Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates

Iwata, Takamitsu; Oshino, Satoru; Saitoh, Youichi; Kinoshita, Manabu; Onoda, Yuji; Kijima, Noriyuki; Mukai, Kosuke; Otsuki, Michio; Kishima, Haruhiko

doi:https://doi.org/10.1007/s11102-024-01395-y

Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates

Iwata, Takamitsu; Oshino, Satoru; Saitoh, Youichi et al.

Pituitary, 2024, 27, 287-293

Number of Access:38（2025-05-02 12:15 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97119

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Title	Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates
Creator	researchmap permalink takamitsuiwata takamitsuiwata ORCID 0000-0003-2533-0551 0000-0003-2533-0551 CreatorName Iwata, Takamitsu
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	CreatorName Saitoh, Youichi
	NRID 1000040448064 1000040448064 researchmap permalink manabukinoshita manabukinoshita CreatorName Kinoshita, Manabu
	CreatorName Onoda, Yuji
	NRID 1000080534627 1000080534627 researchmap permalink kiji kiji Scopus Author ID 53463724600 53463724600 ORCID 0000-0003-2103-1909 0000-0003-2103-1909 CreatorName Kijima, Noriyuki
	NRID 1000020815352 1000020815352 researchmap permalink mukai mukai Scopus Author ID 55045414800 55045414800 CreatorName Mukai, Kosuke
	NRID 1000000403056 1000000403056 CreatorName Otsuki, Michio
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
Subject	Cyst contents
	Prognosis
	Rathke’s cleft cysts
	Transsphenoidal surgery
Description	The version of record of this article, first published in Pituitary, is available online at Publisher’s website: https://doi.org/10.1007/s11102-024-01395-y.
Abstract	Purpose: The contents of Rathke’s cleft cysts (RCCs) vary from clear and slightly viscous to purulent. Surgical treatment of symptomatic RCCs involves removing the cyst contents, whereas additional cyst-wall opening to prevent reaccumulation is at the surgeon’s discretion. The macroscopic findings of the cyst content can reflect the nature of RCCs and would aid in surgical method selection. Methods: We retrospectively reviewed the records of 42 patients with symptomatic RCCs who underwent transsphenoidal surgery at our institute between January 2010 and March 2022. According to the intraoperative findings, cyst contents were classified into type A (purulent), type B (turbid white with mixed semisolids), or type C (clear and slightly viscous). Clinical and imaging findings and early recurrence rate (within two years) were compared according to the cyst content type. Results: There were 42 patients classified into three types. Patients with type C were the oldest (65.4 ± 10.4 years), and type A included more females (92.9%). For magnetic resonance imaging, type-A patients showed contrast-enhanced cyst wall (92.9%), type-B patients had intracystic nodules (57.1%), and all type-C patients showed low T1 and high T2 intensities with larger cyst volumes. Fewer asymptomatic patients had type C. Preoperative pituitary dysfunction was most common in type A (71.4%). Early recurrence was observed in types A and C, which were considered candidates for cyst-wall opening. Conclusion: The clinical characteristics and surgical prognosis of RCCs depend on the nature of their contents.
Publisher	Springer
Source Title	Pituitary
Volume (Issue)	27
Page	287-293
Date of Issued	2024-06-01
Language	English
Handle URL	https://hdl.handle.net/11094/97119
PISSN	1386341X
eISSN	15737403
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s11102-024-01395-y
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Pituitary. 2024, 27, p. 287-293
DC.title	Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates
DC.creator	Iwata, Takamitsu
	Oshino, Satoru
	Saitoh, Youichi
	Kinoshita, Manabu
	Onoda, Yuji
	Kijima, Noriyuki
	Mukai, Kosuke
	Otsuki, Michio
	Kishima, Haruhiko
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-01
DC.identifier	https://doi.org/10.1007/s11102-024-01395-y
DC.subject	Cyst contents
	Prognosis
	Rathke’s cleft cysts
	Transsphenoidal surgery
DC.description	The version of record of this article, first published in Pituitary, is available online at Publisher’s website: https://doi.org/10.1007/s11102-024-01395-y.
DCTERMS.abstract	Purpose: The contents of Rathke’s cleft cysts (RCCs) vary from clear and slightly viscous to purulent. Surgical treatment of symptomatic RCCs involves removing the cyst contents, whereas additional cyst-wall opening to prevent reaccumulation is at the surgeon’s discretion. The macroscopic findings of the cyst content can reflect the nature of RCCs and would aid in surgical method selection. Methods: We retrospectively reviewed the records of 42 patients with symptomatic RCCs who underwent transsphenoidal surgery at our institute between January 2010 and March 2022. According to the intraoperative findings, cyst contents were classified into type A (purulent), type B (turbid white with mixed semisolids), or type C (clear and slightly viscous). Clinical and imaging findings and early recurrence rate (within two years) were compared according to the cyst content type. Results: There were 42 patients classified into three types. Patients with type C were the oldest (65.4 ± 10.4 years), and type A included more females (92.9%). For magnetic resonance imaging, type-A patients showed contrast-enhanced cyst wall (92.9%), type-B patients had intracystic nodules (57.1%), and all type-C patients showed low T1 and high T2 intensities with larger cyst volumes. Fewer asymptomatic patients had type C. Preoperative pituitary dysfunction was most common in type A (71.4%). Early recurrence was observed in types A and C, which were considered candidates for cyst-wall opening. Conclusion: The clinical characteristics and surgical prognosis of RCCs depend on the nature of their contents.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97119
citation_title	Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates
citation_author	Iwata, Takamitsu
	Oshino, Satoru
	Saitoh, Youichi
	Kinoshita, Manabu
	Onoda, Yuji
	Kijima, Noriyuki
	Mukai, Kosuke
	Otsuki, Michio
	Kishima, Haruhiko
citation_publisher	Springer
citation_language	English
citation_date	2024-06-01
citation_journal_title	Pituitary
citation_volume	27
citation_firstpage	287
citation_lastpage	293
citation_doi	https://doi.org/10.1007/s11102-024-01395-y
citation_public_url	https://hdl.handle.net/11094/97119

Appearance of fluid content in Rathke’s cleft cyst is associated with clinical features and postoperative recurrence rates

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