Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

Mori, Nobuhiko; Hosomi, Koichi; Nishi, Asaya; Miyake, Akimitsu; Yamada, Tomomi; Matsugi, Akiyoshi; Jono, Yasutomo; Lim, Chanseok; Khoo, Hui Ming; Tani, Naoki; Oshino, Satoru; Saitoh, Youichi; Kishima, Haruhiko

doi:https://doi.org/10.1038/s41598-024-62018-x

Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

Mori, Nobuhiko; Hosomi, Koichi; Nishi, Asaya et al.

Scientific Reports, 2024, 14, 11811

Number of Access:1,565（2025-07-18 18:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97225

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Title	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
Creator	NRID 1000020833924 1000020833924 ORCID 0000-0001-6537-6322 0000-0001-6537-6322 researchmap permalink Mori_Nobuhiko Mori_Nobuhiko CreatorName Mori, Nobuhiko
	NRID 1000070533800 1000070533800 researchmap permalink HosomiKoichi HosomiKoichi Scopus Author ID 23967898900 23967898900 ORCID 0000-0001-7731-3302 0000-0001-7731-3302 CreatorName Hosomi, Koichi
	CreatorName Nishi, Asaya
	NRID 1000070872290 1000070872290 CreatorName Miyake, Akimitsu
	NRID 1000060363371 1000060363371 researchmap permalink ymd ymd Scopus Author ID 35254679600 35254679600 CreatorName Yamada, Tomomi
	NRID 1000020624026 1000020624026 CreatorName Matsugi, Akiyoshi
	CreatorName Jono, Yasutomo
	CreatorName Lim, Chanseok
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 CreatorName Khoo, Hui Ming
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 CreatorName Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	NRID 1000020252661 1000020252661 researchmap permalink read0076638 read0076638 CreatorName Saitoh, Youichi
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
Description	Mori N., Hosomi K., Nishi A., et al. Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial. Scientific Reports 14, 11811 (2024); https://doi.org/10.1038/s41598-024-62018-x.
Abstract	This study aimed to evaluate the efficacy and safety of navigation-guided repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in patients with neuropathic pain in the upper limb. This randomized, blinded, sham-controlled, parallel trial included a rTMS protocol (10-Hz, 2000 pulses/session) consisting of five daily sessions, followed by one session per week for the next seven weeks. Pain intensity, as well as pain-related disability, quality of life, and psychological status, were assessed. For the primary outcome, pain intensity was measured daily using a numerical rating scale as a pain diary. Thirty patients were randomly assigned to the active rTMS or sham-stimulation groups. In the primary outcome, the decrease (least square [LS] mean ± standard error) in the weekly average of a pain diary at week 9 compared to the baseline was 0.84 ± 0.31 in the active rTMS group and 0.58 ± 0.29 in the sham group (LS mean difference, 0.26; 95% confidence interval, − 0.60 to 1.13). There was no significant effect on the interaction between the treatment group and time point. Pain-related disability score improved, but other assessments showed no differences. No serious adverse events were observed. This study did not show significant pain relief; however, active rTMS tended to provide better results than sham. rTMS has the potential to improve pain-related disability in addition to pain relief.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14
Page	11811
Date of Issued	2024-05-23
Language	English
Handle URL	https://hdl.handle.net/11094/97225
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-62018-x
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14, p. 11811
DC.title	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
DC.creator	Mori, Nobuhiko
	Hosomi, Koichi
	Nishi, Asaya
	Miyake, Akimitsu
	Yamada, Tomomi
	Matsugi, Akiyoshi
	Jono, Yasutomo
	Lim, Chanseok
	Khoo, Hui Ming
	Tani, Naoki
	Oshino, Satoru
	Saitoh, Youichi
	Kishima, Haruhiko
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-23
DC.identifier	https://doi.org/10.1038/s41598-024-62018-x
DC.description	Mori N., Hosomi K., Nishi A., et al. Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial. Scientific Reports 14, 11811 (2024); https://doi.org/10.1038/s41598-024-62018-x.
DCTERMS.abstract	This study aimed to evaluate the efficacy and safety of navigation-guided repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in patients with neuropathic pain in the upper limb. This randomized, blinded, sham-controlled, parallel trial included a rTMS protocol (10-Hz, 2000 pulses/session) consisting of five daily sessions, followed by one session per week for the next seven weeks. Pain intensity, as well as pain-related disability, quality of life, and psychological status, were assessed. For the primary outcome, pain intensity was measured daily using a numerical rating scale as a pain diary. Thirty patients were randomly assigned to the active rTMS or sham-stimulation groups. In the primary outcome, the decrease (least square [LS] mean ± standard error) in the weekly average of a pain diary at week 9 compared to the baseline was 0.84 ± 0.31 in the active rTMS group and 0.58 ± 0.29 in the sham group (LS mean difference, 0.26; 95% confidence interval, − 0.60 to 1.13). There was no significant effect on the interaction between the treatment group and time point. Pain-related disability score improved, but other assessments showed no differences. No serious adverse events were observed. This study did not show significant pain relief; however, active rTMS tended to provide better results than sham. rTMS has the potential to improve pain-related disability in addition to pain relief.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97225
citation_title	Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial
citation_author	Mori, Nobuhiko
	Hosomi, Koichi
	Nishi, Asaya
	Miyake, Akimitsu
	Yamada, Tomomi
	Matsugi, Akiyoshi
	Jono, Yasutomo
	Lim, Chanseok
	Khoo, Hui Ming
	Tani, Naoki
	Oshino, Satoru
	Saitoh, Youichi
	Kishima, Haruhiko
citation_publisher	Nature Research
citation_language	English
citation_date	2024-05-23
citation_journal_title	Scientific Reports
citation_volume	14
citation_firstpage	11811
citation_doi	https://doi.org/10.1038/s41598-024-62018-x
citation_public_url	https://hdl.handle.net/11094/97225

Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial

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