Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams

Yagi, Masashi; Shimizu, Shinichi; Hamatani, Noriaki; Miyoshi, Takuto; Nomura, Takuya; Toyoda, Takashi; Nakatani, Mahoro; Tsubouchi, Toshiro; Shimizu, Masaki; Kuwana, Yoshiaki; Umezawa, Masumi; Takashina, Masaaki; Nishio, Teiji; Koizumi, Masahiko; Ogawa, Kazuhiko; Kanai, Tatsuaki

doi:https://doi.org/10.1038/s41598-024-62148-2

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams

Yagi, Masashi; Shimizu, Shinichi; Hamatani, Noriaki et al.

Scientific Reports, 2024, 14, 11574

Number of Access:153（2025-05-21 12:30 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97226

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Title	Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams
Creator	NRID 1000040737491 1000040737491 ORCID 0000-0002-2827-5407 0000-0002-2827-5407 researchmap permalink yagi-masashi yagi-masashi Scopus Author ID 55643361900 55643361900 CreatorName Yagi, Masashi
	NRID 1000050463724 1000050463724 researchmap permalink shing shing Scopus Author ID 7403432592 7403432592 CreatorName Shimizu, Shinichi
	CreatorName Hamatani, Noriaki
	CreatorName Miyoshi, Takuto
	CreatorName Nomura, Takuya
	CreatorName Toyoda, Takashi
	CreatorName Nakatani, Mahoro
	CreatorName Tsubouchi, Toshiro
	CreatorName Shimizu, Masaki
	CreatorName Kuwana, Yoshiaki
	CreatorName Umezawa, Masumi
	NRID 1000010392010 1000010392010 researchmap permalink read0118020 read0118020 CreatorName Takashina, Masaaki
	NRID 1000040415526 1000040415526 researchmap permalink 551214 551214 Scopus Author ID 55822203900 55822203900 CreatorName Nishio, Teiji
	NRID 1000090186594 1000090186594 ORCID 0000-0003-3438-9811 0000-0003-3438-9811 researchmap permalink read0006874 read0006874 Scopus Author ID 7201931513 7201931513 CreatorName Koizumi, Masahiko
	NRID 1000040253984 1000040253984 researchmap permalink read0097694 read0097694 Scopus Author ID 7404212602 7404212602 CreatorName Ogawa, Kazuhiko
	NRID 1000080161149 1000080161149 researchmap permalink read0003611 read0003611 CreatorName Kanai, Tatsuaki
Description	Yagi M., Shimizu S., Hamatani N., et al. Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams. Scientific Reports 14, 11574 (2024); https://doi.org/10.1038/s41598-024-62148-2.
Abstract	The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging. We developed and characterized a dedicated dose monitor for uHDR-scanned carbon-ion beams. Furthermore, a simple measurable dose rate (dose rate per spot (DRspot)) was suggested by using the developed dose monitor and experimentally validating quantities relevant to the uHDR scanned carbon-ion beam. A large plane-parallel ionization chamber (IC) with a smaller electrode spacing was used to reduce uHDR recombination effects, and a dedicated operational amplifier was manufactured for the uHDR-scanned carbon-ion beam. The dose linearity of the IC was within ± 1% in the range of 1.8–12.3 Gy. The spatial inhomogeneity of the dose response of the IC was ± 0.38% inside the ± 40-mm detector area, and a systematic deviation of approximately 2% was measured at the edge of the detector. uHDR irradiation with beam scanning was tested and verified for different doses at the corresponding dose rates (in terms of both the average dose rate and DRspot). We confirmed that the dose monitor can highlight the characteristics (i.e., dose, dose rate, and dose profile) of uHDR-scanned carbon-ion beams at several dose levels in the monochromatic beam mode.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14
Page	11574
Date of Issued	2024-05-21
Language	English
Handle URL	https://hdl.handle.net/11094/97226
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-62148-2
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14, p. 11574
DC.title	Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams
DC.creator	Yagi, Masashi
	Shimizu, Shinichi
	Hamatani, Noriaki
	Miyoshi, Takuto
	Nomura, Takuya
	Toyoda, Takashi
	Nakatani, Mahoro
	Tsubouchi, Toshiro
	Shimizu, Masaki
	Kuwana, Yoshiaki
	Umezawa, Masumi
	Takashina, Masaaki
	Nishio, Teiji
	Koizumi, Masahiko
	Ogawa, Kazuhiko
	Kanai, Tatsuaki
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-05-21
DC.identifier	https://doi.org/10.1038/s41598-024-62148-2
DC.description	Yagi M., Shimizu S., Hamatani N., et al. Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams. Scientific Reports 14, 11574 (2024); https://doi.org/10.1038/s41598-024-62148-2.
DCTERMS.abstract	The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging. We developed and characterized a dedicated dose monitor for uHDR-scanned carbon-ion beams. Furthermore, a simple measurable dose rate (dose rate per spot (DRspot)) was suggested by using the developed dose monitor and experimentally validating quantities relevant to the uHDR scanned carbon-ion beam. A large plane-parallel ionization chamber (IC) with a smaller electrode spacing was used to reduce uHDR recombination effects, and a dedicated operational amplifier was manufactured for the uHDR-scanned carbon-ion beam. The dose linearity of the IC was within ± 1% in the range of 1.8–12.3 Gy. The spatial inhomogeneity of the dose response of the IC was ± 0.38% inside the ± 40-mm detector area, and a systematic deviation of approximately 2% was measured at the edge of the detector. uHDR irradiation with beam scanning was tested and verified for different doses at the corresponding dose rates (in terms of both the average dose rate and DRspot). We confirmed that the dose monitor can highlight the characteristics (i.e., dose, dose rate, and dose profile) of uHDR-scanned carbon-ion beams at several dose levels in the monochromatic beam mode.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97226
citation_title	Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams
citation_author	Yagi, Masashi
	Shimizu, Shinichi
	Hamatani, Noriaki
	Miyoshi, Takuto
	Nomura, Takuya
	Toyoda, Takashi
	Nakatani, Mahoro
	Tsubouchi, Toshiro
	Shimizu, Masaki
	Kuwana, Yoshiaki
	Umezawa, Masumi
	Takashina, Masaaki
	Nishio, Teiji
	Koizumi, Masahiko
	Ogawa, Kazuhiko
	Kanai, Tatsuaki
citation_publisher	Nature Research
citation_language	English
citation_date	2024-05-21
citation_journal_title	Scientific Reports
citation_volume	14
citation_firstpage	11574
citation_doi	https://doi.org/10.1038/s41598-024-62148-2
citation_public_url	https://hdl.handle.net/11094/97226

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams

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