The significant role of glycosaminoglycans in tooth development

Inubushi, Toshihiro; Nag, Priyanka; Sasaki, Jun-Ichi et al.

Glycobiology, 2024, 34(5), cwae024

Number of Access:142（2025-05-29 14:34 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95648

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Title
The significant role of glycosaminoglycans in tooth development
Creator
NRID
1000030550941 1000030550941
researchmap permalink
opathone0141 opathone0141
Scopus Author ID
23097933700 23097933700
ORCID
0000-0001-5303-4763 0000-0001-5303-4763
CreatorName
Inubushi, Toshihiro
CreatorName
Nag, Priyanka
NRID
1000050530490 1000050530490
researchmap permalink
Sasaki_JI Sasaki_JI
Scopus Author ID
36138008500 36138008500
CreatorName
Sasaki, Jun-Ichi
NRID
1000040912457 1000040912457
researchmap permalink
shiraishiyuki shiraishiyuki
CreatorName
Shiraishi, Yuki
NRID
1000070294428 1000070294428
ORCID
0000-0002-4419-9643 0000-0002-4419-9643
researchmap permalink
read0051793 read0051793
Scopus Author ID
55416765600 55416765600
CreatorName
Yamashiro, Takashi
Subject
extracellular matrix
glycosaminoglycan
hyaluronic acid
proteoglycan
tooth development
Description
Inubushi T., Nag P., Sasaki J.I., et al. The significant role of glycosaminoglycans in tooth development. Glycobiology 34, cwae024 (2024); https://doi.org/10.1093/glycob/cwae024.
Abstract
This review delves into the roles of glycosaminoglycans (GAGs), integral components of proteoglycans, in tooth development. Proteoglycans consist of a core protein linked to GAG chains, comprised of repeating disaccharide units. GAGs are classified into several types, such as hyaluronic acid, heparan sulfate, chondroitin sulfate, dermatan sulfate, and keratan sulfate. Functioning as critical macromolecular components within the dental basement membrane, these GAGs facilitate cell adhesion and aggregation, and play key roles in regulating cell proliferation and differentiation, thereby significantly influencing tooth morphogenesis. Notably, our recent research has identified the hyaluronan-degrading enzyme Transmembrane protein 2 (Tmem2) and we have conducted functional analyses using mouse models. These studies have unveiled the essential role of Tmem2-mediated hyaluronan degradation and its involvement in hyaluronan-mediated cell adhesion during tooth formation. This review provides a comprehensive summary of the current understanding of GAG functions in tooth development, integrating insights from recent research, and discusses future directions in this field.
Publisher
Oxford University Press
Source Title
Glycobiology
Volume (Issue)
34(5)
Page
cwae024
Date of Issued
2024-05-01
Language
English
Handle URL
https://hdl.handle.net/11094/95648
PISSN
09596658
eISSN
14602423
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1093/glycob/cwae024
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article