Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial

Omori, Takeshi; Yamamoto, Kazuyoshi; Kurokawa, Yukinori; Miyazaki, Yasuhiro; Fujitani, Kazumasa; Kawabata, Ryohei; Imamura, Hiroshi; Takeno, Atsushi; Yanagimoto, Yoshitomo; Takahashi, Tsuyoshi; Saito, Takuro; Eguchi, Hidetoshi; Doki, Yuichiro

doi:https://doi.org/10.1245/s10434-024-15667-1

Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial

Omori, Takeshi; Yamamoto, Kazuyoshi; Kurokawa, Yukinori et al.

Annals of Surgical Oncology, 2024, 31(10), 6909-6917

Number of Access:1,559（2025-08-14 12:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97132

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Title	Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial
Creator	NRID 1000040423181 1000040423181 CreatorName Omori, Takeshi
	NRID 1000070528637 1000070528637 researchmap permalink kymamoto13 kymamoto13 Scopus Author ID 12764120500 12764120500 CreatorName Yamamoto, Kazuyoshi
	NRID 1000010470197 1000010470197 researchmap permalink krkw krkw Scopus Author ID 7202562410 7202562410 CreatorName Kurokawa, Yukinori
	NRID 1000000571390 1000000571390 CreatorName Miyazaki, Yasuhiro
	CreatorName Fujitani, Kazumasa
	CreatorName Kawabata, Ryohei
	CreatorName Imamura, Hiroshi
	CreatorName Takeno, Atsushi
	CreatorName Yanagimoto, Yoshitomo
	CreatorName Takahashi, Tsuyoshi
	NRID 1000020646468 1000020646468 researchmap permalink tsaito19 tsaito19 Scopus Author ID 57211629912 57211629912 CreatorName Saito, Takuro
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 CreatorName Eguchi, Hidetoshi
	NRID 1000020291445 1000020291445 researchmap permalink ydoki3251 ydoki3251 Scopus Author ID 7006390687 7006390687 CreatorName Doki, Yuichiro
Description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1245/s10434-024-15667-1.
Abstract	Background : Weight loss (WL) after gastrectomy for gastric cancer is associated with both decreased compliance with adjuvant chemotherapy and impaired survival. This study examined the effects of administering oral nutritional supplements (ONS) for 3 months after gastrectomy in terms of compliance with adjuvant chemotherapy and survival outcomes. Methods : This large-scale, multicenter, open-label, randomized controlled trial enrolled 1,003 gastric cancer patients undergoing curative gastrectomy. Patients were assigned to the control group (n = 503) or ONS group (n = 500). In the ONS group, 400 kcal/day of ONS was recommended in addition to a regular diet for 3 months after gastrectomy. Compliance with adjuvant chemotherapy and survival outcomes were compared between the two groups. Results : Compared with the control group, the ONS group showed significantly decreased WL at 3 months after gastrectomy (8.6 ± 6.1 vs. 7.2 ± 5.7%, respectively, P = 0.0004). The control and ONS groups did not differ regarding the induction rate of adjuvant chemotherapy (84.9 vs. 82.8%, respectively, P = 0.614) or the continuation rate at 3 months postoperatively (75.3 vs. 76.6%, respectively, P = 0.809). Oral nutritional supplements for 3 months showed no survival benefit; the 3- and 5-year overall survival (OS) rates were 91.3% and 87.6% in the control group and 89.6% and 86.4% in the ONS group, respectively, indicating no significant difference (P = 0.548). Subgroup analysis could not detect a population in which ONS administration increased OS. Conclusions : Administration of ONS for 3 months after gastrectomy was not associated with increased compliance with adjuvant chemotherapy or with improved prognosis.
Publisher	Springer Science and Business Media LLC
Source Title	Annals of Surgical Oncology
Volume (Issue)	31(10)
Page	6909-6917
Date of Issued	2024-07-10
Handle URL	https://hdl.handle.net/11094/97132
PISSN	10689265
eISSN	15344681
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1245/s10434-024-15667-1
Access Rights	open access
CopyRight	© Society of Surgical Oncology 2024
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Annals of Surgical Oncology. 2024, 31(10), p. 6909-6917
DC.title	Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial
DC.creator	Omori, Takeshi
	Yamamoto, Kazuyoshi
	Kurokawa, Yukinori
	Miyazaki, Yasuhiro
	Fujitani, Kazumasa
	Kawabata, Ryohei
	Imamura, Hiroshi
	Takeno, Atsushi
	Yanagimoto, Yoshitomo
	Takahashi, Tsuyoshi
	Saito, Takuro
	Eguchi, Hidetoshi
	Doki, Yuichiro
DC.publisher	Springer Science and Business Media LLC
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-07-10
DC.identifier	https://doi.org/10.1245/s10434-024-15667-1
DC.description	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1245/s10434-024-15667-1.
DCTERMS.abstract	Background : Weight loss (WL) after gastrectomy for gastric cancer is associated with both decreased compliance with adjuvant chemotherapy and impaired survival. This study examined the effects of administering oral nutritional supplements (ONS) for 3 months after gastrectomy in terms of compliance with adjuvant chemotherapy and survival outcomes. Methods : This large-scale, multicenter, open-label, randomized controlled trial enrolled 1,003 gastric cancer patients undergoing curative gastrectomy. Patients were assigned to the control group (n = 503) or ONS group (n = 500). In the ONS group, 400 kcal/day of ONS was recommended in addition to a regular diet for 3 months after gastrectomy. Compliance with adjuvant chemotherapy and survival outcomes were compared between the two groups. Results : Compared with the control group, the ONS group showed significantly decreased WL at 3 months after gastrectomy (8.6 ± 6.1 vs. 7.2 ± 5.7%, respectively, P = 0.0004). The control and ONS groups did not differ regarding the induction rate of adjuvant chemotherapy (84.9 vs. 82.8%, respectively, P = 0.614) or the continuation rate at 3 months postoperatively (75.3 vs. 76.6%, respectively, P = 0.809). Oral nutritional supplements for 3 months showed no survival benefit; the 3- and 5-year overall survival (OS) rates were 91.3% and 87.6% in the control group and 89.6% and 86.4% in the ONS group, respectively, indicating no significant difference (P = 0.548). Subgroup analysis could not detect a population in which ONS administration increased OS. Conclusions : Administration of ONS for 3 months after gastrectomy was not associated with increased compliance with adjuvant chemotherapy or with improved prognosis.
DC.rights	© Society of Surgical Oncology 2024
DC.format	97132
citation_title	Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial
citation_author	Omori, Takeshi
	Yamamoto, Kazuyoshi
	Kurokawa, Yukinori
	Miyazaki, Yasuhiro
	Fujitani, Kazumasa
	Kawabata, Ryohei
	Imamura, Hiroshi
	Takeno, Atsushi
	Yanagimoto, Yoshitomo
	Takahashi, Tsuyoshi
	Saito, Takuro
	Eguchi, Hidetoshi
	Doki, Yuichiro
citation_publisher	Springer Science and Business Media LLC
citation_date	2024-07-10
citation_journal_title	Annals of Surgical Oncology
citation_volume	31
citation_issue	10
citation_firstpage	6909
citation_lastpage	6917
citation_doi	https://doi.org/10.1245/s10434-024-15667-1
citation_public_url	https://hdl.handle.net/11094/97132

Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial

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