Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Yuba, Tomoo; Koyama, Yoshihisa; Kinishi, Yuki; Uokawa, Reiko; Ootaki, Chiyo; Shimada, Shoichi; Fujino, Yuji

doi:https://doi.org/10.1007/s43032-024-01580-1

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Yuba, Tomoo; Koyama, Yoshihisa; Kinishi, Yuki et al.

Reproductive Sciences, 2024, 31(9), 2753-2762

Number of Access:831（2025-08-16 03:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97117

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
ReprodSci_s43032-024-01580-1	pdf	None	1.67 MB	202	2024.07.05

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
Creator	CreatorName Yuba, Tomoo
	NRID 1000040397667 1000040397667 researchmap permalink koyamayoshihisa koyamayoshihisa Scopus Author ID 49761644100 49761644100 CreatorName Koyama, Yoshihisa
	CreatorName Kinishi, Yuki
	CreatorName Uokawa, Reiko
	NRID 1000000742248 1000000742248 researchmap permalink otc5386 otc5386 Scopus Author ID 14045558000 14045558000 CreatorName Ootaki, Chiyo
	NRID 1000020216063 1000020216063 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 CreatorName Shimada, Shoichi
	NRID 1000050252672 1000050252672 researchmap permalink y_fujino y_fujino Scopus Author ID 19134445600 19134445600 CreatorName Fujino, Yuji
Subject	Fetus
	Labor epidural analgesia
	Mother
	Oxidative stress
Description	The version of record of this article, first published in Reproductive Sciences, is available online at Publisher’s website: https://doi.org/10.1007/s43032-024-01580-1.
Abstract	Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.
Publisher	Springer Nature
Source Title	Reproductive Sciences
Volume (Issue)	31(9)
Page	2753-2762
Date of Issued	2024-05-10
Language	English
Handle URL	https://hdl.handle.net/11094/97117
PISSN	19337191
eISSN	19337205
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s43032-024-01580-1
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Reproductive Sciences. 2024, 31(9), p. 2753-2762
DC.title	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
DC.creator	Yuba, Tomoo
	Koyama, Yoshihisa
	Kinishi, Yuki
	Uokawa, Reiko
	Ootaki, Chiyo
	Shimada, Shoichi
	Fujino, Yuji
DC.publisher	Springer Nature
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-10
DC.identifier	https://doi.org/10.1007/s43032-024-01580-1
DC.subject	Fetus
	Labor epidural analgesia
	Mother
	Oxidative stress
DC.description	The version of record of this article, first published in Reproductive Sciences, is available online at Publisher’s website: https://doi.org/10.1007/s43032-024-01580-1.
DCTERMS.abstract	Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97117
citation_title	Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia
citation_author	Yuba, Tomoo
	Koyama, Yoshihisa
	Kinishi, Yuki
	Uokawa, Reiko
	Ootaki, Chiyo
	Shimada, Shoichi
	Fujino, Yuji
citation_publisher	Springer Nature
citation_language	English
citation_date	2024-05-10
citation_journal_title	Reproductive Sciences
citation_volume	31
citation_issue	9
citation_firstpage	2753
citation_lastpage	2762
citation_doi	https://doi.org/10.1007/s43032-024-01580-1
citation_public_url	https://hdl.handle.net/11094/97117

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Link to primary information

Item Information

Show details