Impact of serum autotaxin level correlating with histological findings in biliary atresia

Ueno, Takehisa; Toyama, Chiyoshi; Yoneyama, Tomohisa; Deguchi, Koichi; Nomura, Motonari; Saka, Ryuta; Watanabe, Miho; Tazuke, Yuko; Bessho, Kazuhiko; Okuyama, Hiroomi

doi:https://doi.org/10.1016/j.jpedsurg.2021.03.034

Impact of serum autotaxin level correlating with histological findings in biliary atresia

Ueno, Takehisa; Toyama, Chiyoshi; Yoneyama, Tomohisa et al.

Journal of Pediatric Surgery, 2021, 56(7), 1174-1178

Number of Access:1,241（2025-07-22 21:58 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/96432

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Title	Impact of serum autotaxin level correlating with histological findings in biliary atresia
Creator	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, Takehisa
	NRID 1000010839369 1000010839369 CreatorName Toyama, Chiyoshi
	NRID 1000000839368 1000000839368 CreatorName Yoneyama, Tomohisa
	NRID 1000000747082 1000000747082 researchmap permalink deguchi_koichi deguchi_koichi Scopus Author ID 57139781700 57139781700 CreatorName Deguchi, Koichi
	NRID 1000040546909 1000040546909 researchmap permalink moto_pedsurg moto_pedsurg Scopus Author ID 35208741700 35208741700 ORCID 0009-0004-0959-7461 0009-0004-0959-7461 CreatorName Nomura, Motonari
	NRID 1000000459190 1000000459190 ORCID 0000-0001-8960-8618 0000-0001-8960-8618 researchmap permalink sakaryuta sakaryuta CreatorName Saka, Ryuta
	NRID 1000040791728 1000040791728 researchmap permalink miho miho Scopus Author ID 56282966800 56282966800 ORCID 0000-0001-6691-0611 0000-0001-6691-0611 CreatorName Watanabe, Miho
	NRID 1000010397698 1000010397698 researchmap permalink yukotazuke-osaka yukotazuke-osaka Scopus Author ID 7006109798 7006109798 ORCID 0000-0002-8335-0414 0000-0002-8335-0414 CreatorName Tazuke, Yuko
	NRID 1000080423169 1000080423169 researchmap permalink KazuBe KazuBe CreatorName Bessho, Kazuhiko
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, Hiroomi
Subject	Cirrhosis
	Fibrosis marker
	Liver biopsy
	Liver fibrosis
	Liver transplantation
Description	Ueno T., Toyama C., Yoneyama T., et al. Impact of serum autotaxin level correlating with histological findings in biliary atresia. Journal of Pediatric Surgery 56, 1174 (2021); https://doi.org/10.1016/j.jpedsurg.2021.03.034.
Abstract	Purpose: Portoenterostomy is the standard treatment for biliary atresia (BA) that reduces jaundice in two thirds of cases. However, progressive liver fibrosis is common, leading to cirrhosis in most patients. Autotaxin is a new marker for the progression of hepatic fibrosis. We examined the relationship between serum autotaxin levels and liver histological findings in patients with BA. Methods: BA patients with native livers were identified in our hospital. Patients underwent protocol liver biopsies every 1 to 5 years, and liver fibrosis was evaluated based on the METAVIR score. Serum autotaxin levels were compared with the last available pathological findings. Results: Thirty-five patients were included and the median age was 10.6 years. Serum autotaxin levels was median 1.6 mg/L. The mean autotaxin level was 1.08 mg/L in F0, 1.07 mg/L in F1, 0.95 mg/L in F2, 2.17 mg/L in F3, and 2.50 mg/L in F4; it was significantly higher in F4 than in F0–F2 (P<0.0024). For predicting cirrhosis (F4) and advanced liver fibrosis (≥F3), autotaxin had the almost same areas under the curve (AUCs 0.78 and 0.90, respectively) as well as M2BPGi. Conclusion: Autotaxin levels could be used to evaluate the status of native liver fibrosis.
Publisher	Elsevier
Source Title	Journal of Pediatric Surgery
Volume (Issue)	56(7)
Page	1174-1178
Date of Issued	2021-07-01
Language	English
Handle URL	https://hdl.handle.net/11094/96432
PISSN	00223468
eISSN	15315037
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/j.jpedsurg.2021.03.034
Access Rights	open access
CopyRight	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Journal of Pediatric Surgery. 2021, 56(7), p. 1174-1178
DC.title	Impact of serum autotaxin level correlating with histological findings in biliary atresia
DC.creator	Ueno, Takehisa
	Toyama, Chiyoshi
	Yoneyama, Tomohisa
	Deguchi, Koichi
	Nomura, Motonari
	Saka, Ryuta
	Watanabe, Miho
	Tazuke, Yuko
	Bessho, Kazuhiko
	Okuyama, Hiroomi
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-07-01
DC.identifier	https://doi.org/10.1016/j.jpedsurg.2021.03.034
DC.subject	Cirrhosis
	Fibrosis marker
	Liver biopsy
	Liver fibrosis
	Liver transplantation
DC.description	Ueno T., Toyama C., Yoneyama T., et al. Impact of serum autotaxin level correlating with histological findings in biliary atresia. Journal of Pediatric Surgery 56, 1174 (2021); https://doi.org/10.1016/j.jpedsurg.2021.03.034.
DCTERMS.abstract	Purpose: Portoenterostomy is the standard treatment for biliary atresia (BA) that reduces jaundice in two thirds of cases. However, progressive liver fibrosis is common, leading to cirrhosis in most patients. Autotaxin is a new marker for the progression of hepatic fibrosis. We examined the relationship between serum autotaxin levels and liver histological findings in patients with BA. Methods: BA patients with native livers were identified in our hospital. Patients underwent protocol liver biopsies every 1 to 5 years, and liver fibrosis was evaluated based on the METAVIR score. Serum autotaxin levels were compared with the last available pathological findings. Results: Thirty-five patients were included and the median age was 10.6 years. Serum autotaxin levels was median 1.6 mg/L. The mean autotaxin level was 1.08 mg/L in F0, 1.07 mg/L in F1, 0.95 mg/L in F2, 2.17 mg/L in F3, and 2.50 mg/L in F4; it was significantly higher in F4 than in F0–F2 (P<0.0024). For predicting cirrhosis (F4) and advanced liver fibrosis (≥F3), autotaxin had the almost same areas under the curve (AUCs 0.78 and 0.90, respectively) as well as M2BPGi. Conclusion: Autotaxin levels could be used to evaluate the status of native liver fibrosis.
DC.rights	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	96432
citation_title	Impact of serum autotaxin level correlating with histological findings in biliary atresia
citation_author	Ueno, Takehisa
	Toyama, Chiyoshi
	Yoneyama, Tomohisa
	Deguchi, Koichi
	Nomura, Motonari
	Saka, Ryuta
	Watanabe, Miho
	Tazuke, Yuko
	Bessho, Kazuhiko
	Okuyama, Hiroomi
citation_publisher	Elsevier
citation_language	English
citation_date	2021-07-01
citation_journal_title	Journal of Pediatric Surgery
citation_volume	56
citation_issue	7
citation_firstpage	1174
citation_lastpage	1178
citation_doi	https://doi.org/10.1016/j.jpedsurg.2021.03.034
citation_public_url	https://hdl.handle.net/11094/96432

Impact of serum autotaxin level correlating with histological findings in biliary atresia

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