Phase-amplitude coupling of ripple activities during seizure evolution with theta phase

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi; Tani, Naoki; Oshino, Satoru; Kishima, Haruhiko; Hirata, Masayuki

doi:https://doi.org/10.1016/j.clinph.2021.03.007

Phase-amplitude coupling of ripple activities during seizure evolution with theta phase

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi et al.

Clinical Neurophysiology, 2021, 132(6), 1243-1253

Number of Access:1,438（2025-10-20 16:58 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95539

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Title	Phase-amplitude coupling of ripple activities during seizure evolution with theta phase
Creator	NRID 1000050770674 1000050770674 ORCID 0000-0003-4057-4466 0000-0003-4057-4466 researchmap permalink yousyou0720 yousyou0720 Scopus Author ID 56922570200 56922570200 CreatorName Hashimoto, Hiroaki
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 CreatorName Khoo, Hui Ming
	NRID 1000090533802 1000090533802 researchmap permalink takufumi takufumi Scopus Author ID 16553812400 16553812400 ORCID 0000-0002-2057-0612 0000-0002-2057-0612 CreatorName Yanagisawa, Takufumi
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 CreatorName Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
	NRID 1000030372626 1000030372626 researchmap permalink hiratty hiratty Scopus Author ID 7403352253 7403352253 CreatorName Hirata, Masayuki
Subject	High-frequency activities
	Intracranial EEG
	Phase-amplitude coupling
	Seizures
	Theta band
	Visualization
Description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Phase-amplitude coupling of ripple activities during seizure evolution with theta phase. Clinical Neurophysiology 132, 1243 (2021); https://doi.org/10.1016/j.clinph.2021.03.007.
Abstract	Objective: High-frequency activities (HFAs) and phase-amplitude coupling (PAC) are key neurophysiological biomarkers for studying human epilepsy. We aimed to clarify and visualize how HFAs are modulated by the phase of low-frequency bands during seizures. Methods: We used intracranial electrodes to record seizures of focal epilepsy (12 focal-to-bilateral tonic-clonic seizures and three focal-aware seizures in seven patients). The synchronization index, representing PAC, was used to analyze the coupling between the amplitude of ripples (80–250 Hz) and the phase of lower frequencies. We created a video in which the intracranial electrode contacts were scaled linearly to the power changes of ripple. Results: The main low frequency band modulating ictal-ripple activities was the θ band (4–8 Hz), and after completion of ictal-ripple burst, δ (1–4 Hz)-ripple PAC occurred. The ripple power increased simultaneously with rhythmic fluctuations from the seizure onset zone, and spread to other regions. Conclusions: Ripple activities during seizure evolution were modulated by the θ phase. The PAC phenomenon was visualized as rhythmic fluctuations. Significance: Ripple power associated with seizure evolution increased and spread with fluctuations. The θ oscillations related to the fluctuations might represent the common neurophysiological processing involved in seizure generation.
Publisher	Elsevier Ireland Ltd
Source Title	Clinical Neurophysiology
Volume (Issue)	132(6)
Page	1243-1253
Date of Issued	2021-06-01
Language	English
Handle URL	https://hdl.handle.net/11094/95539
PISSN	13882457
eISSN	18728952
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/j.clinph.2021.03.007
Access Rights	open access
CopyRight	©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Clinical Neurophysiology. 2021, 132(6), p. 1243-1253
DC.title	Phase-amplitude coupling of ripple activities during seizure evolution with theta phase
DC.creator	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Kishima, Haruhiko
	Hirata, Masayuki
DC.publisher	Elsevier Ireland Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-06-01
DC.identifier	https://doi.org/10.1016/j.clinph.2021.03.007
DC.subject	High-frequency activities
	Intracranial EEG
	Phase-amplitude coupling
	Seizures
	Theta band
	Visualization
DC.description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Phase-amplitude coupling of ripple activities during seizure evolution with theta phase. Clinical Neurophysiology 132, 1243 (2021); https://doi.org/10.1016/j.clinph.2021.03.007.
DCTERMS.abstract	Objective: High-frequency activities (HFAs) and phase-amplitude coupling (PAC) are key neurophysiological biomarkers for studying human epilepsy. We aimed to clarify and visualize how HFAs are modulated by the phase of low-frequency bands during seizures. Methods: We used intracranial electrodes to record seizures of focal epilepsy (12 focal-to-bilateral tonic-clonic seizures and three focal-aware seizures in seven patients). The synchronization index, representing PAC, was used to analyze the coupling between the amplitude of ripples (80–250 Hz) and the phase of lower frequencies. We created a video in which the intracranial electrode contacts were scaled linearly to the power changes of ripple. Results: The main low frequency band modulating ictal-ripple activities was the θ band (4–8 Hz), and after completion of ictal-ripple burst, δ (1–4 Hz)-ripple PAC occurred. The ripple power increased simultaneously with rhythmic fluctuations from the seizure onset zone, and spread to other regions. Conclusions: Ripple activities during seizure evolution were modulated by the θ phase. The PAC phenomenon was visualized as rhythmic fluctuations. Significance: Ripple power associated with seizure evolution increased and spread with fluctuations. The θ oscillations related to the fluctuations might represent the common neurophysiological processing involved in seizure generation.
DC.rights	©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
DC.format	95539
citation_title	Phase-amplitude coupling of ripple activities during seizure evolution with theta phase
citation_author	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Kishima, Haruhiko
	Hirata, Masayuki
citation_publisher	Elsevier Ireland Ltd
citation_language	English
citation_date	2021-06-01
citation_journal_title	Clinical Neurophysiology
citation_volume	132
citation_issue	6
citation_firstpage	1243
citation_lastpage	1253
citation_doi	https://doi.org/10.1016/j.clinph.2021.03.007
citation_public_url	https://hdl.handle.net/11094/95539

Phase-amplitude coupling of ripple activities during seizure evolution with theta phase

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