Association between interstitial lung abnormality and mortality in patients with esophageal cancer

Hata, Akinori; Yanagawa, Masahiro; Miyata, Tomo; Hiraoka, Yu; Shirae, Motohiro; Ninomiya, Keisuke; Doi, Shuhei; Yamagata, Kazuki; Yoshida, Yuriko; Kikuchi, Noriko; Ogawa, Ryo; Hatabu, Hiroto; Tomiyama, Noriyuki

doi:https://doi.org/10.1007/s11604-024-01563-x

Association between interstitial lung abnormality and mortality in patients with esophageal cancer

Hata, Akinori; Yanagawa, Masahiro; Miyata, Tomo et al.

Japanese Journal of Radiology, 2024, 42(8), 841-851

Number of Access:1,248（2025-08-14 00:03 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/96467

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
JpnJRad_s11604_024_01563_x	pdf	None	1.19 MB	112	2024.06.27

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Association between interstitial lung abnormality and mortality in patients with esophageal cancer
Creator	NRID 1000010838600 1000010838600 researchmap permalink hataakinori hataakinori Scopus Author ID 57188730692 57188730692 CreatorName Hata, Akinori
	NRID 1000000546872 1000000546872 ORCID 0000-0002-0911-6769 0000-0002-0911-6769 researchmap permalink myMY3434 myMY3434 Scopus Author ID 36891136200 36891136200 CreatorName Yanagawa, Masahiro
	CreatorName Miyata, Tomo
	CreatorName Hiraoka, Yu
	CreatorName Shirae, Motohiro
	CreatorName Ninomiya, Keisuke
	CreatorName Doi, Shuhei
	CreatorName Yamagata, Kazuki
	researchmap permalink yuriko-yoshida yuriko-yoshida CreatorName Yoshida, Yuriko
	CreatorName Kikuchi, Noriko
	NRID 1000050895654 1000050895654 researchmap permalink 234e 234e CreatorName Ogawa, Ryo
	CreatorName Hatabu, Hiroto
	NRID 1000050294070 1000050294070 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
Subject	Chest
	Computed tomography
	Esophageal cancer
	Interstitial lung abnormalities
	Interstitial lung disease
	X-ray
Description	The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: https://doi.org/10.1007/s11604-024-01563-x.
Abstract	Purpose: To investigate the relationship between interstitial lung abnormalities (ILAs) and mortality in patients with esophageal cancer and the cause of mortality. Materials and methods: This retrospective study investigated patients with esophageal cancer from January 2011 to December 2015. ILAs were visually scored on baseline CT using a 3-point scale (0 = non-ILA, 1 = indeterminate for ILA, and 2 = ILA). ILAs were classified into subcategories of non-subpleural, subpleural non-fibrotic, and subpleural fibrotic. Five-year overall survival (OS) was compared between patients with and without ILAs using the multivariable Cox proportional hazards model. Subgroup analyses were performed based on cancer stage and ILA subcategories. The prevalences of treatment complications and death due to esophageal cancer and pneumonia/respiratory failure were analyzed using Fisher’s exact test. Results: A total of 478 patients with esophageal cancer (age, 66.8 years ± 8.6 [standard deviation]; 64 women) were evaluated in this study. Among them, 267 patients showed no ILAs, 125 patients were indeterminate for ILAs, and 86 patients showed ILAs. ILAs were a significant factor for shorter OS (hazard ratio [HR] = 1.68, 95% confidence interval [CI] 1.10–2.55, P = 0.016) in the multivariable Cox proportional hazards model adjusting for age, sex, smoking history, clinical stage, and histology. On subgroup analysis using patients with clinical stage IVB, the presence of ILAs was a significant factor (HR = 3.78, 95% CI 1.67–8.54, P = 0.001). Subpleural fibrotic ILAs were significantly associated with shorter OS (HR = 2.22, 95% CI 1.25–3.93, P = 0.006). There was no significant difference in treatment complications. Patients with ILAs showed a higher prevalence of death due to pneumonia/respiratory failure than those without ILAs (non-ILA, 2/95 [2%]; ILA, 5/39 [13%]; P = 0.022). The prevalence of death due to esophageal cancer was similar in patients with and without ILA (non-ILA, 82/95 [86%]; ILA 32/39 [82%]; P = 0.596). Conclusion: ILAs were significantly associated with shorter survival in patients with esophageal cancer.
Publisher	Springer
Source Title	Japanese Journal of Radiology
Volume (Issue)	42(8)
Page	841-851
Date of Issued	2024-04-25
Language	English
Handle URL	https://hdl.handle.net/11094/96467
PISSN	18671071
eISSN	1867108X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s11604-024-01563-x
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Japanese Journal of Radiology. 2024, 42(8), p. 841-851
DC.title	Association between interstitial lung abnormality and mortality in patients with esophageal cancer
DC.creator	Hata, Akinori
	Yanagawa, Masahiro
	Miyata, Tomo
	Hiraoka, Yu
	Shirae, Motohiro
	Ninomiya, Keisuke
	Doi, Shuhei
	Yamagata, Kazuki
	Yoshida, Yuriko
	Kikuchi, Noriko
	Ogawa, Ryo
	Hatabu, Hiroto
	Tomiyama, Noriyuki
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-25
DC.identifier	https://doi.org/10.1007/s11604-024-01563-x
DC.subject	Chest
	Computed tomography
	Esophageal cancer
	Interstitial lung abnormalities
	Interstitial lung disease
	X-ray
DC.description	The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: https://doi.org/10.1007/s11604-024-01563-x.
DCTERMS.abstract	Purpose: To investigate the relationship between interstitial lung abnormalities (ILAs) and mortality in patients with esophageal cancer and the cause of mortality. Materials and methods: This retrospective study investigated patients with esophageal cancer from January 2011 to December 2015. ILAs were visually scored on baseline CT using a 3-point scale (0 = non-ILA, 1 = indeterminate for ILA, and 2 = ILA). ILAs were classified into subcategories of non-subpleural, subpleural non-fibrotic, and subpleural fibrotic. Five-year overall survival (OS) was compared between patients with and without ILAs using the multivariable Cox proportional hazards model. Subgroup analyses were performed based on cancer stage and ILA subcategories. The prevalences of treatment complications and death due to esophageal cancer and pneumonia/respiratory failure were analyzed using Fisher’s exact test. Results: A total of 478 patients with esophageal cancer (age, 66.8 years ± 8.6 [standard deviation]; 64 women) were evaluated in this study. Among them, 267 patients showed no ILAs, 125 patients were indeterminate for ILAs, and 86 patients showed ILAs. ILAs were a significant factor for shorter OS (hazard ratio [HR] = 1.68, 95% confidence interval [CI] 1.10–2.55, P = 0.016) in the multivariable Cox proportional hazards model adjusting for age, sex, smoking history, clinical stage, and histology. On subgroup analysis using patients with clinical stage IVB, the presence of ILAs was a significant factor (HR = 3.78, 95% CI 1.67–8.54, P = 0.001). Subpleural fibrotic ILAs were significantly associated with shorter OS (HR = 2.22, 95% CI 1.25–3.93, P = 0.006). There was no significant difference in treatment complications. Patients with ILAs showed a higher prevalence of death due to pneumonia/respiratory failure than those without ILAs (non-ILA, 2/95 [2%]; ILA, 5/39 [13%]; P = 0.022). The prevalence of death due to esophageal cancer was similar in patients with and without ILA (non-ILA, 82/95 [86%]; ILA 32/39 [82%]; P = 0.596). Conclusion: ILAs were significantly associated with shorter survival in patients with esophageal cancer.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	96467
citation_title	Association between interstitial lung abnormality and mortality in patients with esophageal cancer
citation_author	Hata, Akinori
	Yanagawa, Masahiro
	Miyata, Tomo
	Hiraoka, Yu
	Shirae, Motohiro
	Ninomiya, Keisuke
	Doi, Shuhei
	Yamagata, Kazuki
	Yoshida, Yuriko
	Kikuchi, Noriko
	Ogawa, Ryo
	Hatabu, Hiroto
	Tomiyama, Noriyuki
citation_publisher	Springer
citation_language	English
citation_date	2024-04-25
citation_journal_title	Japanese Journal of Radiology
citation_volume	42
citation_issue	8
citation_firstpage	841
citation_lastpage	851
citation_doi	https://doi.org/10.1007/s11604-024-01563-x
citation_public_url	https://hdl.handle.net/11094/96467

Association between interstitial lung abnormality and mortality in patients with esophageal cancer

Link to primary information

Item Information

Show details