Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly

Mitsui, Yuto; Mukai, Kosuke; Otsuki, Michio et al.

Pituitary, 2024, 27(5), 527-536

Number of Access:1,150（2025-07-18 09:52 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97604

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Title
Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly
Creator
CreatorName
Mitsui, Yuto
NRID
1000020815352 1000020815352
researchmap permalink
mukai mukai
Scopus Author ID
55045414800 55045414800
CreatorName
Mukai, Kosuke
NRID
1000030456751 1000030456751
researchmap permalink
michio_otsuki michio_otsuki
Scopus Author ID
7202018048 7202018048
ORCID
0000-0002-6533-7144 0000-0002-6533-7144
CreatorName
Otsuki, Michio
NRID
1000040403050 1000040403050
ORCID
0000-0002-4248-2322 0000-0002-4248-2322
researchmap permalink
handai_ns_oshino handai_ns_oshino
Scopus Author ID
6602717325 6602717325
CreatorName
Oshino, Satoru
NRID
1000020252661 1000020252661
researchmap permalink
read0076638 read0076638
CreatorName
Saitoh, Youichi
ORCID
0009-0006-7636-5833 0009-0006-7636-5833
CreatorName
Kohara, Masaharu
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiichi
NRID
1000000437328 1000000437328
ORCID
0000-0002-6289-3778 0000-0002-6289-3778
researchmap permalink
AtsuF AtsuF
Scopus Author ID
7003835710 7003835710
CreatorName
Fukuhara, Atsunori
NRID
1000060346145 1000060346145
researchmap permalink
shimomura_i shimomura_i
Scopus Author ID
7006715546 7006715546
ORCID
0000-0002-0851-9603 0000-0002-0851-9603
CreatorName
Shimomura, Iichiro
Subject
Acromegaly
Gonadotropin
LHRH
Somatostatin
Steroidogenic factor 1
Description
The version of record of this article, first published in Pituitary, is available online at Publisher’s website: https://doi.org/10.1007/s11102-024-01410-2.
Abstract
Purpose: We previously showed the clinical characteristics of acromegaly with a paradoxical growth hormone (GH) response to oral glucose or thyrotropin-releasing hormone. However, the clinical characteristics of acromegaly with an increased GH response to luteinizing hormone-releasing hormone (LHRH responders) remain unclear. The aim of the present study was to evaluate the clinical characteristics, especially gonadotroph-related characteristics of LHRH responders in acromegaly. Methods: The clinical characteristics of 33 LHRH responders and 81 LHRH nonresponders were compared. Results: No differences in age, sex or basal serum levels of GH, insulin-like growth factor-1 (IGF-1), and gonadotropin were observed between the two groups. Steroidogenic factor 1 (SF-1), gonadotropin-releasing hormone receptor (GnRHR), and LH expression was more frequently observed in LHRH responders (P < 0.05). In addition, a greater increased rate of GH after LHRH loading, and the proportion of GnRHR and gonadotropin expression was observed in pituitary tumor with SF-1 expression than that without the expression (P < 0.01). LHRH responders showed a greater GH decrease in the octreotide test and a greater IGF-1 decrease after first-generation somatostatin ligand than LHRH nonresponders (P < 0.05). Furthermore, the proportion of hypointense pituitary tumors on T2-weighted magnetic resonance imaging and tumors with densely granulated type was higher in LHRH responders than in LHRH nonresponders, respectively (P < 0.05). No difference between the two groups was observed in either somatostatin receptor 2 or 5 expression. Conclusions: The increased GH response to LHRH is associated with the gonadotroph-related characteristics. This response may reflect the biological characteristics of somatotroph tumors.
Publisher
Springer
Source Title
Pituitary
Volume (Issue)
27(5)
Page
527-536
Date of Issued
2024-06-19
Language
English
Handle URL
https://hdl.handle.net/11094/97604
PISSN
1386341X
eISSN
15737403
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1007/s11102-024-01410-2
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article