Impact of Donor Age on Outcome of Intestinal Transplantation in Japan

Ueno, T.; Wada, M.; Hoshino, K.; Matsuura, T.; Okajima, H.; Okuyama, H.

doi:https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021

Impact of Donor Age on Outcome of Intestinal Transplantation in Japan

Ueno, T.; Wada, M.; Hoshino, K. et al.

Transplantation Proceedings, 2018, 50(9), 2775-2778

Number of Access:707（2025-07-22 22:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97127

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Title	Impact of Donor Age on Outcome of Intestinal Transplantation in Japan
Creator	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, T.
	NRID 1000080372291 1000080372291 CreatorName Wada, M.
	NRID 1000070190197 1000070190197 CreatorName Hoshino, K.
	NRID 1000010532856 1000010532856 CreatorName Matsuura, T.
	NRID 1000020308604 1000020308604 CreatorName Okajima, H.
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, H.
Description	Ueno T., Wada M., Hoshino K., et al. Impact of Donor Age on Outcome of Intestinal Transplantation in Japan. Transplantation Proceedings 50, 2775 (2018); https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021.
Abstract	Background: Donor age for intestinal transplantation (ITx) is somewhat younger than that for other solid organs. Clear criteria for adequate donors have not been established. There is a donor scarcity for ITx in Japan due to the shortage of young donors. Methods: We reviewed outcomes associated with ITx in Japan based on donor age for cadaveric and living donation. Results: Standardized report forms were sent to all known ITx programs, asking for information on ITxs performed between 1996 and 2016. All programs responded. Patient and graft survival estimates were obtained using the Kaplan-Meier method. Five institutions provided data on 27 grafts in 24 patients. There were 14 cadaveric and 13 living donor transplants. Median donor age for ITxs was 40 (range, 17–60) years. Graft survival at 5 years was 66% for patients >40 years old (n = 18) and 47% for those <40 years old (n = 9), not a statistically significant difference (P =.49). Graft survival at 5 years was 60% in those >50 years old (n = 5) and 57% for those <50 years old (n = 22), again not a significant difference (P =.27). Conclusion: There is no difference in survival between for those with donor age <40 vs >40 years. Donor age for ITx can be extended from >40 to up to 50 years, which may help to mitigate the donor shortage. It will be necessary to clarify the donor criteria for ITx through accumulation of further data on ITx.
Publisher	Elsevier
Source Title	Transplantation Proceedings
Volume (Issue)	50(9)
Page	2775-2778
Date of Issued	2018-11-01
Language	English
Handle URL	https://hdl.handle.net/11094/97127
PISSN	00411345
eISSN	18732623
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021
Access Rights	open access
CopyRight	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2018, 50(9), p. 2775-2778
DC.title	Impact of Donor Age on Outcome of Intestinal Transplantation in Japan
DC.creator	Ueno, T.
	Wada, M.
	Hoshino, K.
	Matsuura, T.
	Okajima, H.
	Okuyama, H.
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-11-01
DC.identifier	https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021
DC.description	Ueno T., Wada M., Hoshino K., et al. Impact of Donor Age on Outcome of Intestinal Transplantation in Japan. Transplantation Proceedings 50, 2775 (2018); https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021.
DCTERMS.abstract	Background: Donor age for intestinal transplantation (ITx) is somewhat younger than that for other solid organs. Clear criteria for adequate donors have not been established. There is a donor scarcity for ITx in Japan due to the shortage of young donors. Methods: We reviewed outcomes associated with ITx in Japan based on donor age for cadaveric and living donation. Results: Standardized report forms were sent to all known ITx programs, asking for information on ITxs performed between 1996 and 2016. All programs responded. Patient and graft survival estimates were obtained using the Kaplan-Meier method. Five institutions provided data on 27 grafts in 24 patients. There were 14 cadaveric and 13 living donor transplants. Median donor age for ITxs was 40 (range, 17–60) years. Graft survival at 5 years was 66% for patients >40 years old (n = 18) and 47% for those <40 years old (n = 9), not a statistically significant difference (P =.49). Graft survival at 5 years was 60% in those >50 years old (n = 5) and 57% for those <50 years old (n = 22), again not a significant difference (P =.27). Conclusion: There is no difference in survival between for those with donor age <40 vs >40 years. Donor age for ITx can be extended from >40 to up to 50 years, which may help to mitigate the donor shortage. It will be necessary to clarify the donor criteria for ITx through accumulation of further data on ITx.
DC.rights	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	97127
citation_title	Impact of Donor Age on Outcome of Intestinal Transplantation in Japan
citation_author	Ueno, T.
	Wada, M.
	Hoshino, K.
	Matsuura, T.
	Okajima, H.
	Okuyama, H.
citation_publisher	Elsevier
citation_language	English
citation_date	2018-11-01
citation_journal_title	Transplantation Proceedings
citation_volume	50
citation_issue	9
citation_firstpage	2775
citation_lastpage	2778
citation_doi	https://doi.org/10.1016/J.TRANSPROCEED.2018.04.021
citation_public_url	https://hdl.handle.net/11094/97127

Impact of Donor Age on Outcome of Intestinal Transplantation in Japan

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