Development and organization of omental milky spots

Okabe, Yasutaka

Immunological Reviews, 2024, 324(1), 68-77

Number of Access:68（2025-08-15 18:58 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97142

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Title
Development and organization of omental milky spots
Creator
NRID
1000050522124 1000050522124
researchmap permalink
7000018117 7000018117
Scopus Author ID
36917266300 36917266300
CreatorName
Okabe, Yasutaka
Subject
macrophage
milky spot
omentum
retinoic acid
Description
Okabe Y., . Development and organization of omental milky spots. Immunological Reviews , (2024); https://doi.org/10.1111/imr.13337.
Abstract
The milky spots in omentum are atypical lymphoid tissues that play a pivotal role in regulating immune responses in the peritoneal cavity. The milky spots act as central hubs for collecting antigens and particles from the peritoneal cavity, regulating lymphocyte trafficking, promoting the differentiation and self-renewal of immune cells, and supporting the local germinal centre response. In addition, the milky spots exhibit unique developmental characteristics that combine the features of secondary and tertiary lymphoid tissues. These structures are innately programmed to form during foetal development; however, they can also be formed postnatally in response to peritoneal irritation such as inflammation, infection, obesity, or tumour metastasis. In this review, I discuss emerging perspectives on homeostatic development and organization of the milky spots.
Publisher
John Wiley and Sons Inc
Source Title
Immunological Reviews
Volume (Issue)
324(1)
Page
68-77
Date of Issued
2024-04-25
Language
English
Handle URL
https://hdl.handle.net/11094/97142
PISSN
01052896
eISSN
1600065X
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1111/imr.13337
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article