Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore

Kawaguchi, Taiga; Tsutsui, Makusu; Murayama, Sanae; Leong, Iat Wai; Yokota, Kazumichi; Komoto, Yuki; Taniguchi, Masateru

doi:https://doi.org/10.1002/smtd.202301523

Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore

Kawaguchi, Taiga; Tsutsui, Makusu; Murayama, Sanae et al.

Small Methods, 2024, 8(8), 2301523

Number of Access:693（2025-10-25 03:26 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97145

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Title	Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore
Creator	CreatorName Kawaguchi, Taiga
	NRID 1000050546596 1000050546596 ORCID 0000-0002-4552-1163 0000-0002-4552-1163 researchmap permalink makusu makusu Scopus Author ID 8978905800 8978905800 CreatorName Tsutsui, Makusu
	CreatorName Murayama, Sanae
	CreatorName Leong, Iat Wai
	NRID 1000050633179 1000050633179 CreatorName Yokota, Kazumichi
	NRID 1000090814210 1000090814210 researchmap permalink YukiKomoto YukiKomoto Scopus Author ID 55942733700 55942733700 CreatorName Komoto, Yuki
	NRID 1000040362628 1000040362628 researchmap permalink read0076413 read0076413 Scopus Author ID 7402403092 7402403092 CreatorName Taniguchi, Masateru
Subject	dilatancy
	nanofluidics
	nanopores
	translocation dynamics
Description	Kawaguchi T., Tsutsui M., Murayama S., et al. Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore. Small Methods , (2024); https://doi.org/10.1002/smtd.202301523.
Abstract	Slowing down translocation dynamics is a crucial challenge in nanopore sensing of small molecules and particles. Here, it is reported on nanoparticle motion-mediated local viscosity enhancement of water-organic mixtures in a nanofluidic channel that enables slow translocation speed, enhanced capture efficiency, and improved signal-to-noise ratio by transmembrane voltage control. It is found that higher detection rates of nanoparticles under larger electrophoretic voltage in the highly viscous solvents. Meanwhile, the strongly pulled particles distort the liquid in the pore at high shear rates over 103 s−1 which leads to a counterintuitive phenomenon of slower translocation speed under higher voltage via the induced dilatant viscosity behavior. This mechanism is demonstrated as feasible with a variety of organic molecules, including glycerol, xanthan gum, and polyethylene glycol. The present findings can be useful in resistive pulse analyses of nanoscale objects such as viruses and proteins by allowing a simple and effective way for translocation slowdown, improved detection throughput, and enhanced signal-to-noise ratio.
Publisher	John Wiley and Sons Inc
Source Title	Small Methods
Volume (Issue)	8(8)
Page	2301523
Date of Issued	2024-05-09
Language	English
Handle URL	https://hdl.handle.net/11094/97145
eISSN	23669608
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1002/smtd.202301523
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Small Methods. 2024, 8(8), p. 2301523
DC.title	Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore
DC.creator	Kawaguchi, Taiga
	Tsutsui, Makusu
	Murayama, Sanae
	Leong, Iat Wai
	Yokota, Kazumichi
	Komoto, Yuki
	Taniguchi, Masateru
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-09
DC.identifier	https://doi.org/10.1002/smtd.202301523
DC.subject	dilatancy
	nanofluidics
	nanopores
	translocation dynamics
DC.description	Kawaguchi T., Tsutsui M., Murayama S., et al. Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore. Small Methods , (2024); https://doi.org/10.1002/smtd.202301523.
DCTERMS.abstract	Slowing down translocation dynamics is a crucial challenge in nanopore sensing of small molecules and particles. Here, it is reported on nanoparticle motion-mediated local viscosity enhancement of water-organic mixtures in a nanofluidic channel that enables slow translocation speed, enhanced capture efficiency, and improved signal-to-noise ratio by transmembrane voltage control. It is found that higher detection rates of nanoparticles under larger electrophoretic voltage in the highly viscous solvents. Meanwhile, the strongly pulled particles distort the liquid in the pore at high shear rates over 103 s−1 which leads to a counterintuitive phenomenon of slower translocation speed under higher voltage via the induced dilatant viscosity behavior. This mechanism is demonstrated as feasible with a variety of organic molecules, including glycerol, xanthan gum, and polyethylene glycol. The present findings can be useful in resistive pulse analyses of nanoscale objects such as viruses and proteins by allowing a simple and effective way for translocation slowdown, improved detection throughput, and enhanced signal-to-noise ratio.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	97145
citation_title	Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore
citation_author	Kawaguchi, Taiga
	Tsutsui, Makusu
	Murayama, Sanae
	Leong, Iat Wai
	Yokota, Kazumichi
	Komoto, Yuki
	Taniguchi, Masateru
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-05-09
citation_journal_title	Small Methods
citation_volume	8
citation_issue	8
citation_firstpage	2301523
citation_doi	https://doi.org/10.1002/smtd.202301523
citation_public_url	https://hdl.handle.net/11094/97145

Enhanced Nanoparticle Sensing in a Highly Viscous Nanopore

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