Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model

Togawa, Shogo; Usui, Noriyoshi; Doi, Miyuki; Kobayashi, Yuki; Koyama, Yoshihisa; Nakamura, Yukiko; Shinoda, Koh; Kobayashi, Hikaru; Shimada, Shoichi

doi:https://doi.org/10.1016/j.bbr.2024.115040

Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model

Togawa, Shogo; Usui, Noriyoshi; Doi, Miyuki et al.

Behavioural Brain Research, 2024, 468, 115040

Number of Access:1,144（2025-08-16 06:36 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97166

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Title	Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model
Creator	CreatorName Togawa, Shogo
	NRID 1000000784076 1000000784076 ORCID 0000-0001-8079-8013 0000-0001-8079-8013 researchmap permalink noriyoshiusui noriyoshiusui Scopus Author ID 56404181300 56404181300 CreatorName Usui, Noriyoshi
	researchmap permalink doim26 doim26 CreatorName Doi, Miyuki
	CreatorName Kobayashi, Yuki
	NRID 1000040397667 1000040397667 researchmap permalink koyamayoshihisa koyamayoshihisa Scopus Author ID 49761644100 49761644100 CreatorName Koyama, Yoshihisa
	NRID 1000090548083 1000090548083 researchmap permalink 159515951 159515951 CreatorName Nakamura, Yukiko
	NRID 1000040192108 1000040192108 CreatorName Shinoda, Koh
	NRID 1000090195800 1000090195800 researchmap permalink H.K.silicon H.K.silicon CreatorName Kobayashi, Hikaru
	NRID 1000020216063 1000020216063 researchmap permalink 556shimada 556shimada Scopus Author ID 35452177800 35452177800 ORCID 0000-0001-5369-1069 0000-0001-5369-1069 CreatorName Shimada, Shoichi
Subject	6-hydroxydopamine
	Dopaminergic neuron
	Hyperactivity
	Neuroprotection
	Neurotoxin
	Si-based agent
Description	Togawa S., Usui N., Doi M., et al. Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model. Behavioural Brain Research 468, 115040 (2024); https://doi.org/10.1016/j.bbr.2024.115040.
Abstract	Neurotoxins have been extensively investigated, particularly in the field of neuroscience. They induce toxic damage, oxidative stress, and inflammation on neurons, triggering neuronal dysfunction and neurodegenerative diseases. Here we demonstrate the neuroprotective effect of a silicon (Si)-based hydrogen-producing agent (Si-based agent) in a juvenile neurotoxic mouse model induced by 6-hydroxydopamine (6-OHDA). The Si-based agent produces hydrogen in bowels and functions as an antioxidant and anti-inflammatory agent. However, the effects of the Si-based agent on neural degeneration in areas other than the lesion and behavioral alterations caused by it are largely unknown. Moreover, the neuroprotective effects of Si-based agent in the context of lactation and use during infancy have not been explored in prior studies. In this study, we show the neuroprotective effect of the Si-based agent on 6-OHDA during lactation period and infancy using the mouse model. The Si-based agent safeguards against the degradation and neuronal cell death of dopaminergic neurons and loss of dopaminergic fibers in the striatum (STR) and ventral tegmental area (VTA) caused by 6-OHDA. Furthermore, the Si-based agent exhibits a neuroprotective effect on the length of axon initial segment (AIS) in the layer 2/3 (L2/3) neurons of the medial prefrontal cortex (mPFC). As a result, the Si-based agent mitigates hyperactive behavior in a juvenile neurotoxic mouse model induced by 6-OHDA. These results suggest that the Si-based agent serves as an effective neuroprotectant and antioxidant against neurotoxic effects in the brain, offering the possibility of the Si-based agent as a neuroprotectant for nervous system diseases.
Publisher	Elsevier B.V.
Source Title	Behavioural Brain Research
Volume (Issue)	468
Page	115040
Date of Issued	2024-06-25
Language	English
Handle URL	https://hdl.handle.net/11094/97166
PISSN	01664328
eISSN	18727549
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.bbr.2024.115040
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Behavioural Brain Research. 2024, 468, p. 115040
DC.title	Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model
DC.creator	Togawa, Shogo
	Usui, Noriyoshi
	Doi, Miyuki
	Kobayashi, Yuki
	Koyama, Yoshihisa
	Nakamura, Yukiko
	Shinoda, Koh
	Kobayashi, Hikaru
	Shimada, Shoichi
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-06-25
DC.identifier	https://doi.org/10.1016/j.bbr.2024.115040
DC.subject	6-hydroxydopamine
	Dopaminergic neuron
	Hyperactivity
	Neuroprotection
	Neurotoxin
	Si-based agent
DC.description	Togawa S., Usui N., Doi M., et al. Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model. Behavioural Brain Research 468, 115040 (2024); https://doi.org/10.1016/j.bbr.2024.115040.
DCTERMS.abstract	Neurotoxins have been extensively investigated, particularly in the field of neuroscience. They induce toxic damage, oxidative stress, and inflammation on neurons, triggering neuronal dysfunction and neurodegenerative diseases. Here we demonstrate the neuroprotective effect of a silicon (Si)-based hydrogen-producing agent (Si-based agent) in a juvenile neurotoxic mouse model induced by 6-hydroxydopamine (6-OHDA). The Si-based agent produces hydrogen in bowels and functions as an antioxidant and anti-inflammatory agent. However, the effects of the Si-based agent on neural degeneration in areas other than the lesion and behavioral alterations caused by it are largely unknown. Moreover, the neuroprotective effects of Si-based agent in the context of lactation and use during infancy have not been explored in prior studies. In this study, we show the neuroprotective effect of the Si-based agent on 6-OHDA during lactation period and infancy using the mouse model. The Si-based agent safeguards against the degradation and neuronal cell death of dopaminergic neurons and loss of dopaminergic fibers in the striatum (STR) and ventral tegmental area (VTA) caused by 6-OHDA. Furthermore, the Si-based agent exhibits a neuroprotective effect on the length of axon initial segment (AIS) in the layer 2/3 (L2/3) neurons of the medial prefrontal cortex (mPFC). As a result, the Si-based agent mitigates hyperactive behavior in a juvenile neurotoxic mouse model induced by 6-OHDA. These results suggest that the Si-based agent serves as an effective neuroprotectant and antioxidant against neurotoxic effects in the brain, offering the possibility of the Si-based agent as a neuroprotectant for nervous system diseases.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	97166
citation_title	Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model
citation_author	Togawa, Shogo
	Usui, Noriyoshi
	Doi, Miyuki
	Kobayashi, Yuki
	Koyama, Yoshihisa
	Nakamura, Yukiko
	Shinoda, Koh
	Kobayashi, Hikaru
	Shimada, Shoichi
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-06-25
citation_journal_title	Behavioural Brain Research
citation_volume	468
citation_firstpage	115040
citation_doi	https://doi.org/10.1016/j.bbr.2024.115040
citation_public_url	https://hdl.handle.net/11094/97166

Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model

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