The impact of crystal phase transition on the hardness and structure of kidney stones

Michibata, Uta; Maruyama, Mihoko; Tanaka, Yutaro; Yoshimura, Masashi; Yoshikawa, Hiroshi Y.; Takano, Kazufumi; Furukawa, Yoshihiro; Momma, Koichi; Tajiri, Rie; Taguchi, Kazumi; Hamamoto, Shuzo; Okada, Atsushi; Kohri, Kenjiro; Yasui, Takahiro; Usami, Shigeyoshi; Imanishi, Masayuki; Mori, Yusuke

doi:https://doi.org/10.1007/s00240-024-01556-5

The impact of crystal phase transition on the hardness and structure of kidney stones

Michibata, Uta; Maruyama, Mihoko; Tanaka, Yutaro et al.

Urolithiasis, 2024, 52, 57

Number of Access:2,775（2025-08-01 09:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95724

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Title	The impact of crystal phase transition on the hardness and structure of kidney stones
Creator	CreatorName Michibata, Uta
	NRID 1000020623903 1000020623903 ORCID 0000-0002-3453-8007 0000-0002-3453-8007 researchmap permalink marumarumi marumarumi Scopus Author ID 35307485800 35307485800 CreatorName Maruyama, Mihoko
	NRID 1000070813434 1000070813434 researchmap permalink yutaro-tanaka yutaro-tanaka CreatorName Tanaka, Yutaro
	NRID 1000060314382 1000060314382 researchmap permalink read0191199 read0191199 Scopus Author ID 7403136552 7403136552 ORCID 0000-0002-0770-1251 0000-0002-0770-1251 CreatorName Yoshimura, Masashi
	NRID 1000050551173 1000050551173 ORCID 0000-0003-0624-6039 0000-0003-0624-6039 researchmap permalink read0108058 read0108058 Scopus Author ID 55708129100 55708129100 CreatorName Yoshikawa, Hiroshi Y.
	NRID 1000040346185 1000040346185 CreatorName Takano, Kazufumi
	NRID 1000000544107 1000000544107 CreatorName Furukawa, Yoshihiro
	NRID 1000030552781 1000030552781 CreatorName Momma, Koichi
	CreatorName Tajiri, Rie
	NRID 1000000595184 1000000595184 CreatorName Taguchi, Kazumi
	NRID 1000080551267 1000080551267 CreatorName Hamamoto, Shuzo
	NRID 1000070444966 1000070444966 CreatorName Okada, Atsushi
	NRID 1000030122047 1000030122047 CreatorName Kohri, Kenjiro
	NRID 1000040326153 1000040326153 CreatorName Yasui, Takahiro
	NRID 1000030897947 1000030897947 researchmap permalink s_usami s_usami Scopus Author ID 56770778200 56770778200 ORCID 0000-0002-9710-1718 0000-0002-9710-1718 CreatorName Usami, Shigeyoshi
	NRID 1000000795487 1000000795487 researchmap permalink Na-flux Na-flux Scopus Author ID 55361211900 55361211900 ORCID 0000-0001-9395-1750 0000-0001-9395-1750 CreatorName Imanishi, Masayuki
	NRID 1000090252618 1000090252618 ORCID 0000-0003-2952-7458 0000-0003-2952-7458 researchmap permalink mori_yusuke mori_yusuke Scopus Author ID 7404197134 7404197134 CreatorName Mori, Yusuke
Subject	Calcium oxalate
	Extracorporeal shock wave lithotripter
	Kidney stones
	Microstructure
	Solution-mediated phase transition
	X-ray micro-CT
Description	The version of record of this article, first published in Urolithiasis, is available online at Publisher’s website: https://doi.org/10.1007/s00240-024-01556-5.
Abstract	Calcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-step process of crystal nucleation, growth, aggregation, and secondary transition. The secondary transition has been rather overlooked, and thus, the effects on the disease and the underlying mechanism remain unclear. Here, we show, by periodic micro-CT images of human kidney stones in an ex vivo incubation experiment, that the growth of porous aggregates of calcium oxalate dihydrate (COD) crystals triggers the hardening of the kidney stones that causes difficulty in lithotripsy of kidney stone disease in the secondary transition. This hardening was caused by the internal nucleation and growth of precise calcium oxalate monohydrate (COM) crystals from isolated urine in which the calcium oxalate concentrations decreased by the growth of COD in closed grain boundaries of COD aggregate kidney stones. Reducing the calcium oxalate concentrations in urine is regarded as a typical approach for avoiding the recurrence. However, our results revealed that the decrease of the concentrations in closed microenvironments conversely promotes the transition of the COD aggregates into hard COM aggregates. We anticipate that the suppression of the secondary transition has the potential to manage the deterioration of kidney stone disease.
Publisher	Springer Science and Business Media Deutschland GmbH
Source Title	Urolithiasis
Volume (Issue)	52
Page	57
Date of Issued	2024-04-02
Language	English
Handle URL	https://hdl.handle.net/11094/95724
PISSN	21947228
eISSN	21947236
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00240-024-01556-5
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Urolithiasis. 2024, 52, p. 57
DC.title	The impact of crystal phase transition on the hardness and structure of kidney stones
DC.creator	Michibata, Uta
	Maruyama, Mihoko
	Tanaka, Yutaro
	Yoshimura, Masashi
	Yoshikawa, Hiroshi Y.
	Takano, Kazufumi
	Furukawa, Yoshihiro
	Momma, Koichi
	Tajiri, Rie
	Taguchi, Kazumi
	Hamamoto, Shuzo
	Okada, Atsushi
	Kohri, Kenjiro
	Yasui, Takahiro
	Usami, Shigeyoshi
	Imanishi, Masayuki
	Mori, Yusuke
DC.publisher	Springer Science and Business Media Deutschland GmbH
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-02
DC.identifier	https://doi.org/10.1007/s00240-024-01556-5
DC.subject	Calcium oxalate
	Extracorporeal shock wave lithotripter
	Kidney stones
	Microstructure
	Solution-mediated phase transition
	X-ray micro-CT
DC.description	The version of record of this article, first published in Urolithiasis, is available online at Publisher’s website: https://doi.org/10.1007/s00240-024-01556-5.
DCTERMS.abstract	Calcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-step process of crystal nucleation, growth, aggregation, and secondary transition. The secondary transition has been rather overlooked, and thus, the effects on the disease and the underlying mechanism remain unclear. Here, we show, by periodic micro-CT images of human kidney stones in an ex vivo incubation experiment, that the growth of porous aggregates of calcium oxalate dihydrate (COD) crystals triggers the hardening of the kidney stones that causes difficulty in lithotripsy of kidney stone disease in the secondary transition. This hardening was caused by the internal nucleation and growth of precise calcium oxalate monohydrate (COM) crystals from isolated urine in which the calcium oxalate concentrations decreased by the growth of COD in closed grain boundaries of COD aggregate kidney stones. Reducing the calcium oxalate concentrations in urine is regarded as a typical approach for avoiding the recurrence. However, our results revealed that the decrease of the concentrations in closed microenvironments conversely promotes the transition of the COD aggregates into hard COM aggregates. We anticipate that the suppression of the secondary transition has the potential to manage the deterioration of kidney stone disease.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	95724
citation_title	The impact of crystal phase transition on the hardness and structure of kidney stones
citation_author	Michibata, Uta
	Maruyama, Mihoko
	Tanaka, Yutaro
	Yoshimura, Masashi
	Yoshikawa, Hiroshi Y.
	Takano, Kazufumi
	Furukawa, Yoshihiro
	Momma, Koichi
	Tajiri, Rie
	Taguchi, Kazumi
	Hamamoto, Shuzo
	Okada, Atsushi
	Kohri, Kenjiro
	Yasui, Takahiro
	Usami, Shigeyoshi
	Imanishi, Masayuki
	Mori, Yusuke
citation_publisher	Springer Science and Business Media Deutschland GmbH
citation_language	English
citation_date	2024-04-02
citation_journal_title	Urolithiasis
citation_volume	52
citation_firstpage	57
citation_doi	https://doi.org/10.1007/s00240-024-01556-5
citation_public_url	https://hdl.handle.net/11094/95724

The impact of crystal phase transition on the hardness and structure of kidney stones

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