How should cardiac xenotransplantation be initiated in Japan?

Saito, Shunsuke; Miyagawa, Shuji; Kawamura, Takuji; Yoshioka, Daisuke; Kawamura, Masashi; Kawamura, Ai; Misumi, Yusuke; Taguchi, Takura; Yamauchi, Takashi; Miyagawa, Shigeru

doi:https://doi.org/10.1007/s00595-024-02861-7

How should cardiac xenotransplantation be initiated in Japan?

Saito, Shunsuke; Miyagawa, Shuji; Kawamura, Takuji et al.

Surgery Today, 2024, 54(8), 829-838

Number of Access:1,431（2025-07-22 20:40 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97115

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Title	How should cardiac xenotransplantation be initiated in Japan?
Creator	NRID 1000030600126 1000030600126 ORCID 0000-0002-0829-2891 0000-0002-0829-2891 researchmap permalink shunsaito shunsaito Scopus Author ID 57205524320 57205524320 CreatorName Saito, Shunsuke
	NRID 1000090273648 1000090273648 researchmap permalink read0185079 read0185079 CreatorName Miyagawa, Shuji
	NRID 1000060839398 1000060839398 researchmap permalink takuji-kawamura takuji-kawamura Scopus Author ID 55331768500 55331768500 ORCID 0000-0003-2985-0036 0000-0003-2985-0036 CreatorName Kawamura, Takuji
	NRID 1000040645959 1000040645959 researchmap permalink d-yoshioka d-yoshioka Scopus Author ID 7003892845 7003892845 CreatorName Yoshioka, Daisuke
	NRID 1000070583011 1000070583011 researchmap permalink mk_mk mk_mk CreatorName Kawamura, Masashi
	NRID 1000010838923 1000010838923 researchmap permalink a-kawamura a-kawamura Scopus Author ID 56414159900 56414159900 CreatorName Kawamura, Ai
	NRID 1000020631477 1000020631477 researchmap permalink yusukemisumi yusukemisumi CreatorName Misumi, Yusuke
	CreatorName Taguchi, Takura
	NRID 1000020527999 1000020527999 CreatorName Yamauchi, Takashi
	NRID 1000070544237 1000070544237 ORCID 0000-0003-0015-6569 0000-0003-0015-6569 researchmap permalink s-miyagawa3154 s-miyagawa3154 Scopus Author ID 55560624700 55560624700 CreatorName Miyagawa, Shigeru
Subject	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Hyperacute rejection
	Pig
Description	The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: https://doi.org/10.1007/s00595-024-02861-7.
Abstract	The world's first clinical cardiac xenotransplantation, using a genetically engineered pig heart with 10 gene modifications, prolonged the life of a 57-year-old man with no other life-saving options, by 60 days. It is foreseeable that xenotransplantation will be introduced in clinical practice in the United States. However, little clinical or regulatory progress has been made in the field of xenotransplantation in Japan in recent years. Japan seems to be heading toward a "device lag", and the over-importation of medical devices and technology in the medical field is becoming problematic. In this review, we discuss the concept of pig-heart xenotransplantation, including the pathobiological aspects related to immune rejection, coagulation dysregulation, and detrimental heart overgrowth, as well as genetic modification strategies in pigs to prevent or minimize these problems. Moreover, we summarize the necessity for and current status of xenotransplantation worldwide, and future prospects in Japan, with the aim of initiating xenotransplantation in Japan using genetically modified pigs without a global delay. It is imperative that this study prompts the initiation of preclinical xenotransplantation research using non-human primates and leads to clinical studies.
Publisher	Springer
Source Title	Surgery Today
Volume (Issue)	54(8)
Page	829-838
Date of Issued	2024-05-11
Language	English
Handle URL	https://hdl.handle.net/11094/97115
PISSN	09411291
eISSN	14362813
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00595-024-02861-7
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Surgery Today. 2024, 54(8), p. 829-838
DC.title	How should cardiac xenotransplantation be initiated in Japan?
DC.creator	Saito, Shunsuke
	Miyagawa, Shuji
	Kawamura, Takuji
	Yoshioka, Daisuke
	Kawamura, Masashi
	Kawamura, Ai
	Misumi, Yusuke
	Taguchi, Takura
	Yamauchi, Takashi
	Miyagawa, Shigeru
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-11
DC.identifier	https://doi.org/10.1007/s00595-024-02861-7
DC.subject	Cardiac xenotransplantation
	End-stage heart failure
	Genetic engineering
	Hyperacute rejection
	Pig
DC.description	The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: https://doi.org/10.1007/s00595-024-02861-7.
DCTERMS.abstract	The world's first clinical cardiac xenotransplantation, using a genetically engineered pig heart with 10 gene modifications, prolonged the life of a 57-year-old man with no other life-saving options, by 60 days. It is foreseeable that xenotransplantation will be introduced in clinical practice in the United States. However, little clinical or regulatory progress has been made in the field of xenotransplantation in Japan in recent years. Japan seems to be heading toward a "device lag", and the over-importation of medical devices and technology in the medical field is becoming problematic. In this review, we discuss the concept of pig-heart xenotransplantation, including the pathobiological aspects related to immune rejection, coagulation dysregulation, and detrimental heart overgrowth, as well as genetic modification strategies in pigs to prevent or minimize these problems. Moreover, we summarize the necessity for and current status of xenotransplantation worldwide, and future prospects in Japan, with the aim of initiating xenotransplantation in Japan using genetically modified pigs without a global delay. It is imperative that this study prompts the initiation of preclinical xenotransplantation research using non-human primates and leads to clinical studies.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97115
citation_title	How should cardiac xenotransplantation be initiated in Japan?
citation_author	Saito, Shunsuke
	Miyagawa, Shuji
	Kawamura, Takuji
	Yoshioka, Daisuke
	Kawamura, Masashi
	Kawamura, Ai
	Misumi, Yusuke
	Taguchi, Takura
	Yamauchi, Takashi
	Miyagawa, Shigeru
citation_publisher	Springer
citation_language	English
citation_date	2024-05-11
citation_journal_title	Surgery Today
citation_volume	54
citation_issue	8
citation_firstpage	829
citation_lastpage	838
citation_doi	https://doi.org/10.1007/s00595-024-02861-7
citation_public_url	https://hdl.handle.net/11094/97115

How should cardiac xenotransplantation be initiated in Japan?

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