TiO₂ nanotubes with customized diameters for local drug delivery systems

Miyabe, Sayaka; Fujinaga, Yushi; Tsuchiya, Hiroaki et al.

Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2024, 112(7), e35445

Number of Access:736（2025-09-30 08:00 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97617

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Title
TiO₂ nanotubes with customized diameters for local drug delivery systems
Creator
NRID
1000050584132 1000050584132
researchmap permalink
read0151100 read0151100
Scopus Author ID
16239274400 16239274400
CreatorName
Miyabe, Sayaka
CreatorName
Fujinaga, Yushi
NRID
1000050432513 1000050432513
ORCID
0000-0001-5619-0139 0000-0001-5619-0139
researchmap permalink
read0076368 read0076368
Scopus Author ID
7202203364 7202203364
CreatorName
Tsuchiya, Hiroaki
NRID
1000070199371 1000070199371
ORCID
0000-0002-7787-4190 0000-0002-7787-4190
researchmap permalink
read0013980 read0013980
Scopus Author ID
57211614674 57211614674
CreatorName
Fujimoto, Shinji
Subject
anodization
local drug delivery system
oxide nanotubes
TiO₂ nanotubes
Description
Miyabe S., Fujinaga Y., Tsuchiya H., et al. TiO₂ nanotubes with customized diameters for local drug delivery systems. Journal of Biomedical Materials Research - Part B Applied Biomaterials 112, e35445 (2024); https://doi.org/10.1002/jbm.b.35445.
Abstract
In this study, we evaluated the drug release behavior of diameter customized TiO₂ nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two-diameter]), and a 20–60 V swept potential (49 nm [full-tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two-diameter) and 49 nm (full-tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two-diameter), 49 nm (full-tapered), and 45 nm samples. The initial burst released drug amounts and release rates from the 50 nm (two-diameter) and 49 nm (full-tapered) samples were significantly suppressed by the smaller tube top. On the other hand, the largest proportion of the slow released drug amount to the total released drug amount was observed for the 50 nm (two-diameter) sample. Thus, 50 nm (two-diameter) achieved suppressed initial burst release and large storage capacity. Therefore, this study has, for the first time, applied TiO₂ nanotube layers with modulated diameters (two-diameter and full-tapered) to the realization of a localized drug delivery system (LDDS) with customized drug release properties.
Publisher
John Wiley and Sons Inc
Source Title
Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume (Issue)
112(7)
Page
e35445
Date of Issued
2024-07-01
Language
English
Handle URL
https://hdl.handle.net/11094/97617
PISSN
15524973
eISSN
15524981
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/jbm.b.35445
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article