Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan

Komatsu, Reina; Mimura, Kazuya; Matsuyama, Tatsuya et al.

Journal of Obstetrics and Gynaecology Research, 2024, 50(7), 1258-1262

Number of Access:876（2025-08-27 18:28 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97138

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Title
Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan
Creator
CreatorName
Komatsu, Reina
NRID
1000050437422 1000050437422
researchmap permalink
fm1906 fm1906
Scopus Author ID
17435267000 17435267000
CreatorName
Mimura, Kazuya
CreatorName
Matsuyama, Tatsuya
NRID
1000070876367 1000070876367
researchmap permalink
assembly assembly
Scopus Author ID
57205751220 57205751220
CreatorName
Kawanishi, Yoko
NRID
1000080467571 1000080467571
researchmap permalink
hitominakamura hitominakamura
Scopus Author ID
35750272100 35750272100
CreatorName
Nakamura, Hitomi
NRID
1000030346209 1000030346209
researchmap permalink
2019-10-31 2019-10-31
CreatorName
Tomimatsu, Takuji
NRID
1000030644794 1000030644794
researchmap permalink
CHOP CHOP
Scopus Author ID
35182871900 35182871900
CreatorName
Endo, Masayuki
NRID
1000090240845 1000090240845
researchmap permalink
read0106368 read0106368
Scopus Author ID
35421281200 35421281200
CreatorName
Kimura, Tadashi
Subject
atypical hemolytic uremic syndrome
HELLP syndrome
pre-eclampsia
pregnancy
thrombotic microangiopathy
Description
Komatsu R., Mimura K., Matsuyama T., et al. Severe hemolysis, elevated liver enzymes, and low platelet syndrome requiring differentiation of thrombotic microangiopathy: Four cases from a nationwide survey in Japan. Journal of Obstetrics and Gynaecology Research , (2024); https://doi.org/10.1111/jog.15949.
Abstract
Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire-based survey was conducted among obstetricians who are members of the Perinatal Research Network Group in Japan. There were a total of 335 cases of HELLP syndrome over a 3-year period in the 48 facilities that responded to the survey. Four patients required plasma exchange or dialysis, of which two were diagnosed with atypical hemolytic uremic syndrome and two with TMA secondary to systemic lupus erythematosus. Although such severe HELLP syndrome is rare, identifying the clinical features and making accurate differential diagnosis are critical for optimal clinical outcomes for mothers and neonates.
Publisher
John Wiley and Sons Inc
Source Title
Journal of Obstetrics and Gynaecology Research
Volume (Issue)
50(7)
Page
1258-1262
Date of Issued
2024-04-08
Language
English
Handle URL
https://hdl.handle.net/11094/97138
PISSN
13418076
eISSN
14470756
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1111/jog.15949
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article