Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia

Ueno, Takehisa; Kodama, Tasuku; Noguchi, Yuki; Saka, Ryuta; Takama, Yuichi; Tazuke, Yuko; Bessho, Kazuhiko; Okuyama, Hiroomi

doi:https://doi.org/10.1007/S00383-018-4317-2

Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia

Ueno, Takehisa; Kodama, Tasuku; Noguchi, Yuki et al.

Pediatric Surgery International, 2018, 34(10), 1065-1071

Number of Access:883（2025-07-22 22:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/96470

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available
PediatrSurgInt_34_10_1065	pdf	None	302 KB	50	2024.06.28
PediatrSurgInt_34_10_1065_figure	pdf	None	138 KB	21	2024.06.28
PediatrSurgInt_34_10_1065_table	pdf	None	199 KB	24	2024.06.28

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia
Creator	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, Takehisa
	CreatorName Kodama, Tasuku
	CreatorName Noguchi, Yuki
	NRID 1000000459190 1000000459190 ORCID 0000-0001-8960-8618 0000-0001-8960-8618 researchmap permalink sakaryuta sakaryuta CreatorName Saka, Ryuta
	NRID 1000050467560 1000050467560 researchmap permalink tytyty_ytytyt tytyty_ytytyt CreatorName Takama, Yuichi
	NRID 1000010397698 1000010397698 researchmap permalink yukotazuke-osaka yukotazuke-osaka Scopus Author ID 7006109798 7006109798 ORCID 0000-0002-8335-0414 0000-0002-8335-0414 CreatorName Tazuke, Yuko
	NRID 1000080423169 1000080423169 CreatorName Bessho, Kazuhiko
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, Hiroomi
Subject	APRI
	Biliary atresia
	FIB-4
	Liver fibrosis
	Liver transplantation
Description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/S00383-018-4317-2
Abstract	Purpose: The Mac-2-binding protein glycosylation-modified isomer (M2BPGi) is a new marker for progression of hepatic fibrosis. We examined the relationship between serum M2BPGi levels and liver histological findings in patients with biliary atresia (BA) who were not transplant candidates. Methods: Patients with BA who were not transplant candidates with good liver function were included. We examined M2BPGi levels and histological findings in relation to other laboratory markers of liver fibrosis, including aspartate aminotransferase (AST) to platelet ratio index, fibrosis-4 index, and type IV collagen 7s domain. Liver fibrosis was evaluated based on the METVIR score. Results: 37 patients were included. The median age was 18 years (range 3–38 years). M2BPGi values ranged from 0.3 to 6.9 cutoff index (COI) (median 1.6). The degree of liver fibrosis varied with M2BPGi level. For predicting cirrhosis (F4) and advanced liver fibrosis (≥ F3), M2BPGi had higher areas under the curve (AUCs; 0.93, respectively) with cutoff COIs of 1.84 and 1.67, respectively, than for the four conventional markers for fibrosis. Conclusion: M2BPGi is a novel marker for liver fibrosis in patients with BA. It is especially useful for following patients with BA with a native liver and supporting liver biopsy interpretation findings.
Publisher	Springer Verlagservice@springer.de
Source Title	Pediatric Surgery International
Volume (Issue)	34(10)
Page	1065-1071
Date of Issued	2018-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/96470
PISSN	01790358
eISSN	14379813
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1007/S00383-018-4317-2
Access Rights	open access
CopyRight	© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Pediatric Surgery International. 2018, 34(10), p. 1065-1071
DC.title	Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia
DC.creator	Ueno, Takehisa
	Kodama, Tasuku
	Noguchi, Yuki
	Saka, Ryuta
	Takama, Yuichi
	Tazuke, Yuko
	Bessho, Kazuhiko
	Okuyama, Hiroomi
DC.publisher	Springer Verlagservice@springer.de
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-10-01
DC.identifier	https://doi.org/10.1007/S00383-018-4317-2
DC.subject	APRI
	Biliary atresia
	FIB-4
	Liver fibrosis
	Liver transplantation
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/S00383-018-4317-2
DCTERMS.abstract	Purpose: The Mac-2-binding protein glycosylation-modified isomer (M2BPGi) is a new marker for progression of hepatic fibrosis. We examined the relationship between serum M2BPGi levels and liver histological findings in patients with biliary atresia (BA) who were not transplant candidates. Methods: Patients with BA who were not transplant candidates with good liver function were included. We examined M2BPGi levels and histological findings in relation to other laboratory markers of liver fibrosis, including aspartate aminotransferase (AST) to platelet ratio index, fibrosis-4 index, and type IV collagen 7s domain. Liver fibrosis was evaluated based on the METVIR score. Results: 37 patients were included. The median age was 18 years (range 3–38 years). M2BPGi values ranged from 0.3 to 6.9 cutoff index (COI) (median 1.6). The degree of liver fibrosis varied with M2BPGi level. For predicting cirrhosis (F4) and advanced liver fibrosis (≥ F3), M2BPGi had higher areas under the curve (AUCs; 0.93, respectively) with cutoff COIs of 1.84 and 1.67, respectively, than for the four conventional markers for fibrosis. Conclusion: M2BPGi is a novel marker for liver fibrosis in patients with BA. It is especially useful for following patients with BA with a native liver and supporting liver biopsy interpretation findings.
DC.rights	© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
DC.format	96470
citation_title	Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia
citation_author	Ueno, Takehisa
	Kodama, Tasuku
	Noguchi, Yuki
	Saka, Ryuta
	Takama, Yuichi
	Tazuke, Yuko
	Bessho, Kazuhiko
	Okuyama, Hiroomi
citation_publisher	Springer Verlagservice@springer.de
citation_language	English
citation_date	2018-10-01
citation_journal_title	Pediatric Surgery International
citation_volume	34
citation_issue	10
citation_firstpage	1065
citation_lastpage	1071
citation_doi	https://doi.org/10.1007/S00383-018-4317-2
citation_public_url	https://hdl.handle.net/11094/96470

Clinical implications of serum Mac-2-binding protein (M2BPGi) during regular follow-up of patients with biliary atresia

Link to primary information

Item Information

Show details