A mouse model of autoimmune inner ear disease without endolymphatic hydrops

Harada, Shotaro; Koyama, Yoshihisa; Imai, Takao; Yoshioka, Yoshichika; Sumi, Takuya; Inohara, Hidenori; Shimada, Shoichi

doi:https://doi.org/10.1016/j.bbadis.2024.167198

A mouse model of autoimmune inner ear disease without endolymphatic hydrops

Harada, Shotaro; Koyama, Yoshihisa; Imai, Takao et al.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2024, 1870(5), 167198

Number of Access:52（2025-04-30 13:17 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97163

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Title	A mouse model of autoimmune inner ear disease without endolymphatic hydrops
Creator	NRID 1000010824740 1000010824740 CreatorName Harada, Shotaro
	NRID 1000040397667 1000040397667 researchmap permalink koyamayoshihisa koyamayoshihisa Scopus Author ID 49761644100 49761644100 CreatorName Koyama, Yoshihisa
	NRID 1000080570663 1000080570663 CreatorName Imai, Takao
	NRID 1000000174897 1000000174897 CreatorName Yoshioka, Yoshichika
	NRID 1000080836883 1000080836883 researchmap permalink tsumi tsumi CreatorName Sumi, Takuya
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 CreatorName Inohara, Hidenori
	NRID 1000020216063 1000020216063 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 CreatorName Shimada, Shoichi
Subject	Autoimmune inner ear disease
	Hearing loss
	Rheumatoid arthritis
	Type II collagen
	Vertigo
Description	Harada S., Koyama Y., Imai T., et al. A mouse model of autoimmune inner ear disease without endolymphatic hydrops. Biochimica et Biophysica Acta - Molecular Basis of Disease 1870, 167198 (2024); https://doi.org/10.1016/j.bbadis.2024.167198.
Abstract	Autoimmune inner ear disease (AIED) is an organ-specific disease characterized by irreversible, prolonged, and progressive hearing and equilibrium dysfunctions. The primary symptoms of AIED include asymmetric sensorineural hearing loss accompanied by vertigo, aural fullness, and tinnitus. AIED is divided into primary and secondary types. Research has been conducted using animal models of rheumatoid arthritis (RA), a cause of secondary AIED. However, current models are insufficient to accurately analyze vestibular function, and the mechanism underlying the onset of AIED has not yet been fully elucidated. Elucidation of the mechanism of AIED onset is urgently needed to develop effective treatments. In the present study, we analyzed the pathogenesis of vertigo in autoimmune diseases using a mouse model of type II collagen-induced RA. Auditory brain stem response analysis demonstrated that the RA mouse models exhibited hearing loss, which is the primary symptom of AIED. In addition, our vestibulo-oculomotor reflex analysis, which is an excellent vestibular function test, accurately captured vertigo symptoms in the RA mouse models. Moreover, our results revealed that the cause of hearing loss and vestibular dysfunction was not endolymphatic hydrops, but rather structural destruction of the organ of Corti and the lateral semicircular canal ampulla due to an autoimmune reaction against type II collagen. Overall, we were able to establish a mouse model of AIED without endolymphatic hydrops. Our findings will help elucidate the mechanisms of hearing loss and vertigo associated with AIED and facilitate the development of new therapeutic methods.
Publisher	Elsevier B.V.
Source Title	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume (Issue)	1870(5)
Page	167198
Date of Issued	2024-06-01
Language	English
Handle URL	https://hdl.handle.net/11094/97163
PISSN	09254439
eISSN	1879260X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bbadis.2024.167198
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Biochimica et Biophysica Acta - Molecular Basis of Disease. 2024, 1870(5), p. 167198
DC.title	A mouse model of autoimmune inner ear disease without endolymphatic hydrops
DC.creator	Harada, Shotaro
	Koyama, Yoshihisa
	Imai, Takao
	Yoshioka, Yoshichika
	Sumi, Takuya
	Inohara, Hidenori
	Shimada, Shoichi
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-01
DC.identifier	https://doi.org/10.1016/j.bbadis.2024.167198
DC.subject	Autoimmune inner ear disease
	Hearing loss
	Rheumatoid arthritis
	Type II collagen
	Vertigo
DC.description	Harada S., Koyama Y., Imai T., et al. A mouse model of autoimmune inner ear disease without endolymphatic hydrops. Biochimica et Biophysica Acta - Molecular Basis of Disease 1870, 167198 (2024); https://doi.org/10.1016/j.bbadis.2024.167198.
DCTERMS.abstract	Autoimmune inner ear disease (AIED) is an organ-specific disease characterized by irreversible, prolonged, and progressive hearing and equilibrium dysfunctions. The primary symptoms of AIED include asymmetric sensorineural hearing loss accompanied by vertigo, aural fullness, and tinnitus. AIED is divided into primary and secondary types. Research has been conducted using animal models of rheumatoid arthritis (RA), a cause of secondary AIED. However, current models are insufficient to accurately analyze vestibular function, and the mechanism underlying the onset of AIED has not yet been fully elucidated. Elucidation of the mechanism of AIED onset is urgently needed to develop effective treatments. In the present study, we analyzed the pathogenesis of vertigo in autoimmune diseases using a mouse model of type II collagen-induced RA. Auditory brain stem response analysis demonstrated that the RA mouse models exhibited hearing loss, which is the primary symptom of AIED. In addition, our vestibulo-oculomotor reflex analysis, which is an excellent vestibular function test, accurately captured vertigo symptoms in the RA mouse models. Moreover, our results revealed that the cause of hearing loss and vestibular dysfunction was not endolymphatic hydrops, but rather structural destruction of the organ of Corti and the lateral semicircular canal ampulla due to an autoimmune reaction against type II collagen. Overall, we were able to establish a mouse model of AIED without endolymphatic hydrops. Our findings will help elucidate the mechanisms of hearing loss and vertigo associated with AIED and facilitate the development of new therapeutic methods.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	97163
citation_title	A mouse model of autoimmune inner ear disease without endolymphatic hydrops
citation_author	Harada, Shotaro
	Koyama, Yoshihisa
	Imai, Takao
	Yoshioka, Yoshichika
	Sumi, Takuya
	Inohara, Hidenori
	Shimada, Shoichi
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-06-01
citation_journal_title	Biochimica et Biophysica Acta - Molecular Basis of Disease
citation_volume	1870
citation_issue	5
citation_firstpage	167198
citation_doi	https://doi.org/10.1016/j.bbadis.2024.167198
citation_public_url	https://hdl.handle.net/11094/97163

A mouse model of autoimmune inner ear disease without endolymphatic hydrops

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