Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi; Tani, Naoki; Oshino, Satoru; Hirata, Masayuki; Kishima, Haruhiko

doi:https://doi.org/10.1016/j.clinph.2022.02.015

Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band

Hashimoto, Hiroaki; Khoo, Hui Ming; Yanagisawa, Takufumi et al.

Clinical Neurophysiology, 2022, 137, 122-131

Number of Access:1,512（2025-08-15 01:09 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95630

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Title	Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band
Creator	NRID 1000050770674 1000050770674 ORCID 0000-0003-4057-4466 0000-0003-4057-4466 researchmap permalink yousyou0720 yousyou0720 Scopus Author ID 56922570200 56922570200 CreatorName Hashimoto, Hiroaki
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 CreatorName Khoo, Hui Ming
	NRID 1000090533802 1000090533802 researchmap permalink takufumi takufumi Scopus Author ID 16553812400 16553812400 ORCID 0000-0002-2057-0612 0000-0002-2057-0612 CreatorName Yanagisawa, Takufumi
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 CreatorName Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	NRID 1000030372626 1000030372626 researchmap permalink hiratty hiratty Scopus Author ID 7403352253 7403352253 CreatorName Hirata, Masayuki
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
Subject	Delta band
	Focal to bilateral tonic-clonic seizures
	High-frequency activities
	Intracranial EEG
	Phase-amplitude coupling
	Theta band
Description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band. Clinical Neurophysiology 137, 122 (2022); https://doi.org/10.1016/j.clinph.2022.02.015.
Abstract	Objective: To clarify variations in the relationship between high-frequency activities (HFAs) and low-frequency bands from the tonic to the clonic phase in focal to bilateral tonic-clonic seizures (FBTCS), using phase-amplitude coupling. Methods: This retrospective study enrolled six patients with drug-resistant focal epilepsy who underwent intracranial electrode placement at Osaka University Hospital (July 2018–July 2019). We recorded 11 FBTCS. The synchronization index (SI) and receiver-operating characteristic (ROC) analysis were used to analyze the coupling between HFA amplitude (80–250 Hz) and lower frequencies phase. Results: In the tonic phase, the θ (4–8 Hz)-HFA coupling peaked, and the HFA power occurred at baseline (0 μV) of θ oscillations. In contrast, in the clonic phase, the δ (2–4 Hz)-HFA coupling peaked, and the HFA power occurred at the trough of δ oscillations. ROC analysis indicated that the δ-HFA SI discriminated well the clonic from the tonic phase. Conclusions: The main low-frequency band modulating the HFA shifted from the θ band in the tonic phase to the δ band in the clonic phase. Significance: Neurophysiological key frequency bands were implied to be the θ band and δ band in tonic and clonic seizures, respectively, which improves our understanding of FBTCS.
Publisher	Elsevier Ireland Ltd
Source Title	Clinical Neurophysiology
Volume (Issue)	137
Page	122-131
Date of Issued	2022-05-01
Language	English
Handle URL	https://hdl.handle.net/11094/95630
PISSN	13882457
eISSN	18728952
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.clinph.2022.02.015
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Clinical Neurophysiology. 2022, 137, p. 122-131
DC.title	Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band
DC.creator	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Hirata, Masayuki
	Kishima, Haruhiko
DC.publisher	Elsevier Ireland Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-05-01
DC.identifier	https://doi.org/10.1016/j.clinph.2022.02.015
DC.subject	Delta band
	Focal to bilateral tonic-clonic seizures
	High-frequency activities
	Intracranial EEG
	Phase-amplitude coupling
	Theta band
DC.description	Hashimoto H., Khoo H.M., Yanagisawa T., et al. Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band. Clinical Neurophysiology 137, 122 (2022); https://doi.org/10.1016/j.clinph.2022.02.015.
DCTERMS.abstract	Objective: To clarify variations in the relationship between high-frequency activities (HFAs) and low-frequency bands from the tonic to the clonic phase in focal to bilateral tonic-clonic seizures (FBTCS), using phase-amplitude coupling. Methods: This retrospective study enrolled six patients with drug-resistant focal epilepsy who underwent intracranial electrode placement at Osaka University Hospital (July 2018–July 2019). We recorded 11 FBTCS. The synchronization index (SI) and receiver-operating characteristic (ROC) analysis were used to analyze the coupling between HFA amplitude (80–250 Hz) and lower frequencies phase. Results: In the tonic phase, the θ (4–8 Hz)-HFA coupling peaked, and the HFA power occurred at baseline (0 μV) of θ oscillations. In contrast, in the clonic phase, the δ (2–4 Hz)-HFA coupling peaked, and the HFA power occurred at the trough of δ oscillations. ROC analysis indicated that the δ-HFA SI discriminated well the clonic from the tonic phase. Conclusions: The main low-frequency band modulating the HFA shifted from the θ band in the tonic phase to the δ band in the clonic phase. Significance: Neurophysiological key frequency bands were implied to be the θ band and δ band in tonic and clonic seizures, respectively, which improves our understanding of FBTCS.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	95630
citation_title	Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band
citation_author	Hashimoto, Hiroaki
	Khoo, Hui Ming
	Yanagisawa, Takufumi
	Tani, Naoki
	Oshino, Satoru
	Hirata, Masayuki
	Kishima, Haruhiko
citation_publisher	Elsevier Ireland Ltd
citation_language	English
citation_date	2022-05-01
citation_journal_title	Clinical Neurophysiology
citation_volume	137
citation_firstpage	122
citation_lastpage	131
citation_doi	https://doi.org/10.1016/j.clinph.2022.02.015
citation_public_url	https://hdl.handle.net/11094/95630

Frequency band coupling with high-frequency activities in tonic-clonic seizures shifts from θ to δ band

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