intestinal microbiota in the early post-HSCT period. Alpha diversity, which reflects species richness, declined considerably in patients who did not receive CBM588, whereas it remained consistent in those who received CBM588. In addition, β-diversity analysis revealed that CBM588 did not alter the gut microbiota structure at 7–21 days post-HSCT. Patients who developed GVHD showed structural changes in their microbiota from the pre-transplant period, which was noticeable on day 14 before developing GVHD. Enterococcus was significantly prevalent in patients with GVHD after HSCT, and the population of Bacteroides was maintained from the pre-HSCT period through to the post-HSCT period. Patients who received CBM588 exhibited a contrasting trend, with lower relative abundances of both genera Enterococcus and Bacteroides. These results suggest that preoperative treatment with CBM588 could potentially be beneficial in maintaining intestinal microbiota balance.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	95019
citation_title	Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation
citation_author	Fukushima, Kentaro
	Kudo, Hayami
	Oka, Kentaro
	Hayashi, Atsushi
	Onizuka, Makoto
	Kusakabe, Shinsuke
	Hino, Akihisa
	Takahashi, Motomichi
	Takeda, Kiyoshi
	Mori, Masaki
	Ando, Kiyoshi
	Hosen, Naoki
citation_publisher	Springer Nature
citation_language	English
citation_date	2024-03-02
citation_journal_title	Bone Marrow Transplantation
citation_volume	59
citation_firstpage	795
citation_lastpage	802
citation_doi	https://doi.org/10.1038/s41409-024-02250-1
citation_public_url	https://hdl.handle.net/11094/95019

Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

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