Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

Matsumura, Erika; Nohara, Kanji; Fukatsu, Hikari; Tanaka, Nobukazu; Fujii, Nami; Sakai, Takayoshi

doi:https://doi.org/10.1007/s00455-024-10704-3

Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

Matsumura, Erika; Nohara, Kanji; Fukatsu, Hikari et al.

Dysphagia, 2024, 40(1), 70-76

Number of Access:578（2025-08-14 12:34 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97120

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Title	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
Creator	CreatorName Matsumura, Erika
	NRID 1000020346167 1000020346167 researchmap permalink read0093430 read0093430 Scopus Author ID 7004385707 7004385707 ORCID 0000-0001-8254-4615 0000-0001-8254-4615 CreatorName Nohara, Kanji
	CreatorName Fukatsu, Hikari
	NRID 1000020570295 1000020570295 researchmap permalink hal-1008 hal-1008 Scopus Author ID 55702171000 55702171000 ORCID 0000-0002-5877-0214 0000-0002-5877-0214 CreatorName Tanaka, Nobukazu
	NRID 1000090635377 1000090635377 ORCID 0000-0003-3670-3085 0000-0003-3670-3085 researchmap permalink nanohana-3 nanohana-3 CreatorName Fujii, Nami
	NRID 1000090379082 1000090379082 ORCID 0000-0003-4348-4896 0000-0003-4348-4896 researchmap permalink read0210126 read0210126 Scopus Author ID 55177911100 55177911100 CreatorName Sakai, Takayoshi
Subject	Aspiration pneumonia
	Dysphagia
	Mucociliary transport function
	Saccharine dye test
	Thickening agent
	Viscosity
Description	The version of record of this article, first published in Dysphagia, is available online at Publisher’s website: https://doi.org/10.1007/s00455-024-10704-3.
Abstract	Thickening agents effectively prevent liquid aspiration, but their impact on the ease of discharging aspirated liquids from the trachea remains unclear due to alterations in the physical properties of liquids. This study clarifies the effects of thickening agents, comprising various raw materials, on mucociliary transport function, focusing on the viscosities of thickened waters. The subjects were 23 healthy adults. Five types of saccharin solution were prepared: a solution without a thickening agent, a starch-based nectar-like solution, a starch-based honey-like solution, a xanthan-gum-based nectar-like solution, and a xanthan-gum-based honey-like solution. Using these five types of saccharin solutions randomly, each subject underwent five trials of the saccharine dye test to evaluate the mucociliary transport function of the respiratory tract. The saccharin time was defined as the time from the placement of the saccharin solution on the nasal vestibule of the subject to when the subject reported that they became aware of the sweetness. The saccharin transit times for all samples of thickened water were longer compared to those of water without a thickening agent (p < 0.01). A comparison between thickened water samples with different viscosities showed that the saccharin transit time was longer when thickened water samples with high viscosity were prepared using the same thickening agent (p < 0.01). This suggests that while thickening reduces aspiration, the use of thickening agents may increase the difficulty in discharging aspirated fluids from the trachea.
Publisher	Springer
Source Title	Dysphagia
Volume (Issue)	40(1)
Page	70-76
Date of Issued	2024-05-22
Language	English
Handle URL	https://hdl.handle.net/11094/97120
PISSN	0179051X
eISSN	14320460
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00455-024-10704-3
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Dysphagia. 2024, 40(1), p. 70-76
DC.title	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
DC.creator	Matsumura, Erika
	Nohara, Kanji
	Fukatsu, Hikari
	Tanaka, Nobukazu
	Fujii, Nami
	Sakai, Takayoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-22
DC.identifier	https://doi.org/10.1007/s00455-024-10704-3
DC.subject	Aspiration pneumonia
	Dysphagia
	Mucociliary transport function
	Saccharine dye test
	Thickening agent
	Viscosity
DC.description	The version of record of this article, first published in Dysphagia, is available online at Publisher’s website: https://doi.org/10.1007/s00455-024-10704-3.
DCTERMS.abstract	Thickening agents effectively prevent liquid aspiration, but their impact on the ease of discharging aspirated liquids from the trachea remains unclear due to alterations in the physical properties of liquids. This study clarifies the effects of thickening agents, comprising various raw materials, on mucociliary transport function, focusing on the viscosities of thickened waters. The subjects were 23 healthy adults. Five types of saccharin solution were prepared: a solution without a thickening agent, a starch-based nectar-like solution, a starch-based honey-like solution, a xanthan-gum-based nectar-like solution, and a xanthan-gum-based honey-like solution. Using these five types of saccharin solutions randomly, each subject underwent five trials of the saccharine dye test to evaluate the mucociliary transport function of the respiratory tract. The saccharin time was defined as the time from the placement of the saccharin solution on the nasal vestibule of the subject to when the subject reported that they became aware of the sweetness. The saccharin transit times for all samples of thickened water were longer compared to those of water without a thickening agent (p < 0.01). A comparison between thickened water samples with different viscosities showed that the saccharin transit time was longer when thickened water samples with high viscosity were prepared using the same thickening agent (p < 0.01). This suggests that while thickening reduces aspiration, the use of thickening agents may increase the difficulty in discharging aspirated fluids from the trachea.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97120
citation_title	Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
citation_author	Matsumura, Erika
	Nohara, Kanji
	Fukatsu, Hikari
	Tanaka, Nobukazu
	Fujii, Nami
	Sakai, Takayoshi
citation_publisher	Springer
citation_language	English
citation_date	2024-05-22
citation_journal_title	Dysphagia
citation_volume	40
citation_issue	1
citation_firstpage	70
citation_lastpage	76
citation_doi	https://doi.org/10.1007/s00455-024-10704-3
citation_public_url	https://hdl.handle.net/11094/97120

Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water

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