Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi; Tani, Naoki; Oshino, Satoru; Kishima, Haruhiko; Hirata, Masayuki

doi:https://doi.org/10.1038/s41598-021-96479-1

Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi et al.

Scientific Reports, 2021, 11, 17405

Number of Access:1,613（2025-10-19 17:29 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95628

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Title	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
Creator	NRID 1000050770674 1000050770674 ORCID 0000-0003-4057-4466 0000-0003-4057-4466 researchmap permalink yousyou0720 yousyou0720 Scopus Author ID 56922570200 56922570200 CreatorName Hashimoto, Hiroaki
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 CreatorName Khoo, Hui Ming
	NRID 1000090533802 1000090533802 researchmap permalink takufumi takufumi Scopus Author ID 16553812400 16553812400 ORCID 0000-0002-2057-0612 0000-0002-2057-0612 CreatorName Yanagisawa, Takufumi
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 CreatorName Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
	NRID 1000030372626 1000030372626 researchmap permalink hiratty hiratty Scopus Author ID 7403352253 7403352253 CreatorName Hirata, Masayuki
Description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states. Scientific Reports 11, 17405 (2021); https://doi.org/10.1038/s41598-021-96479-1.
Abstract	Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	11
Page	17405
Date of Issued	2021-08-31
Language	English
Handle URL	https://hdl.handle.net/11094/95628
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-021-96479-1
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2021, 11, p. 17405
DC.title	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
DC.creator	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Kishima, Haruhiko
	Hirata, Masayuki
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-08-31
DC.identifier	https://doi.org/10.1038/s41598-021-96479-1
DC.description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states. Scientific Reports 11, 17405 (2021); https://doi.org/10.1038/s41598-021-96479-1.
DCTERMS.abstract	Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	95628
citation_title	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
citation_author	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Kishima, Haruhiko
	Hirata, Masayuki
citation_publisher	Nature Research
citation_language	English
citation_date	2021-08-31
citation_journal_title	Scientific Reports
citation_volume	11
citation_firstpage	17405
citation_doi	https://doi.org/10.1038/s41598-021-96479-1
citation_public_url	https://hdl.handle.net/11094/95628

Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states

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