Development of functional spermatozoa in mammalian spermiogenesis

Miyata, Haruhiko; Shimada, Keisuke; Kaneda, Yuki et al.

Development, 2024, 151(14)

Number of Access:485（2025-08-22 01:03 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97736

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Title
Development of functional spermatozoa in mammalian spermiogenesis
Creator
NRID
1000050604732 1000050604732
researchmap permalink
hmiyata hmiyata
Scopus Author ID
37161837000 37161837000
ORCID
0000-0003-4758-5803 0000-0003-4758-5803
CreatorName
Miyata, Haruhiko
NRID
1000060779601 1000060779601
ORCID
0000-0003-3739-7163 0000-0003-3739-7163
researchmap permalink
nununununu nununununu
Scopus Author ID
56479808000 56479808000
CreatorName
Shimada, Keisuke
CreatorName
Kaneda, Yuki
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
CreatorName
Ikawa, Masahito
Subject
Acrosome
Flagellum
Knockout mice
Male fertility
Spermatogenesis
Description
Miyata H., Shimada K., Kaneda Y., et al. Development of functional spermatozoa in mammalian spermiogenesis. Development 151, (2024); https://doi.org/10.1242/dev.202838.
Abstract
Infertility is a global health problem affecting one in six couples, with 50% of cases attributed to male infertility. Spermatozoa are male gametes, specialized cells that can be divided into two parts: the head and the flagellum. The head contains a vesicle called the acrosome that undergoes exocytosis and the flagellum is a motility apparatus that propels the spermatozoa forward and can be divided into two components, axonemes and accessory structures. For spermatozoa to fertilize oocytes, the acrosome and flagellum must be formed correctly. In this Review, we describe comprehensively how functional spermatozoa develop in mammals during spermiogenesis, including the formation of acrosomes, axonemes and accessory structures by focusing on analyses of mouse models.
Publisher
Company of Biologists Ltd
Source Title
Development
Volume (Issue)
151(14)
Date of Issued
2024-07-22
Language
English
Handle URL
https://hdl.handle.net/11094/97736
PISSN
09501991
eISSN
14779129
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1242/dev.202838
Access Rights
open access
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article