Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

Ihara, Fumiaki; Kyan, Hisako; Takashima, Yasuhiro; Ono, Fumiko; Hayashi, Kei; Matsuo, Tomohide; Igarashi, Makoto; Nishikawa, Yoshifumi; Hikosaka, Kenji; Sakamoto, Hirokazu; Nakamura, Shota; Motooka, Daisuke; Yamauchi, Kiyoshi; Ichikawa-Seki, Madoka; Fukumoto, Shinya; Sasaki, Motoki; Ikadai, Hiromi; Kusakisako, Kodai; Ohari, Yuma; Yoshida, Ayako; Sasai, Miwa; Grigg, Michael E.; Yamamoto, Masahiro

doi:https://doi.org/10.1038/s41467-024-47625-6

Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

Ihara, Fumiaki; Kyan, Hisako; Takashima, Yasuhiro et al.

Nature Communications, 2024, 15, 4278

Number of Access:2,526（2025-08-18 16:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95776

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
NatCommun_15_4278	pdf	None	4.23 MB	63	2024.05.31

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages
Creator	NRID 1000000800773 1000000800773 researchmap permalink fihara fihara CreatorName Ihara, Fumiaki
	CreatorName Kyan, Hisako
	NRID 1000020333552 1000020333552 CreatorName Takashima, Yasuhiro
	CreatorName Ono, Fumiko
	NRID 1000090823196 1000090823196 CreatorName Hayashi, Kei
	NRID 1000050383667 1000050383667 CreatorName Matsuo, Tomohide
	NRID 1000060374766 1000060374766 CreatorName Igarashi, Makoto
	NRID 1000090431395 1000090431395 CreatorName Nishikawa, Yoshifumi
	NRID 1000030456933 1000030456933 CreatorName Hikosaka, Kenji
	NRID 1000040724349 1000040724349 CreatorName Sakamoto, Hirokazu
	CreatorName Nakamura, Shota
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	NRID 1000020506315 1000020506315 CreatorName Yamauchi, Kiyoshi
	NRID 1000020700488 1000020700488 CreatorName Ichikawa-Seki, Madoka
	NRID 1000050376422 1000050376422 CreatorName Fukumoto, Shinya
	NRID 1000050332482 1000050332482 CreatorName Sasaki, Motoki
	NRID 1000080327460 1000080327460 CreatorName Ikadai, Hiromi
	NRID 1000010838220 1000010838220 CreatorName Kusakisako, Kodai
	NRID 1000000847056 1000000847056 CreatorName Ohari, Yuma
	NRID 1000020343486 1000020343486 CreatorName Yoshida, Ayako
	NRID 1000030631551 1000030631551 ORCID 0000-0001-6440-3958 0000-0001-6440-3958 researchmap permalink miwa-s miwa-s Scopus Author ID 16319941500 16319941500 CreatorName Sasai, Miwa
	CreatorName Grigg, Michael E.
	NRID 1000000444521 1000000444521 researchmap permalink read0151116 read0151116 Scopus Author ID 55552856200 55552856200 CreatorName Yamamoto, Masahiro
Description	Ihara F., Kyan H., Takashima Y., et al. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages. Nature Communications 15, 4278 (2024); https://doi.org/10.1038/s41467-024-47625-6.
Abstract	Toxoplasma gondii is a global protozoan pathogen. Clonal lineages predominate in Europe, North America, Africa, and China, whereas highly recombinant parasites are endemic in South/Central America. Far East Asian T. gondii isolates are not included in current global population genetic structure analyses at WGS resolution. Here we report a genome-wide population study that compared eight Japanese and two Chinese isolates against representative worldwide T. gondii genomes using POPSICLE, a novel population structure analyzing software. Also included were 7 genomes resurrected from non-viable isolates by target enrichment sequencing. Visualization of the genome structure by POPSICLE shows a mixture of Chinese haplogroup (HG) 13 haploblocks introgressed within the genomes of Japanese HG2 and North American HG12. Furthermore, two ancestral lineages were identified in the Japanese strains; one lineage shares a common ancestor with HG11 found in both Japanese strains and North American HG12. The other ancestral lineage, found in T. gondii isolates from a small island in Japan, is admixed with genetically diversified South/Central American strains. Taken together, this study suggests multiple ancestral links between Far East Asian and American T. gondii strains and provides insight into the transmission history of this cosmopolitan organism.
Publisher	Nature Research
Source Title	Nature Communications
Volume (Issue)	15
Page	4278
Date of Issued	2024-05-22
Language	English
Handle URL	https://hdl.handle.net/11094/95776
eISSN	20411723
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41467-024-47625-6
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Nature Communications. 2024, 15, p. 4278
DC.title	Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages
DC.creator	Ihara, Fumiaki
	Kyan, Hisako
	Takashima, Yasuhiro
	Ono, Fumiko
	Hayashi, Kei
	Matsuo, Tomohide
	Igarashi, Makoto
	Nishikawa, Yoshifumi
	Hikosaka, Kenji
	Sakamoto, Hirokazu
	Nakamura, Shota
	Motooka, Daisuke
	Yamauchi, Kiyoshi
	Ichikawa-Seki, Madoka
	Fukumoto, Shinya
	Sasaki, Motoki
	Ikadai, Hiromi
	Kusakisako, Kodai
	Ohari, Yuma
	Yoshida, Ayako
	Sasai, Miwa
	Grigg, Michael E.
	Yamamoto, Masahiro
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-22
DC.identifier	https://doi.org/10.1038/s41467-024-47625-6
DC.description	Ihara F., Kyan H., Takashima Y., et al. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages. Nature Communications 15, 4278 (2024); https://doi.org/10.1038/s41467-024-47625-6.
DCTERMS.abstract	Toxoplasma gondii is a global protozoan pathogen. Clonal lineages predominate in Europe, North America, Africa, and China, whereas highly recombinant parasites are endemic in South/Central America. Far East Asian T. gondii isolates are not included in current global population genetic structure analyses at WGS resolution. Here we report a genome-wide population study that compared eight Japanese and two Chinese isolates against representative worldwide T. gondii genomes using POPSICLE, a novel population structure analyzing software. Also included were 7 genomes resurrected from non-viable isolates by target enrichment sequencing. Visualization of the genome structure by POPSICLE shows a mixture of Chinese haplogroup (HG) 13 haploblocks introgressed within the genomes of Japanese HG2 and North American HG12. Furthermore, two ancestral lineages were identified in the Japanese strains; one lineage shares a common ancestor with HG11 found in both Japanese strains and North American HG12. The other ancestral lineage, found in T. gondii isolates from a small island in Japan, is admixed with genetically diversified South/Central American strains. Taken together, this study suggests multiple ancestral links between Far East Asian and American T. gondii strains and provides insight into the transmission history of this cosmopolitan organism.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	95776
citation_title	Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages
citation_author	Ihara, Fumiaki
	Kyan, Hisako
	Takashima, Yasuhiro
	Ono, Fumiko
	Hayashi, Kei
	Matsuo, Tomohide
	Igarashi, Makoto
	Nishikawa, Yoshifumi
	Hikosaka, Kenji
	Sakamoto, Hirokazu
	Nakamura, Shota
	Motooka, Daisuke
	Yamauchi, Kiyoshi
	Ichikawa-Seki, Madoka
	Fukumoto, Shinya
	Sasaki, Motoki
	Ikadai, Hiromi
	Kusakisako, Kodai
	Ohari, Yuma
	Yoshida, Ayako
	Sasai, Miwa
	Grigg, Michael E.
	Yamamoto, Masahiro
citation_publisher	Nature Research
citation_language	English
citation_date	2024-05-22
citation_journal_title	Nature Communications
citation_volume	15
citation_firstpage	4278
citation_doi	https://doi.org/10.1038/s41467-024-47625-6
citation_public_url	https://hdl.handle.net/11094/95776

Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

Link to primary information

Item Information

Show details