Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

Fukuda, Masatoshi; Okanishi, Hiroki; Ino, Daisuke et al.

PLoS ONE, 2024, 19(5), e0303375

Number of Access:2,082（2025-12-03 10:36 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97216

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Title
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model
Creator
NRID
1000060909638 1000060909638
CreatorName
Fukuda, Masatoshi
NRID
1000070792589 1000070792589
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Scopus Author ID
56593651700 56593651700
CreatorName
Okanishi, Hiroki
NRID
1000040721981 1000040721981
ORCID
0000-0002-8112-0746 0000-0002-8112-0746
researchmap permalink
daisukeino daisukeino
CreatorName
Ino, Daisuke
NRID
1000070972165 1000070972165
ORCID
0000-0002-3857-0055 0000-0002-3857-0055
researchmap permalink
drono drono
CreatorName
Ono, Kazuya
CreatorName
Kawamura, Satoru
NRID
1000040964896 1000040964896
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eri_wakai eri_wakai
CreatorName
Wakai, Eri
CreatorName
Miyoshi, Tsuyoshi
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4501 4501
Scopus Author ID
7406982585 7406982585
CreatorName
Sato, Takashi
NRID
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osaka-ent osaka-ent
Scopus Author ID
54416193500 54416193500
CreatorName
Ohta, Yumi
NRID
1000090360552 1000090360552
CreatorName
Saito, Takashi
NRID
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CreatorName
Saido, Takaomi C.
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read0046473 read0046473
Scopus Author ID
7004501837 7004501837
CreatorName
Inohara, Hidenori
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read0063550 read0063550
Scopus Author ID
55575124400 55575124400
CreatorName
Kanai, Yoshikatsu
NRID
1000070314317 1000070314317
researchmap permalink
hiroshi_hibino hiroshi_hibino
Scopus Author ID
7007020846 7007020846
CreatorName
Hibino, Hiroshi
Description
Fukuda M., Okanishi H., Ino D., et al. (2024) Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model. PLoS ONE 19, e0303375. https://doi.org/10.1371/journal.pone.0303375.
Abstract
Hearing loss is a pivotal risk factor for dementia. It has recently emerged that a disruption in the intercommunication between the cochlea and brain is a key process in the initiation and progression of this disease. However, whether the cochlear properties can be influenced by pathological signals associated with dementia remains unclear. In this study, using a mouse model of Alzheimer’s disease (AD), we investigated the impacts of the AD-like amyloid β (Aβ) pathology in the brain on the cochlea. Despite little detectable change in the age-related shift of the hearing threshold, we observed quantitative and qualitative alterations in the protein profile in perilymph, an extracellular fluid that fills the path of sound waves in the cochlea. Our findings highlight the potential contribution of Aβ pathology in the brain to the disturbance of cochlear homeostasis.
Publisher
Public Library of Science
Source Title
PLoS ONE
Volume (Issue)
19(5)
Page
e0303375
Date of Issued
2024-05-10
Language
English
Handle URL
https://hdl.handle.net/11094/97216
eISSN
19326203
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1371/journal.pone.0303375
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article