Characterization of the unique oral microbiome of children harboring Helicobacter pylori in the oral cavity

Ogaya, Yuko; Kadota, Tamami; Hamada, Masakazu et al.

Journal of Oral Microbiology, 2024, 16(1), 2339158

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Identifier to cite or link to this item: https://hdl.handle.net/11094/97219

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Title
Characterization of the unique oral microbiome of children harboring Helicobacter pylori in the oral cavity
Creator
NRID
1000040803078 1000040803078
researchmap permalink
y_ogaya y_ogaya
Scopus Author ID
56460237100 56460237100
CreatorName
Ogaya, Yuko
NRID
1000010908643 1000010908643
researchmap permalink
kadota-tamami kadota-tamami
CreatorName
Kadota, Tamami
NRID
1000080506361 1000080506361
researchmap permalink
6361 6361
Scopus Author ID
36616148000 36616148000
CreatorName
Hamada, Masakazu
NRID
1000090437385 1000090437385
CreatorName
Nomura, Ryota
NRID
1000000379083 1000000379083
researchmap permalink
read0202427 read0202427
Scopus Author ID
7402011667 7402011667
CreatorName
Nakano, Kazuhiko
Subject
Helicobacter pylori
metagenomic analysis
oral cavity
oral microbiome
saliva
Description
Ogaya Y., Kadota T., Hamada M., et al. Characterization of the unique oral microbiome of children harboring Helicobacter pylori in the oral cavity. Journal of Oral Microbiology 16, 2339158 (2024); https://doi.org/10.1080/20002297.2024.2339158.
Abstract
Objective: Helicobacter pylori infection is acquired in childhood via the oral cavity, although its relationship with the characteristics of the oral microbiome has not been elucidated. In this study, we performed comprehensive analysis of the oral microbiome in children and adults with or without H. pylori in the oral cavity. Methods: Bacterial DNA was extracted from 41 adult and 21 child saliva specimens, and H. pylori was detected using PCR. 16S rRNA gene amplification was performed for next-generation sequencing. Bioinformatic analyses were conducted using Quantitative Insights into Microbial Ecology 2 (QIIME 2). Results: Faith’s phylogenetic diversity analysis showed a significant difference between H. pylori-negative adult and child specimens in terms of α-diversity (p < 0.05), while no significant difference was observed between H. pylori-positive adult and child specimens. There was also a significant difference in β-diversity between H. pylori-positive and negative child specimens (p < 0.05). Taxonomic analysis at the genus level revealed that Porphyromonas was the only bacterium that was significantly more abundant in both H. pylori-positive adults and children than in corresponding negative specimens (p < 0.01 and p < 0.05, respectively). Conclusion: These results suggest unique oral microbiome characteristics in children with H. pylori infection in the oral cavity.
Publisher
Taylor and Francis Ltd.
Source Title
Journal of Oral Microbiology
Volume (Issue)
16(1)
Page
2339158
Date of Issued
2024-04-11
Language
English
Handle URL
https://hdl.handle.net/11094/97219
eISSN
20002297
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1080/20002297.2024.2339158
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article